Dr. D Boulware, MD MPH

@drboulware.bsky.social

Professor of Medicine at U of MN; Practicing infectious disease doc; budding mycologist; interested in cryptococcal & TB meningitis. Ran some RCTs during COVID, but more excited to return to focus on RCTs on HIV-related meningitis & advanced HIV disease

Dead or alive, Mitch McConnell is on extended medical leave — on your dime. This is the same Mitch McConnell who voted against: paid family and medical leave for everyone else.

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A growing outbreak of the Cyclospora parasite, which causes severe diarrhea, has sickened more than 1,200 people across the U.S. Experts say the true number is much higher. In March 2025, RFK Jr. dissolved the CDC’s Division of Parasitic Diseases and Malaria, which monitored parasitic diseases

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I don’t think people really understand how bad the OMB proposed rule is going to be for state and local govt. We’re talking about putting a full third of state budgets under the explicit control of Russ Vought. (1/2) www.bondbuyer.com/news/cities-...

Cities, states warn of credit impact from proposed federal grant rule

Discretionary termination of grants allowed under the rule would pose a particular risk, issuer advocates said.

bondbuyer.com

NEW: Citing ProPublica’s reporting, two lawmakers have called on the CDC to address a “preventable public health crisis” of parents refusing the vitamin K shot for their newborns — which has led to babies suffering uncontrollable bleeding and even dying.

Lawmakers Call for CDC to Track Vitamin K Shot Refusals, Cite ProPublica Report

Two members of Congress are urging federal officials to monitor vitamin K shot refusals by parents and the potential consequences for their newborns, including severe bleeding or death.

propublica.org

ICE claims that Araujo drove into one of their SUVs with his van and then tried to run over an agent. There were no marks on the van and KHOU11's Jeremy Rogalski found surveillance footage showing ICE chasing Araujo and cutting him off. Renee Good all over again.

"…as of July 2025, the CDC made tracking cyclospora optional, as part of scaling back its Foodborne Diseases Active Surveillance Network. At the time, food safety experts worried that it could make it harder to identify and respond to outbreaks."

Bruno J. Navarro@brunojnavarro.bsky.social · 4w ago

The demand for tests for cyclosporiasis, a pathogen often caused by contaminated fresh produce, is so intense, with so many patients seeking help for diarrhea and crippling abdominal cramps, that many labs can’t keep up.

Running a lab is like running a small business. When you run out of money, you close. Right now we are favoring incumbents and squeezing out the most vulnerable. Life saving research is abruptly shutting down and early career scientists are paying the price!

Trauma Code on WBAI@traumacode.bsky.social · 4w ago

Thanks again to @michaeldgreen.phd for telling us how politicization of NIH funding has derailed early career researchers. Catch us every Monday 2pm on the #TraumaCode on WBAI 99.5 FM NYC podcasts.apple.com/us/podcast/t...

Trial of metformin in 2983 adults showed 2.6% had symptoms at day 180; metformin cut clinician-diagnosed long COVID by 0.7% pts (RR 0.495); no deaths. 💊🦠

Metformin on the Presence of COVID-19 Symptoms 6 Months after Infection: The ACTIV-6 Randomized Clinical Trial

We conducted a quadruple-blinded, randomized, placebo-controlled trial of metformin for treating acute SARS-CoV-2 infection to prevent long COVID symptoms in low-risk adults.MethodsThe ACTIV-6 platform evaluated repurposed medications for mild to moderate COVID-19. Between September 19, 2023 and May 1, 2024, 2983 outpatient adults ≥30 years with confirmed SARS-CoV-2 infection and ≥2 COVID-19 symptoms were included within 7 days of symptom onset from 90 sites. Participants were randomized to metformin or placebo for 14 days. Post-acute sequelae of SARS-CoV-2 or death (PASCD) was ascertained by asking whether participants had symptoms they attributed to COVID-19 on day 180. Secondary outcomes included clinician-diagnosed long COVID.ResultsThe median age was 47 years (interquartile range 38–57); 63% were female; 47% Hispanic/Latino; 83% reported ≥1 prior COVID-19 infections or ≥2 SARS-CoV-2 vaccines. There were no deaths. Overall, 96 (3.2%) reported COVID-19 symptoms on day 90, 101 (3.4%) on day 120, and 79 (2.6%) on day 180. The adjusted risk of symptoms on day 180 was 0.8 percentage points lower with metformin (95% credible interval [CrI] -2.2 to 0.6) with a posterior probability of efficacy [PPE] for preventing symptoms of 0.83, risk ratio 0.79 (95% CrI 0.474 to 1.230). Compared with placebo, the risk of clinician-diagnosed long COVID was 0.7 percentage points lower with metformin (95% CrI -1.5 to 0.1); PPE 0.96; risk ratio 0.495 (95% CrI 0.155 to 0.995).Conclusions and RelevanceIn low-risk adults, most with prior immunity, metformin did not exceed the efficacy threshold of 0.975 for PASC. Metformin reduced the risk of clinician-diagnosed long COVID.

academic.oup.com

On IDSA’s & HIVMA’s Science Speaks blog: Sidhya Choudhary, MD, explores how fungal infections can often be mistaken for tuberculosis in TB-endemic settings, which can delay appropriate treatment, and what can be done to catch these infections sooner. bit.ly/3RS0hsk

Are fungal infections being missed under the shadow of TB in endemic settings?

Sidhya Choudhary, MD, explores how fungal infections can often be mistaken for tuberculosis in TB-endemic settings, which can delay appropriate treatment.

bit.ly

All US citizens returning from Uganda, DRC, or South Sudan must arrive through Dulles (IAD) airport starting today. CDC host quarantine officers at major intl airports, and on prior occasions (W Africa 2015 #ebola outbreak), one could enter through handful of places, not just 1 place.