Fresh from the oven! Our new perspectives article where we discuss the interplay between lagging strand DNA replication and the replication stress response. An updated view on lagging strand DNA replication: implications for the replication stress response www.tandfonline.com/doi/full/10....

An updated view on lagging strand DNA replication: implications for the replication stress response

The process of DNA replication is inherently asymmetric. While the leading strand is synthesized continuously, the lagging strand is copied in small fragments, the Okazaki fragments, requiring the ...

tandfonline.com

First-ever meeting on "DNA-Protein Crosslinks" in genome instability and disease. Superb line-up of speakers awaits. Short talks selected from abstracts. Send yours today and join us for an engaging discussion! Please RT!! 📆 Nov 18-20th 2026 📍 Baeza, Andalucia, Spain www.unia.es/estudios-y-a...

In memoriam of Dr. Enrique Cerdá Olmedo, a life full of scientific achievements.

Amazing 3rd FA Europe Meeting at beautiful Gdansk in Poland! Great scientific discussion about FA biology, bone marrow function and SCC tumour teatembt and prevention!!

La vicerrectora de Investigación y el vicerrector de Internacionalización han asistido al acto en el Palacio Real de Pedralbes. www.us.es/actualidad-d...

Dos investigadores sevillanos recogen los premios nacionales de investigación, 2025

Los investigadores Andrés Aguilera, catedrático del Departamento de Genética de la Universidad de Sevilla y miembro de CABIMER, y Jesús Campos Manzano, investigador del CSIC en el Instituto de Investi...

us.es

Superb kickoff of the Quinquennial DDR meeting 2026 by an amazing keynote lecture by Johannes Walter followed by Simon Boulton. Great science!!

Pleased to share our review on chromosomal instability (CIN) and aneuploidy in cancer, led by Amanda Mennie. Now out @annualreviews.bsky.social! www.annualreviews.org/content/jour...

Impact of Chromosomal Instability and Aneuploidy in Cancer Development

Somatic human cells contain a diploid genome consisting of 23 pairs of chromosomes. The maintenance of this diploid state is essential across all layers of biological organization, ranging from the ph...

annualreviews.org

Yaiza and Lucia from our lab present their data on "POLL-driven 5hmdU misincorporation in FA cells" at the 2nd SECRIS symposium for early Career investigators. Congratulations!

We are celebrating our research institute @cabimer.bsky.social 20th anniversary!! Superb list of speakers!! And attendees!!

www.nature.com/articles/s42... Congrats @jourdainlab.bsky.social & team!!

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...

nature.com

#ÚLTIMAHORA | Muere a los 91 años la etóloga británica Jane Goodall

Muere a los 91 años la etóloga británica Jane Goodall

La etóloga británica Jane Goodall ha fallecido a los 91 años de edad en la ciudad estadounidense de...

europapress.es

Our new study supports that aging begins in the early stages of embryo development, and not only in adulthood @canalugr canal.ugr.es/noticia/a-ne...

A new study suggests that aging begins in the early stages of embryo development, and not only in adulthood - Canal UGR

This work by the University of Granada, published in Nature Communications, opens up a new paradigm in biomedicine by examining the role of the BMAL1 protein in aging and the… Seguir Leyendo A new stu...

canal.ugr.es

congratulations to our DB colleague Maria Jasin, recognized by the Greengard Prize! when she started her lab @mskcancercenter.bsky.social, she was the first to insert DNA into a defined location of a mammalian genome! her work underlies today's CRISPR-mediated HDR. here in convo with Rick Lifton.🧬

The Rockefeller University @rockefeller.edu · 11mo ago

Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience

Si quieres hacer una tesis doctoral en tumorogenesis asociada a la inestabilidad genética, contáctanos!! Please RT!!

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it! Now online here 👇🏼 academic.oup.com/nar/article/...

S-phase checkpoint protects from aberrant replication fork processing and degradation

Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

academic.oup.com

Happy to see this out, great work from Niels, combining kinetic analysis, cryoEM and an unexpected gain-of-function mutant, nice work from master students Jan and Nina, from Kaustav and from Alex for the kinetics ‪@oncodeinstitute.bsky.social‬, ‪@nkinl.bsky.social‬

Niels Keijzer@nkeijzer.bsky.social · last yr.

