100% on this! Inspired by this piece in 2014 (www.nature.com/articles/nrn...; @clydefrancks.bsky.social @profsimonfisher.bsky.social), we've stopped excluding left handers about a decade ago and have never looked back. :)

Brock Kirwan@brockkirwan.com · 2mo ago

In honor of International Left-Handers Day, we have an updated preprint on scanning left-handed participants in fMRI studies. Although they're 11% of the population, we routinely screen LH people out of fMRI studies due to concerns about functional lateralization 1/n www.biorxiv.org/content/10.1...

Happy to share that our work is finally published in @commsbio.nature.com! We identify molecular and cellular signatures of hemispheric specialization, linking language and attention to distinct neurotransmitter, mitochondrial, & cellular organization across the cortex 🧠 doi.org/10.1038/s420...

Loïc Labache@loiclabache.cpesr.fr · last yr.

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence

Hemispheric specialization is core to brain organization, but its biological basis has been unclear. New @holmeslab-bhi.bsky.social paper links neurochemical & cellular asymmetries to left-lateralized language & right-lateralized attention networks, with implications for evolution & psych illness.

Loïc Labache@loiclabache.cpesr.fr · 3mo ago

Happy to share that our work is finally published in @commsbio.nature.com! We identify molecular and cellular signatures of hemispheric specialization, linking language and attention to distinct neurotransmitter, mitochondrial, & cellular organization across the cortex 🧠 doi.org/10.1038/s420...

Patterns of language and visuospatial Lateralisation in three-year-old children. Final version by Josephine Quin-Conroy & al. with @profsimonfisher.bsky.social @clydefrancks.bsky.social doi.org/10.1016/j.neuropsychologia.2026.109434

Patterns of Language and Visuospatial Lateralisation in Three-Year-Old Children. New paper by Josephine Quin-Conroy et al. with @profsimonfisher.bsky.social and @clydefrancks.bsky.social. doi.org/10.1016/j.ne...

New study: Population-wide variation in connectopic organization of cerebral language hubs www.biorxiv.org/content/10.6... Summary over on my LinkedIn account: www.linkedin.com/feed/update/...

New study: Brain language hubs examined with connectopic mapping in over 40,000 people: https://lnkd.in/eudABwGE For his final PhD study in my group at Max Planck Institute for Psycholinguistics and… ...

New study: Brain language hubs examined with connectopic mapping in over 40,000 people: https://lnkd.in/eudABwGE For his final PhD study in my group at Max Planck Institute for Psycholinguistics and D...

linkedin.com

Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis. New paper by @meng-yun.bsky.social & al. with Nicole Ying Ting Ng, Else Eising, @profsimonfisher.bsky.social , @clydefrancks.bsky.social doi.org/10.1007/s00429-026-03098-5

Structural and functional brain asymmetry in relation to heterogeneous causes of situs inversus totalis - Brain Structure and Function

Brain Structure and Function - Various aspects of brain organization differ between the left and right hemispheres. Clues to the developmental origins of these asymmetries may be gained through...

doi.org

It’s on LinkedIn: www.linkedin.com/posts/clyde-...

The wrong number of chromosomes in this supposed genetic study of human handedness suggests AI-generated nonsense (as do various other errors such as a fake reference attributed to yours truly, or… | ...

The wrong number of chromosomes in this supposed genetic study of human handedness suggests AI-generated nonsense (as do various other errors such as a fake reference attributed to yours truly, or 'tr...

linkedin.com

Seemingly fake genetic study of left-handedness, first drawn to my attention by @ocklenburg.bsky.social , with laughable / frighteningly bad figures and false citations...!

Michel Nivard@michelnivard.bsky.social · 8mo ago

@clydefrancks.bsky.social found what is potentially (likey?!) the first fully hallucinated GWAS paper, of “left handedness”… the Manhattan plot has the wrong number of chromosomes, and genes labels with one wrong chromosome placed in a second wrong chromosome… wild…

I joined the The Marie Skłodowska-Curie Actions Matchmaking Platform as a potential hosting group. Please be in touch if you might be interested to apply for a postdoctoral fellowship in the next round. Maybe you could join us and work on brain imaging genomics! www.b2match.com/e/radiance-m...

Integrating brain structure and function for the neurobiology and genetics of language www.biorxiv.org/content/10.6... New study in which @jsamelink.bsky.social examined brain data from >32,000 people from @ukbiobank.bsky.social ... 1/4 ⬇️

Evaluating the effects of archaic protein- altering variants in living human adults. New paper by Barbara Molz, Mikel Lana Alberro, Else Eising, Dick Schijven, @gokberkalagoz.bsky.social @clydefrancks.bsky.social @profsimonfisher.bsky.social. doi.org/10.1126/scia....

Evaluating the effects of archaic protein-altering variants in living human adults

Promise and pitfalls of using large biobanks to study impacts of archaic protein-coding variants in living humans.

doi.org

"Despite widespread claims linking gut health to autism spectrum disorder, a comprehensive analysis published in the journal Neuron has found no scientific evidence supporting the hypothesis that the gut microbiome causally contributes to autism."

No, Your Gut Microbiome Doesn't Contribute to Autism—New Study Dismantles Decades of Misleading Claims

A comprehensive analysis has found no scientific evidence supporting the hypothesis that the gut microbiome causally contributes to autism.

thedebrief.org

www.popsci.com/science/why-...

Why are most people right-handed?

