Bigger story? The Japanese company marketing Tavneos, Kissei - has told docs to stop using Avacopan WSJ story (Apple News link; apple.news/A8Woi0mr1QIm...)
Matt Luther, MD MSCI
@drjmluther.bsky.social
Nephrologist, Hypertension specialist, Physician-scientist.
Chronotherapy in the news again? @medscape.com discusses the story so far with the new ONAM study www.medscape.com/viewarticle/... @drlabos.bsky.social feat Scott Garrison and moi #Hypertension
Are BP Meds More Effective if Taken at Night?
The OMAN trial reignited the debate on whether it makes a difference clinically if antihypertensives are taken in the morning or the evening. Cardiologist Chris Labos reviews the evidence.
medscape.com
Hypertension Secrets has been translated into multiple languages, including Lithuanian! Get your copy here: shop.elsevier.com/books/hypert... @edgarvlermamd.bsky.social @drjmluther.bsky.social
The CPC from last @ahascience.bsky.social #HypertensionSessions now published in @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/... thanks to @drjmluther.bsky.social and all the education editors for the invite We hope it makes for an educational read!
New 2025 AHA/ACC Hypertension Guideline dropped! www.jacc.org/doi/10.1016/... #hypertension #medsky #nephsky
2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College o...
jacc.org
#LaskerLaureate Rustom Jal Vakil was born #OTD in 1911. He won a #LaskerAward in 1957 for his studies on the use of reserpine in the treatment of #hypertension. ow.ly/bFTR50FunRI 🧪
Treatment of hypertension - Lasker Foundation
Explore All 1957 Winners & Awards > Rustom Jal VakilKing Edward VII Memorial Hospital, Bombay For studies on the use of reserpine in the treatment of hypertension. The story of Rauwolfia…
ow.ly
New PA Endo guideline is also out by experts @anandvaidya17.bsky.social #Cardiosky @hswapnil.medsky.social doi.org/10.1210/clin...
Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline
AbstractBackground. Primary aldosteronism (PA), a primary adrenal disorder leading to excessive aldosterone production by one or both adrenal glands, is a
doi.org
The first #ERA25 simultaneous pub CONFIDENCE trial of empagliflozin + finerenone in N = 579 Greater reduction in ACR and BP Note the impressive GFR dip www.nejm.org/doi/full/10....
Plenary at @hypertensioncanada.bsky.social with @drjmluther.bsky.social on new drugs He starts of with the really old drugs! #CHC25
Phase 2 trial of the new antihypertensive agent, ultra-long-acting (q6 month), subq, small interfering RNA against angiotensinogen (Zilebesiran), hit JAMA! h/t @drjmluther.bsky.social jamanetwork.com/journals/jam... 1/
Add-On Treatment With Zilebesiran for Inadequately Controlled Hypertension
This randomized clinical trial examines the efficacy and safety of zilebesiran vs placebo when added to a standard antihypertensive medication in adult patients with uncontrolled hypertension.
jamanetwork.com
Matt Luther, Nephrologist/HTN specialist COI: Mineralys consulting #NephJC
Today we presented detailed results from our pivotal Ph3 Launch-HTN trial at #ESH2025, reinforcing the promise of lorundrostat as a new treatment approach for aldosterone driven #hypertension. Read our press release to learn more: ir.mineralystx.com/news-events/... $MLYS #bloodpressure
There you have it: BEDMED published in @jama.com jamanetwork.com/journals/jam... h/t @drjmluther.bsky.social No difference in bedtime versus morning BP meds - as expected #NephSky #Hypertension 1/
Aaand it’s official, we have a new antihypertensive class!!!! 🎉🍾🎊 I like this RCT design in particular because it was open to both uncontrolled not-yet-resistant AND resistant hypertensive patients, opening to door to prescribe it as an earlier line agent www.nejm.org/doi/full/10....
