Jens Hjerling Leffler
@hjerling-leffler.bsky.social
Molecular Psychiatry, Neuroscience, Genetics, Professor at Karolinska Insitutet
Please RP! Excited to share our new preprint: “Single-cell chromatin tracing reveals multimodal molecular programs during memory formation” We built a single-cell multiomic atlas of aversive learning and used it to trace memory-linked molecular programs. doi.org/10.64898/202...
New preprint from our lab on bioRxiv: “Stoichiometric transcription factor partnerships control GABAergic neuron fate allocation” www.biorxiv.org/content/10.6... A great collaboration with @annrosebright.bsky.social, Connor Lynch, @chr-mayer.bsky.social, and many others.
Stoichiometric transcription factor partnerships control GABAergic neuron fate allocation
Combinatorial transcription factor (TF) codes specify neuronal fates, yet how quantitative differences in interacting TFs shape these decisions remains unresolved. We address this in the developing ba...
biorxiv.org
Scientists should be very careful with the term "reproducibility crisis". It is a (highly effective) tool to sow doubts by those who want to undermine science. There is no crisis; non-reproducible results are not ideal, they have always been part of the scientific process. Don't feed the beast.
It’s still unclear whether Hantavirus is scary enough to guarantee 1,000 publications in Nature
arXiv to spin out as an independent non-profit. They are seeking a CEO jobs.chronicle.com/job/37961678...
Chief Executive Officer - New York City, New York (US) job with arXiv | 37961678
arXiv seeks its first CEO to champion open, free scientific discovery and guide the platform’s next chapter as an independent nonprofit.
jobs.chronicle.com
BOOM! Fantastic new paper from Patrik Ernfors and his team: www.nature.com/articles/s41... Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis
Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis - Nature Neuroscience
Su et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggest...
nature.com
I am so happy for the recognition that my PhD supervisor and friend has received. Congratulations Patrik!
The Brain Prize@brainprize.org · 5mo agoWarm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain. Karolinska Institutet HHMI #Neuroscience #BrainPrize2026
Post-doc positions in my lab. Come join us in Stockholm! ki.varbi.com/en/what:job/... ki.varbi.com/en/what:job/...
A super intense and fantastic sunny week in Alicante discussing single cell and spatial omics in the CNS! Thanks all the students for lots of discussions, great flash talks and lots of fun in the social activities, the local organizers, aka @silviadesantis.bsky.social and my co-chair Ana Falcão.
🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓ 🧵3/3
🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠 She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨🎓
Our last, but by NO means least, group is the ✨Single Cell Transcriptomics✨group! Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠 🧵1/2
First paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1
The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS
Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...
rdcu.be
Margherita Zamboni@margheritazamboni.bsky.social · 8mo agoThrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS! www.nature.com/articles/s41... @ellorens.bsky.social @ki.se @natneuro.nature.com
Pet peeve: when someone invites you to a meeting but instead of sending a calendar invitation, they just send a zoom link in an email. If you want profs to actually show up for meetings-- send a calendar invitation! #AcademicSky #ScienceSky #MedSky #EpiSky
a netflix ad shows a woman in a blue dress
ALT: a netflix ad shows a woman in a blue dress
media.tenor.com
Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders rdcu.be/ePmwD
A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders
Nature Neuroscience - Smeland et al. demonstrate greater genetic overlap between neurological and psychiatric disorders than previously recognized, along with diverse neurobiological associations....
rdcu.be
Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range Dependencies
Spiking Neural Networks (SNNs) have gained increasing attention for their ability to operate on low-power neuromorphic hardware, offering a pathway toward energy-efficient large language models (LLMs)...
biorxiv.org
✨Hello folks!✨ We're back in your feed with an amazing paper spotlight by @kirahoeffler.bsky.social & colleagues📰🔦 "Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches" 🔗http://bit.ly/49syndi Read our overview below! 🧵1/6
Hey bsky-ers! New preprint from the lab on #psilocybin & social behaviour in #female mice in contexts relevant to eating disorders (food restriction, exercise & combo of) by PhD student Sheida 💙🦋
bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 10mo agoPsilocybin exerts differential effects on social behaviour and inflammation in mice in contexts of activity-based anorexia (ABA) https://www.biorxiv.org/content/10.1101/2025.10.14.682467v1
Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia
Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)
Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).
A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible! www.sciencedirect.com/science/arti...
GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex
Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…
sciencedirect.com
Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.
Incredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...
Toward a Genetic Signature of Resistance to Activity‐Based Anorexia in Striatal Projecting Cortical Neurons
Objective Converging evidence from neuroimaging studies and genome-wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology o...
onlinelibrary.wiley.com
How do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social
Stacey Kigar@staceykigar.bsky.social · 11mo ago‼️ New manuscript alert ‼️ I’m thrilled to share this work examining chronic stress-related “depression” and immune cells at the blood brain barrier: www.nature.com/articles/s41...
Understanding why antidepressants don't always work 🧠🛡️ New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression. 📖https://bit.ly/469cXyI
New updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
