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Meng Wang

@drmengwang.bsky.social

Assistant Prof at Cornell University studying metabolism and DNA damage in cancer and aging. Alum of Cambridge and MRC-LMB. Dad!

19 Posts588 Follower381 Folgt
Meng Wang@drmengwang.bsky.social · 12mo ago

New publication from our lab! It was really fun writing this review @jcb.org with my postdoc Dr. Chris Mellor and graduate student Elisabeth Larson. We explore how folate deficiency trigger DNA damage that disrupt genome stability.

Journal of Cell Biology@jcb.org · 12mo ago

New review: Mellor, Larson, and @drmengwang.bsky.social discuss the molecular mechanisms of mammalian genomic instability arising from folate deficiency and how this impacts genome biology in health and disease. rupress.org/jcb/article/... #CellMetabolism

Rosado lab@rosadolab.bsky.social · last yr.

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells

HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

science.org

Scott Delaney@scott-delaney.bsky.social · last yr.

NIH indirects case update: Hearing ongoing now, and I'll try to live tweet some notable exchanges. Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides: (I'm paraphrasing here)

I
Immunominutes@cindyleifer.bsky.social · last yr.

It’s day 1 of the cut to NIH indirects and universities are scrambling to adapt. I’m going to post a series of videos on all the things I take for granted, but are both vital to research and covered by indirects for research grants.

Carl T. Bergstrom@carlbergstrom.com · last yr.

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

grants.nih.gov

Meng Wang@drmengwang.bsky.social · last yr.

Yes, doubleplusgood. Me writing my untruth grant in 2025.

a man sits in front of a large screen with a picture of a man on it

ALT: a man sits in front of a large screen with a picture of a man on it

media.tenor.com

Darby Saxbe@darbysaxbe.bsky.social · 2y ago

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

list of banned keywords
Ana Tufegdzic Vidakovic@anatv.bsky.social · 2y ago

The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! www.cell.com/molecular-ce...

CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription

Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.

cell.com