The ad is still open - if you are interested in structural biology of new RNA Pol II regulators, check out the postdoc position below 👇

Ana Tufegdzic Vidakovic@anatv.bsky.social · 4mo ago

We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below: www.nature.com/naturecareer...

We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below: www.nature.com/naturecareer...

Postdoctoral Scientist | PNAC | Dr Ana Tufegdzic Vidakovic | LMB 2142 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12857096

Postdoctoral Scientist Salary £42,694 per annum pro rata Fixed term for 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Applications are...

nature.com

We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab. @mrclmb.bsky.social Please get in touch if you have any questions. www.nature.com/naturecareer...

Research Group Leader Tenure Track - Structural Studies - LMB 2775 - Cambridge, Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854636

Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...

nature.com

Sjors Scheres@sjorsscheres.bsky.social · 6mo ago

Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳 mrc.tal.net/vx/mobile-0/...

How did life arise from simple chemical building blocks? New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer. Read more: mrclmb.ac.uk/news-events/...

It was great fun collaborating with Scott Berry's lab, as always! @scottbscience.bsky.social @cftbla.bsky.social Wonderful to see this work online 🧪 🔬 🧫! How cells respond to changes in RNA Pol II abundance 👇

Scott Berry@scottbscience.bsky.social · 7mo ago

What happens when you suddenly remove half of an essential enzyme from cells? 🤔 We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint 👇 bit.ly/4pyPgax

We have an opening for a research support officer. Come and join us! Please share.

MRC Laboratory of Molecular Biology@mrclmb.ac.uk · 8mo ago

Are you an enthusiastic and ambitious scientist looking for a challenging project? Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance! Apply by 11 JAN www.jobs.ac.uk/job/DPU715/r...

Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments? Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation doi.org/10.64898/202...

An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...

SET1/MLL complexes control transcription independently of H3K4me3

Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

biorxiv.org

Happy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II: www.biorxiv.org/content/10.6...

Stalling of elongating Pol II triggers Ser7 phosphorylation in trans to drive transcription recovery

DNA is scattered with obstacles that stall RNA polymerase II (Pol II) and block the production of full-length transcripts. Two mechanisms are known to resolve stalled Pol II: transcription-coupled nuc...

biorxiv.org

It is a privilege to join the international EMBO community and I look forward to meeting and exchanging ideas with fellow EMBO investigators! I am most grateful to my fantastic lab members who made this possible. 🧪🧫 🧬

EMBO@embo.org · 8mo ago

Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/

Our dxChIP-seq protocol is now online! If you have a difficult chromatin target, you may want to give it a try (it also works for "easy" targets such as Pol II and histones). www.sciencedirect.com/science/arti...

@mrclmb.bsky.social MRC LMB is looking for a new group leader in Chemical/Synthetic Biology. Come and join us in this fantastic institute! Core funding, amazing science all around you and great collaborative colleagues are just some of the highlights. Please share the news!

Phil Holliger@philholliger.bsky.social · last yr.

We are looking to recruit a tenure track group leader in the field of Chemical/Synthetic Biology (in the broadest sense) to lead a research program within the Division of Protein & Nucleic Acid Chemistry ( www.jobs.ac.uk/job/DNW809/r... ) at the MRC Laboratory of Molecular Biology (LMB).

Looking forward to presenting at the Cambridge RNA club again! If you are interested in gene regulation and around Cambridge, stop by!

Cambridge RNA@cambridgerna.bsky.social · last yr.

Ever wondered how RNA polymerase II gears up to tackle obstacles on DNA? Turns out, cells have a preparation pathway, and it’s way cooler than we imagined! Join us and @anatv.bsky.social on June 26th to discover how Pol II gets battle-ready! 💥🧪 #RNAClub

~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay Come join us for a fun time and invigorating scientific discussions in Vienna! meetings.embo.org/event/25-rna...

RNA meets protein decay

Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…

meetings.embo.org

The first PhD student of our lab, 5'-Ivan Shlamovitz, has passed his viva with flying colours! What a special moment! The whole lab (and many friends at the LMB) are proud! 👏😁

The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! www.cell.com/molecular-ce...

CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription

Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.

cell.com