Excited to share our new study in @braincomms.bsky.social that seeks to use genetics to drive therapeutic innovation in amyotrophic lateral sclerosis (ALS) - with @zaccyg.bsky.social and several others. academic.oup.com/braincomms/a...

Drug repurposing candidates for amyotrophic lateral sclerosis using common and rare genetic variants

Gerring et al. report opportunities for drug repurposing in amyotrophic lateral sclerosis by leveraging large-scale genomic datasets. Their analysis priori

academic.oup.com

Exciting new PhD project available with me and Prof Kaylene Young that will use genetics to prioritise drugs that could combat progressive MS and then test them in iPSCs. Generous scholarship available (40,000 AUD per year) Please share around www.utas.edu.au/research/deg...

Check out our review out in Biological Psychiatry that digs into the fascinating area of the role of metabolic factors in the eating disorder anorexia nervosa @jgthorp.bsky.social Kirrily pursey www.biologicalpsychiatryjournal.com/article/S000...

Does the influence of low body-mass index on diagnosis complicate genetic studies of the role of cardiometabolic traits in liability to anorexia nervosa?

Anorexia nervosa (AN) is an eating disorder for which the underlying aetiology remains mostly uncharacterised. Large-scale genetic studies of AN suggest a relationship between AN liability and cardiom...

biologicalpsychiatryjournal.com

This paper was a long time coming, happy to see it out today in @naturecomms.bsky.social: www.nature.com/articles/s41... We found some interesting links between genetic regulation of blood cell traits and #glioma risk + survival, pointing to #immune related mechanisms 🧠🧬

Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival - Nature Communications

Glioma is an aggressive brain tumor subtype with few known risk factors. Here, the authors utilise Mendelian Randomisation to investigate correlation of immune cell counts with subtype-specific risk a...

nature.com

Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: nature.com/articles/s41...

Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity - Nature Communications

Circuit and cell type prioritization for complex disorders is crucial to direct future efforts. Here the authors integrate GWAS, human single-cell RNA-seq and fMRI analysis suggesting multi-modality c...

nature.com

New PhD opportunity in my group on an exciting motor neurone disease genetics project - scope also for both bioinformatics and lab work. Contact me if interested www.utas.edu.au/research/deg...

Genetics of motor neuron disease

utas.edu.au

Our study of genes, brains and #DYSLEXIA in over 30,000 adults from @ukbiobank.bsky.social is now published: www.science.org/doi/10.1126/... Brain regions especially involved in motor, language and vision functions are associated with genetic disposition to dyslexia. Thread below ⬇️ 1/8

Great discussions at the #NARF AGM and presentation from NARF postdoc award recipient @drwilliamreay.bsky.social We will keep advocating for #biomedicalscience, robust #peerreview and more funding #discoveriesneeddollars Looking forward to continuing our work in 2025 and representing the sector

Great and extremely innovative new preprint led by Jackson Thorp and Andrew Grotzinger - so many useful applications of this!

Jackson Thorp@jgthorp.bsky.social · 2y ago

New preprint! www.medrxiv.org/content/10.1... We introduce Genomic Network Analysis (GNA), a method to conduct network analysis on GWAS sumstats / estimate conditional genetic associations at multiple levels of analysis. @andrewgrotzinger.bsky.social @zaccyg.bsky.social @drwilliamreay.bsky.social