Javier Oliver
@javiom.bsky.social
Biologist & Human Geneticist/Genomicist working on pharmacogenomics and oncology to enable Precision Medicine. Alumni UGR, CSIC. Ex ENS-LYON, IARC, HIBA. Currently PI at IBIMA/HUVV
Virtual cells for predictive immunotherapy - @fertiglab.bsky.social @genomescience.bsky.social go.nature.com/4jfqM3Y
www.nature.com/articles/s41...
Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities
nature.com
www.nature.com/articles/s41...
The complexity of tobacco smoke-induced mutagenesis in head and neck cancer - Nature Genetics
Whole-genome sequencing and mutational signature analysis of 265 head and neck cancer samples collected from eight different countries provide insight into the vital contribution of tobacco smoke in disease etiology.
nature.com
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) enable degradation of proteins involved in cancer growth. The efficacy of PROTACs depends on cellular factors that may enable or prevent target degradation. Wo...
cell.com
journals.plos.org/plosone/arti...
A genomics learning framework for undergraduates
Genomics is an increasingly important part of biology research. However, educating undergraduates in genomics is not yet a standard part of life sciences curricula. We believe this is, in part, due to...
journals.plos.org
www.nature.com/articles/s42...
The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases - Communications Biology
The study uses GWAS for 40 circulating cytokines in meta-analyses of 74,783 individuals. With Mendelian randomization, key cytokines like G-CSF/CSF-3 and CXCL9/MIG are identified as potential causal m...
nature.com
It's craaazy that chemo has been in the clinic for so long, yet its therapeutic index remains incompletely understood. In this #Perspective, Letai & de The explore existing models + knowledge gaps, & suggest principles for optimizing dosing + scheduling. @natrevcancer.bsky.social bit.ly/3C53w8g
Conventional chemotherapy: millions of cures, unresolved therapeutic index - Nature Reviews Cancer
Conventional chemotherapy has successfully cured millions of patients with cancer, yet the mechanisms of action for this remain unclear. In this Perspective, Letai and de The assess the existing mecha...
bit.ly
This year, the term “scientist” turns 190 years old! It was coined by William Whewell, who also considered the alternatives: “savant”, “philosopher”, “nature-poker”, and “nature-peeper” Did he choose the right one?
New principles for international genomic collaborations No more helicopter research, no more using and extracting resources without recognition to the local researchers and communities www.who.int/news/item/20...
WHO releases new principles for ethical human genomic data collection and sharing
The World Health Organization (WHO) has issued a set of principles for the ethical collection, access, use and sharing of human genomic data. Created with guidance from the WHO Technical Advisory Grou...
who.int
www.nature.com/articles/s41...
Five latent factors underlie response to immunotherapy - Nature Genetics
Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden,...
nature.com
Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...
Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature
Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.
nature.com
Anna Obenauf@obenaufa.bsky.social · 2y ago1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
www.nature.com/articles/s41... Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang
Next-generation combination approaches for immune checkpoint therapy - Nature Immunology
In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.
nature.com
www.nature.com/articles/s41...
The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution - Nature
Whole-genome sequencing of matched serial tumours from patients identifies two key mutagenic factors (APOBEC3 and chemotherapy) and extrachromosomal DNA-forming structural variants that driv...
nature.com
Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution. www.nature.com/articles/d41...
Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
Somatic mutation and selection at epidemiological scale
As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...
medrxiv.org
Inspired by the other amazing starter packs - here's one for cancer researchers! I tried to make this broad - from immunology to genomics to cell biology and so much more.. This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺 Hope its useful! go.bsky.app/FEoaJMc
A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...