I'm very proud that our paper, and with that the main project of my PhD, has just been published by @natcomms.nature.com! 🎉 Here, we reveal the unique, molecular mechanism by which USP1/UAF1 cleaves ubiquitin chains on PCNA, which may direct DNA damage tolerance. doi.org/10.1038/s414...

A study in Nature shows that respiratory viruses trigger metastatic breast cancer cells to proliferate in lungs in mouse models of breast cancer. These findings are supported by human observational data. go.nature.com/4l7NZ8l #medsky 🧪

One often hears that DNA is the blueprint of life. Today, I read a really nice paper that begins with "proteins are the cornerstone of life". By that logic, I might start referring to RNA as the scaffold, and chromatin as the framework that shapes it all. Regardless, the paper is a must-read:

Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures

Proteins are the cornerstone of life. However, the proteomic blueprint of aging across human tissues remains uncharted. Here, we present a comprehensi…

sciencedirect.com

My grant application to follow up my research line has preliminary been accepted. Thanks to those involved in peer reviewing and to @CienciaGob for this great news! Let's keep science moving!!!

🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇

Cassie Clarke@cassiejclarke.bsky.social · last yr.

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Now peer reviewed and in its final form @natcomms.nature.com www.nature.com/articles/s41...

Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability - Nature Communications

The DNA-dependent protease SPRTN cleaves toxic DNA-protein crosslinks (DPCs). Here, the authors show that SPRTN is activated by DPC-ubiquitylation through an allosteric ubiquitin binding interface. Th...

nature.com

Julian Stingele@jstingele.bsky.social · 2y ago

Happy to share our latest work🍾 🥳 PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧

New #preprint from the lab! Do you want to see the invisible? So did we! When DNA genomes get broken, cells somehow find related sequences to fix the break. But how do they find it? We developed a way to look at sequence *search*, not just sequence usage. doi.org/10.1101/2025...

🔴La convocatoria “Consolidación Investigadora” de este año vuelve a sufrir un recorte 📉Es un 50% menos que 2024, que a su vez ya fue recortada otro 50% respecto a 2023 👉¿Consecuencia? Aún más problemas para la estabilización @cienciagob.bsky.social @ageinves.bsky.social @dianamorantr.bsky.social 🧵

Really cool new cryoEM structure of RAD51 caught in the act of recombination initiation at a D-loop. elifesciences.org/reviewed-pre...

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

Postdoctoral Research Associate in the Blackford Group

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

candidate.hr-manager.net

This is the reason why voting for right-hand parties must never be a choice! You 'll never know what they are capable of...

Dr. Sven-Eric Jordt #TobRegSky@sejordt.bsky.social · last yr.

NIH stops development of HIV vaccine, terminates grants to consortia, including at Duke University. www.science.org/content/arti...

What is the E3 ligase/Deubiquinating enzyme for your protein?😁👇 UbiBrowser 2.0: a proteome-wide known & predicted E3/DUB-substrate interactions (~4k/1k & 1900k/300k) database in 39 eukaryotic species ubibrowser.bio-it.cn/ubibrowser_v... #NucAcisRes 2022 academic.oup.com/nar/article/...

What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social Published today: www.nejm.org/doi/full/10....

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM

Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

nejm.org

Children's Hospital of Philadelphia@childrensphila.bsky.social · last yr.

CHOP & @pennmedicine.bsky.social have delivered the first-ever personalized gene editing therapy for a patient with CPS1 deficiency, marking a major milestone in the application of CRISPR-based treatments. Learn more about KJ & the future of personalized medicine: www.chop.edu/news/worlds-....

Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi www.diariodesevilla.es/sevilla/inve...

Investigadores sevillanos descubren un mecanismo que causa fragilidad cromosómica en la anemia de Fanconi

El hallazgo ha sido liderado por el departamento de Genética de la Universidad de Sevilla y el Instituto Cabimer

diariodesevilla.es