A mix of biology, environment, and evolution helps explain our rightie-dominated world.

popsci.com

Asymmetries of the brain and body - are they linked genetically? In a new study we sequenced the genomes of people with their visceral organs reversed on the left-right axis, in a rare congenital condition called situs inversus totalis: www.biorxiv.org/content/10.1... Short thread below ⬇️ 1/5

CALL FOR INVESTIGATOR AWARD NOMINATIONS 2026 The International Behavioural and Neural Genetics Society Early Career Achievement Award and Distinguished Investigator Award DEADLINE: December 2nd, 2025 www.ibngs.org/ibangs-awards

New PhD program: the Max Planck Artificial Intelligence Network is.mpg.de/news/new-max...

New Max Planck Artificial Intelligence Network Starts Call for Applications for its Ph.D. Program

The Max Planck Artificial Intelligence Network is a Ph.D. Program that provides doctoral researchers with fully funded Ph.D. fellowships and a pool of outstanding faculty comprising directors and inde...

is.mpg.de

New @maxplanck.de study: We looked for left-right differences of gene expression and cell-type abundances in the brains of MICE 🐭using Xenium @10xgenomics.bsky.social. Possible clues to how functional brain asymmetry is supported !! www.biorxiv.org/content/10.1... Short thread below ⬇️

𝗕𝗿𝗮𝗶𝗻-𝘄𝗶𝗱𝗲 𝗰𝗼𝗺𝗽𝘂𝘁𝗮𝘁𝗶𝗼𝗻𝘀 Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice 𝗕𝗿𝗮𝗶𝗻 𝗿𝗲𝗴𝗶𝗼𝗻𝘀 𝗼𝗿 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝘁𝗵𝗿𝗲𝗮𝗱𝘀? Dynamical processing winding through most brain regions. Looks like a must read. www.biorxiv.org/content/10.1... #neuroskyence

Spatially distributed and regionally unbound cellular resolution brain-wide processing loops in mice

Until recently, it has been possible to examine activity in the brain globally through regional averaging or locally at cellular resolution. These studies characterized regions as functionally homogen...

biorxiv.org

Latest processing of UK Biobank brain imaging data - now with 82,000 usable first-scan datasets. Correlating brain IDPs with 13,000 non-imaging variables gives a rich manhattan-stye plot. 324,000 Bonferroni-significant associations.

Emergence of genetic variants linked to brain and cognitive traits in human evolution academic.oup.com/cercor/artic...

The emergence of genetic variants linked to brain and cognitive traits in human evolution

Abstract. Human evolution involved major anatomical transformations, including a rapid increase in brain volume over the last 2 million years. Examination

academic.oup.com

💥🧠🧬Finally out!! Our new paper on the overlapping genetic basis of brain structures and psychiatric disorders has been published in Nature Mental Health. The full list of shared genetic loci is also available online. Thank you so much, Aaron and all co-authors. www.nature.com/articles/s44...

The overlapping genetic architecture of psychiatric disorders and cortical brain structure - Nature Mental Health

This study highlights sex differences in major depressive disorder using resting-state functional magnetic resonance imaging. Findings suggest hormonal fluctuations influence onset, emphasizing the ne...

nature.com

Integrating and interpreting brain maps | doi.org/10.1016/j.ti... Imaging and recording technologies make it possible to map multiple biological features of the brain. How can these features be conceptually integrated into a coherent understanding of brain structure and function? ⤵️

Fascinating study suggests that left-right differences in the fly brain arise from asymmetrical twist of neurons www.biorxiv.org/node/4751792... Might also be true for human brains as we suggested here www.nature.com/articles/s41... after implicating microtubules in human structural brain asymmetry

Terrific new preprint charting structural brain asymmetry across the human lifespan By @aarona-b.bsky.social and collaborators 🧪🧠 www.biorxiv.org/content/10.1...

Charting structural brain asymmetry across the human lifespan

Lateralization is a fundamental principle of structural brain organization. In vivo imaging of brain asymmetry is essential for deciphering lateralized brain functions and their disruption in neurodev...

biorxiv.org

Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...

Nobel prize winner loses Dutch nationality...

🎥🌍 Over 1,000 neuroscience talks now free on YouTube and published at @apertureohbm.bsky.social. 🧠 “Now anyone, anywhere can binge-watch brain science like a box set,” says @stephforkel.bsky.social: www.ru.nl/en/donders-i... @alfiewearn.bsky.social @sitek.bsky.social @sofievalk.bsky.social

Global access to brain science: OHBM launches channel with 1,000+ talks | Radboud University

What if you could journey back in time to hear world-leading neuroscientists present the ideas that shaped today's brain science? A new open-access initiative led by researchers from the Donders Insti...

ru.nl

Plus, we've begun to uncover how DNA variants contribute to connectivity of language circuits in the human brain, via largescale genomic analyses of resting-state functional neuroimaging data. Check out this @commsbio.nature.com paper by @jsamelink.bsky.social @clydefrancks.bsky.social & co. 🧬🧠🧪7/n

Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness - Communications Biology

Common and rare genetic variants, as well as polygenic scores of dyslexia and handedness are associated with the functional brain language network and hemispheric differences within this network, shed...

nature.com

Ending the thread with one last illustration of novel avenues opened up by genomics of language-/reading-related traits. In a recent Science Advances paper, @clydefrancks.bsky.social's lab identified associations of dyslexia-disposing DNA variants with various aspects of human brain structure. 🧬🧠8/8

Distinct impact modes of polygenic disposition to dyslexia in the adult brain

Genetic disposition to dyslexia is associated with brain structure in the general population.

science.org