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Katy Hole

@drkhole.bsky.social

Postdoc @crick.ac.uk | Investigating astrocyte-neuron intercellular mitochondrial transfer | Views are my own | She/her

6 Posts151 Follower368 Folgt
Katy Hole@drkhole.bsky.social · 6mo ago

So grateful that we were able to publish this work! We hope that this helps to inform the interpretation of existing intercellular mitochondrial transfer studies as well as the design of new experiments to improve #reproducibility in this rapidly expanding field!

Devine lab@devinelab.bsky.social · 6mo ago

⚡️We are excited to share a new paper from the lab by @drkhole.bsky.social in @cp-cellrepmethods.bsky.social - suggesting MitoTracker dyes are not a reliable tool for detecting intercellular mitochondrial transfer❗️ www.cell.com/cell-reports...

Devine lab@devinelab.bsky.social · 10mo ago

Check out the first review from the Mitochondrial Neurobiology lab on... lysosomes! Learn about the non-canonical roles of lysosomes in neurons from @jonnyspencer.bsky.social @ysudarikova.bsky.social: www.cell.com/trends/neuro...

Non-canonical roles of lysosomes in neurons

Neurons are highly polarised and compartmentalised cells with organelles that are specialised to support their spatial and functional demands. This includes lysosomes, which are single-membrane-bound ...

cell.com

Devine lab@devinelab.bsky.social · 10mo ago

Congratulations to Dr. Patrick Cottilli who has successfully defended his PhD viva yesterday!!🎉 This is a huge milestone for our lab - our first-ever PhD graduate!⭐ So proud of your hard work, creativity, and perseverance throughout these 4 years. Here's to the amazing science ahead!🔬

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Richard Sever@richardsever.bsky.social · last yr.

"Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer" www.biorxiv.org/content/10.1...

MitoTracker transfers from astrocytes to neurons independently of mitochondria

The neuroprotective transfer of mitochondria from astrocytes to neurons has been primarily investigated by labelling astrocytic mitochondria with the dye MitoTracker. Here we report that MitoTracker transfers to neurons from both astrocytes and astrocyte-conditioned media, independently of mitochondrial transfer. Our observations should prompt an essential re-evaluation of the literature concerning astrocyte-neuron mitochondrial transfer and in other systems in which contact-independent transfer has been observed using mitochondrial dyes. ### Competing Interest Statement The authors have declared no competing interest. MSD (United Kingdom), https://ror.org/004nn4n27, PRJ_20446 DEVINE MSD MRC The Francis Crick Institute, https://ror.org/04tnbqb63, CC2206

biorxiv.org

Neuron@cp-neuron.bsky.social · last yr.

Online now:

The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactions

Wu et al. used extracellularly displayed horseradish peroxidase (HRP) to label cell-surface proteins (CSPs) of astrocytes and neurons. By mapping CSPs to their origins, they report shared interactions between astrocytes and neurons, as well as extensive interactions of astrocytes with other parenchymal cells. They provide a foundation for exploring astrocyte-neuron interactions in health and disease.

dlvr.it

James Conway@drjamesconway.bsky.social · last yr.

New topical review from Verity Mitchener, Mille Thackray and Lorena Arancibia-Cárcamo of @ukdri.ac.uk on the glia-immune network in health and disease, with a focus on how astrocytes and oligodendrocytes coordinate microglia in Alzheimer's disease pathology

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

Abstract figure legend The glia-immune network involves the communication(s) of glia via immune signalling pathways. In neuro-homeostasis these pathways have been shown to modulate key processes such...

physoc.onlinelibrary.wiley.com