Reschke lab

@drrobinreschke.bsky.social

Max-Eder Research Group Leader & Physician Scientist @NCT @DKFZ @DKTK @Uniklinik_HD TRYTRAC @CancerCoreEurope before PostDoc @Uchicago Gajewski lab #skin #cancer #immunology #spatialbiology #dermatology

🧪✨ Can we predict immunotherapy toxicity before treatment starts? Our new study says: yes. Baseline autoantibody profiles predict irAEs & colitis in melanoma—and differ by PD-1 vs CTLA-4 therapy. Toward safer, personalized checkpoint inhibition. Open access 🚀: jitc.bmj.com/content/14/1...

Autoantibodies as predictors for immune-related adverse events in checkpoint inhibition therapy of metastatic melanoma

Background Immune checkpoint inhibitors have transformed melanoma therapy but frequently cause immune-related adverse events (irAEs), including colitis, that limit treatment. Reliable biomarkers predi...

jitc.bmj.com

Big thanks to the Society for Investigative Dermatology for an amazing meeting in San Diego so far! Honored to receive an award for our work and the invitation to present 🥳Grateful for the inspiring science, conversations, and community! ☀️#SID2025#DermResearch  @siderm.bsky.social

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🚨New research highlight: study on managing immunotherapy side effects without weakening anti-tumor power! ECP reduces harmful immune activity via neutrophils/T cells & promotes M2 macrophages via adiponectin. Promising results from Zeiser et al. 🔬 🧪 🧫 Full summary: www.nature.com/articles/s41...

Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities

nature.com

⚠️ Anti-PD1 therapy could serve as an effective systemic treatment for patients with basal cell nevus syndrome who are resistant to hedgehog inhibitors, leveraging the immune system to address new occurrences of basal cell carcinoma 💡🧠🔬. 🔗 Read the full study here: jamanetwork.com/journals/jam...

Use of Anti-PD1 Blockade After Hedgehog Inhibitors or as First-Line Therapy for Gorlin Syndrome

This case series examines treatment with anti–programmed cell death 1 (PD1) immunotherapy for patients with basal cell nevus syndrome.

jamanetwork.com