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...
nejm.org
The ASIs have arrived www.nejm.org/doi/full/10.... Aldosterone synthase inhibitors - first one to finish the phase 3 line #Lorundrostat #Hypertension
Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension | NEJM
Aldosterone dysregulation contributes to hypertension. Lorundrostat is an aldosterone synthase inhibitor, but data on its efficacy and safety in patients with hypertension are limited. In this mult...
nejm.org
How often have you seen Ferric Carboxymaltose cause hypophosphatemia? @kidneyboy.bsky.social @hswapnil.medsky.social @askrenal.bsky.social #askrenal pubmed.ncbi.nlm.nih.gov/39659775/
In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution - PubMed
Iron deficiency anemia is treated by iron supplementation. Increasing evidence has shown that the carbohydrate components in iron infusions can cause hypophosphatemia and subsequent osteomalacia due t...
pubmed.ncbi.nlm.nih.gov
Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization bit.ly/3CEO9n1 #OpenAccess
We showed a dramatic difference (dramatic for a small sample size!) in the effect of CTD vs HCTZ on urine calcium. That's my preference for stone prevention. RCT with stone outcome needed. pubmed.ncbi.nlm.nih.gov/40194294/
Effect of Chlorthalidone and Hydrochlorothiazide on Twelve-Hour versus Twenty-Four Hour Urinary Calcium Excretion - PubMed
We conclude that the long-acting and more effective CTD is a preferable agent for stone prevention. Time of administration does not appear to be important, although morning administration may more eff...
pubmed.ncbi.nlm.nih.gov
Retatrutide (GLP, GIP, Glucagon receptor agonist) and albuminuria and GFR changes from phase 2 trial now in @kireports.bsky.social Two Ph2 trials, one in T2DM and another in Obesity with about N ~ 300 each uACR reduced in both RCTs (A, B) Much more pronounced when baseline > 30 mg/g (C, D) 1/
behold the CONNECTED SPLATTERPIE kneel before my works, ye mighty, and despair
Matthew Kay@mjskay.com · last yr.it just occurred to me the obvious next step here is a connected scatterpie
Great pearls by @jbrianbyrd.bsky.social in evaluating pts for RDN at #ACC25: 1. confirm uncontrolled HTN with out of office measure (Amb BP monitor); 2. trial spironolactone 1st; 3. shared decision making key - care team should include HTN specialists beyond those performing the procedure #cardiosky
From @spjuraschek.bsky.social et al in the @bmj.com www.bmj.com/content/388/... Orthostatic #hypertension seems bad, but lowering BP intensively also lowers this #NephSky
Effects of intensive blood pressure treatment on orthostatic hypertension: individual level meta-analysis
Objective To determine the effects of intensive blood pressure treatment on orthostatic hypertension. Design Systematic review and individual participant data meta-analysis. Data sources MEDLINE, Em...
bmj.com
Chloride depletion alkalosis (as opposed to what was previously called 'contraction alkalosis') #Nephpearls #NephSky 👉🏼 pubmed.ncbi.nlm.nih.gov/22223876/
🧵 I’m excited to share our latest preprint! We studied 252 SCN5A variants found in patients with Brugada Syndrome by automated patch clamp. [1/7]
Our #rFSGS biobank is growing and we welcome patients from all over the world! Please reach out to us if you are a patient or a physician caring for one. We are creating a resource for everyone to use with the goal of resolving this disease and find new cures. #KidneyMonth2025 #RareDisease #genetics
rFSGS Initiative@rfsgsinitiative.bsky.social · last yr.Building a biobank is key to finding new treatments for Recurrent Focal Segmental Glomerulosclerosis. If you or someone you know has #rFSGS and you want to learn how you can help by providing a biosample, email mb5150@cumc.columbia.edu. #KidneyMonth #KidneyTransplant #nephsky #medsky #skyneph
#Quiz: A man in his 40s with untreated hypertension presented with right-sided neurologic deficits and slurred speech. His hypertension & age prompted investigation for a secondary etiology of his hypertension. What is the differential diagnosis? bit.ly/3gyO2ie (FREE)
Bladder Symptoms Provoked by Short, Rapid-Acting Loop Diuretics: A Frequent but Often Overlooked Problem academic.oup.com/ajh/article/... Dr. Wilcox and colleagues @gumedcenter.bsky.social
Dolly Parton's husband, Carl Dean, died on Monday. On Friday at midnight, Parton released the song "If You Hadn't Been There" in his memory.
Dolly Parton pays homage to late husband Carl Dean with 'If You Hadn't Been There'
Dolly Parton's husband, Carl Dean, died on Monday. On Friday at midnight, Parton released the song "If You Hadn't Been There" in his memory.
npr.org
DASH diet with low sodium lowers BP in DM, even when sglt2-i or glp-1 agonists are used! #epilifestyle25
