Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! www.biorxiv.org/content/10.1...

📢 @bayraktarlab.bsky.social & colabs at @sangerinstitute.bsky.social are assembling the @opentargets.org funded Neuroimmune Team 🧠🧬-Leverage AI to uncover neurodegeneration Tech Spec: sanger.wd103.myworkdayjobs.com/en-US/Wellco... Postdoc AI: sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Very excited to see this work comes out ad preprint! An elegant strategy discovering novel recessive signals in Exome sequencing dataset of the British South Asian population 🧬 #bioinformatics #exome #DNA #datascience #genomics #genetics

Georgios (Yiorgos) Kalantzis@yiorkala.bsky.social · last yr.

Preprint alert! 🚨 doi.org/10.1101/2025... Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social! We present several great results, and I’m thrilled to highlight the pieces I worked on:

Analyzing your single-cell data by mapping to a reference atlas? Then how do you know the mapping actually worked, and you’re not analyzing mapping-induced artifacts? We developed mapQC, a mapping evaluation tool www.biorxiv.org/content/10.1... from the ‪@fabiantheis lab. Let’s dive in🧵

Amazing work by the GBM-SPACE team atlassing one of the deadliest cancers #glioblastoma at multimodality, & coupled the elegant scDORI framework. These studies reveal a high-resolution spatiotemporal cell trajectory from tumour heterogeneity & plasticity at both cellular and molecular levels

Omer Ali Bayraktar@bayraktarlab.bsky.social · last yr.

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

Ever wondered what a snapshot of single-cell/spatial dataset can reveal? scCellFie - a scalable tool that goes beyond gene expression, making metabolic analysis possible 3-2-1, Say GENES 🤳 PREPRINT: doi.org/10.1101/2025... DOWNLOAD: sccellfie.readthedocs.io #DataScience #Bioinformatics #Spatial

Erick Armingol@erickarmingol.bsky.social · last yr.

I’m happy to share that our scCellFie manuscript is finally on bioRxiv — a project that was an amazing opportunity to return to my roots in metabolism! We infer metabolic activity from single-cell & spatial transcriptomics 🧬 Read the pre-print here👇 📄 doi.org/10.1101/2025...

We are delighted to announce a new collaboration between HCA and @UNESCO.org to help advance open science, global capacity and ethical frameworks to deliver the benefits of genomics at a global scale. www.humancellatlas.org/news/the-hum...

Absolutely over the moon to share our COVID-19 study is now featured on @naturecomms.bsky.social Editors’ Highlights for Microbiology & Infectious Diseases! Huge thanks to Sonja Schmid for choosing our work as one of the 50 BEST papers in this field. 💡Check it out: www.nature.com/collections/...

Microbiology and infectious diseases

This page highlights recent articles on all aspects of bacteriology, mycology, parasitology and virology, covering the biology of pathogens, host-pathogen ...

nature.com

Jimmy Lee@drjimmylee.bsky.social · last yr.

Thrilled to share our new @naturecomms.bsky.social study with @sam-n-barnett.bsky.social on early vs late #COVID19 lung damage 🫁. Using single-cell & histopathology-informed #SpatialTranscriptomics, we uncovered key biomarkers & immune patterns. Thanks to collaborators, UKCIC & @humancellatlas.org

If you have experience in sc/spatial transcriptomics with an interest in microbes....come and join our team as a computational postdoc: sanger.wd103.myworkdayjobs.com/WellcomeSang... Incredibly exciting datasets on host-microbe interactions in the lung. Pls RT and reach out if you are interested.

Thrilled to share our new @naturecomms.bsky.social study with @sam-n-barnett.bsky.social on early vs late #COVID19 lung damage 🫁. Using single-cell & histopathology-informed #SpatialTranscriptomics, we uncovered key biomarkers & immune patterns. Thanks to collaborators, UKCIC & @humancellatlas.org

Wellcome Sanger Institute@sangerinstitute.bsky.social · last yr.

How lung damage worsens during COVID-19 has been mapped at a cellular level. 🦠 By understanding how our lungs respond to the virus over time, this new knowledge may help identify future therapies for COVID-19. www.sanger.ac.uk/news_item/ce...

Absolutely Amazing!!

Maria Brbic@mariabrbic.bsky.social · last yr.

Thrilled to share LUNA🌕 – our new generative AI model that reassembles tissue structures from dissociated cells! LUNA learns spatial priors over existing spatially resolved datasets with the aim to predict cell locations de novo. Check out our paper here: www.biorxiv.org/content/10.1...

It was a pleasure to give a talk at the #HCA2024Asia @humancellatlas.org meeting. I really enjoyed catching up with some @sangerinstitute.bsky.social alumni and had some fascinating discussions with amazing scientists!! #HumanCellAtlas #Neuroscience #SingleCell #Bioinformatics

The integrated transcriptomic cell atlas of human neural #organoids, Barbara Treutlein's lab, @fabiantheis.bsky.social @graycamplab.bsky.social @sergiuppasca.bsky.social @giorgiaquadrato.bsky.social and colleagues: www.nature.com/articles/s41...

An integrated transcriptomic cell atlas of human neural organoids - Nature

A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...

nature.com