Wanpen Vongpatanasin

@drwanpen.bsky.social

Cardiologist, Hypertension Specialist, Gardener, Director of Hypertension Section & AHA Comprehensive Hypertension Center @UTSW

Among survivors of intracerebral hemorrhage, a single pill with three low-dose antihypertensive agents added to standard care was associated with a lower incidence of stroke and major cardiovascular events than placebo. Full TRIDENT trial results: nej.md/48eyAj1

Original Article | APR 23, 2026

Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage (TRIDENT)

Figure 2. Cumulative Incidence of First Recurrent Stroke (Primary Outcome).

The data is in: the NIH goalposts have shifted. What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards. Another manifestation of how HHS policies have led to fewer awards and less science.

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302

I was looking up the history of SGLT2 inhibitors and found this article on “phlorizinized men” and saw the first paragraph included “this evidence is direct and unequivocal in the case of the aglomerular fish” which made me double check the authors and sure enough there was Homer W. Smith

THE EXCRETION OF INULIN, XYLOSE AND UREA BY NORMAL AND PHLORIZINIZED MAN

An official website of the United States government

pmc.ncbi.nlm.nih.gov

Among patients with newly diagnosed or recent #LBP at moderate or high risk of chronicity, clinician-supported biopsychosocial self-management produced a greater proportion achieving ≥50% reduction in #disability over 12 months compared to medical care. ja.ma/4b86EiU

JAMA study: Spinal manipulation, self-management, and medical care for adults with acute or subacute low back pain (LBP). Results show the number of patients randomized in each therapy with findings on disability and pain.