Congratulations to @childrensphila.bsky.social Allergy/Immunology and @upenn.edu researcher Sarah Henrickson and team on their new publication! JCI - Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype www.jci.org/articles/vie...

New data out of Australia provides more evidence that early allergen introduction works to reduce new-onset food allergy! www.cnn.com/2026/06/08/h...

Childhood egg allergies fall as early introduction becomes more common, new study finds | CNN

Parents used to be advised to keep allergenic foods like eggs away from babies, especially if allergies ran in the family. But based on recent and evolving evidence, the advice is now almost the oppos...

cnn.com

BIG congratulations to Hill Lab Manager and Head of Basic Science Research Nicole who just won the CHOP Outstanding Research Staff Award for Research Leadership!

Congratulations to Divyansi Pandey, Hill Lab @upenn.edu PhD student, for passing her preliminary exam!

Congratulations to all of the @upenn.edu graduates!

New review out now on precision medicine in #EoE. Big thanks to my co-author Caitlin Burk! pubmed.ncbi.nlm.nih.gov/42134747/

Precision medicine in eosinophilic esophagitis - PubMed

Eosinophilic esophagitis (EoE) is a common, chronic, immune-mediated disease of the esophagus, affecting approximately 1 in 700 individuals in the United States. Despite rising prevalence, clinical ma...

pubmed.ncbi.nlm.nih.gov

I’m grateful to share that I’ve been promoted to Associate Professor of Pediatrics at @upenn.edu, with tenure. This milestone reflects the support of outstanding trainees, collaborators, mentors, patients, and colleagues over many years. I’m excited for what comes next for the lab and our research.

Great to speak at the #FoodAllergyFund Annual Summit about the urgent need for expanded research at the intersection of #FoodAllergy and the #Microbiome. Grateful for the thoughtful discussion and inspired by such an engaged community of advocates, families, researchers, and clinicians.

Really nice to see this new MPAACH cohort analysis from Drs. Chang, Biagini, and colleagues. In a prospective early-life AD cohort, they show enrichment of EoE—particularly with food sensitization/allergy—and trajectories placing EoE squarely in the atopic march. www.jacionline.org/article/S009...

Longitudinal enrichment of eosinophilic esophagitis in children with AD: The MPAACH cohort

The atopic march refers to the natural history of allergic disease manifestations as they develop in childhood.1 Classically, the march begins with atopic dermatitis (AD), followed sequentially by foo...

jacionline.org

Very important paper below from CHOP A/I division researchers Stan Gabryszewski and Jonathan Spergel on the association between Dupilumab use and autoimmune conditions. An important consideration that warrants more investigation. pubmed.ncbi.nlm.nih.gov/41895450/

Incidence of Autoimmune Diseases in Children with Atopy Treated with Dupilumab - PubMed

We detected a modest association between dupilumab and cutaneous autoimmune disease diagnosis in atopic children. These findings help address knowledge gaps about clinical outcomes in atopic children treated with this biologic.

pubmed.ncbi.nlm.nih.gov

Congratulations to Hill Lab member Sam McCright who was recently recognized with the International Klosterfrau Group Award for his research on the effects of dietary fats on childhood asthma. Congratulations Sam! www.klosterfrau.com/en/company/c...

Had a great conversation with Pittsburgh Mayor Corey O’Connor on pediatric health, education, and environmental initiatives—and how partnerships between cities, hospitals, and universities can translate science into healthier futures for children and communities. @coreyoconnorpa.bsky.social #PGH

Honored to be joining the @aaaaiorg.bsky.social Foundation Council as Vice Chair for Research and Long-Range Planning. Looking forward to partnering with Elizabeth Phillips and the Council to help guide the Foundation’s research vision for the coming decade. #AAAAI

Honored and excited to join the Editorial Board at @allergy-eaaci.bsky.social! The flagship journal of the European Academy of Allergy and Clinical Immunology. #EAACI #Allergy

Excited to share new work from our lab in @insight.jci.org 🎉 We find that #CD9 is a key regulator of adipose tissue lipid-associated macrophages #LAMs in obesity. Deleting CD9 improves metabolism in obese mice. Credit to first author Julia Chini and team! Read now: insight.jci.org/articles/vie...

Check out this new article on #PPIs in #EoE from CHOP physician-scientist Melanie Ruffner and her lab. pubmed.ncbi.nlm.nih.gov/41760554/

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils - PubMed

Omeprazole diminished the effects of IL-13 in both the epithelial air-liquid interface model and eosinophil-epithelial co-cultures, alleviating barrier dysfunction, chemokine expression, and the upregulation of eosinophil adhesion markers.

pubmed.ncbi.nlm.nih.gov

Check out this new article on #EoE during #OIT from CHOP researchers Tim Buckey, Antonella Cianferoni, and others! pubmed.ncbi.nlm.nih.gov/41763603/

Eosinophilic Esophagitis Incidence during Single and Multiple Food Oral Immunotherapy - PubMed

In a cohort of 1200 children on OIT at a tertiary pediatric hospital with robust OIT and EoE programs, the rate of newly diagnosed EoE during OIT was found to be 0.7%, which is lower than prior studies. This study demonstrated regular screening before and during OIT is associated with a reduced rate …

pubmed.ncbi.nlm.nih.gov

Excited to attend the #AAAAI26 foundation benefit tonight. What an important event that is central to supporting so many advances in allergy and immunology!

Go see Hill Lab member Natasha Puzon‘s #AAAAI26 poster presentation on how #diet influences #asthma right now!

Go see Hill Lab member Julie Dilollo‘s #AAAAI26 poster presentation on #EoE T cells right now!

Come see past Hill Lab member and current CHOP A/I Assistant Professor Stan Gabryszewski give his talk on Artificial Intelligence in EoE at the CEGIR/TiGERS session right now! #AAAAI26

Come see Hill Lab member Julie give her oral abstract at the CEGIR/TiGERS session right now!

What would your vote be?

Congratulations to all of the #AAAAI26 Foundation awardees!

Very excited for the first day of #AAAAI26! Welcome to Philadelphia!

What if dietary fat acts as an immune signal? In our new review, we explore how saturated fatty acids activate conserved inflammatory pathways, shape immune cell function, and may represent an evolutionarily conserved host defense mechanism. Look for it soon in DNA and Cell Biology!

🎉 Excited to share that our newest manuscript has been accepted in @insight.jci.org! We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity! Stay tuned! #obesity #immunometabolism #macrophages #adiposetissue

2026 is off to a great start...🚨New publication alert!🚨 Our latest paper is out in Diagnostics! 🧬 We show that functional T-cell blood tests accurately predict milk and soy allergy in EoE, an important step towards a clinical test! 🔗 Read the full paper here: www.mdpi.com/2075-4418/16...

Had a great time at the #GordonFoodAllergy conference last week! What a wonderful community of highly dedicated investigators!

The CHOP Allergy and Immunology Division has a new recent publications board! Look at all that new knowledge… but the best is yet to come!