Dr Xin Hui Chan 🕊️
@drxhschan.bsky.social
#Infection #GlobalHealth #Equity #Leadership • Consultant Physician 🦟🧫🦠🍄🪱💊💉• call me ‘Sin Hway’• she/her • views my own • reposts ≠ endorsements
Chris Whitty: Doctors must be trained in managing risk in patient care, CMO says. The BMJ and @acmedsci.bsky.social inaugural joint annual lecture given by Prof. Whitty covered risk, uncertainty, and medical decision-making. Watch the full lecture now: https://bit.ly/4AxqLBq
Congratulations, SOLARIO team @ouhospitals.bsky.social! 🦴🧫💊
NEJM.org@nejm.org · 2mo agoIn a randomized trial involving adults who received local antibiotics during surgery for orthopedic infection, a short duration of systemic antibiotics was noninferior to a long duration regarding treatment failure at 12 months. Full SOLARIO trial results: https://nej.md/4dgrqwY
Thank you @onisillos.bsky.social @lancetmicrobe.bsky.social for featuring our series on @who.int Target Product Profiles for Treatments for Dengue 💊
The Lancet Microbe@lancetmicrobe.bsky.social · 2mo agoNew series WHO Target Product Profiles for Treatments for Dengue: Accelerating Clinical Development for Global Health paper 1 Accelerating the clinical development of treatments for #dengue: WHO dengue therapeutics landscape analysis and target product profiles www.thelancet.com/journals/lan...
Lancet Microbe: Accelerating the clinical development of treatments for dengue: WHO dengue therapeutics landscape analysis and target product profiles Xin Hui S Chan, DPhil et al @lancetmicrobe.bsky.social bit.ly/4gxHAnU
🌏On World Dengue Day 2026, delighted to share @who.int’s TPPs to support the equitable clinical development, evaluation, and deployment of treatments for dengue for all age groups ahead of pivotal phase 3 trials 💊 #equity #access www.who.int/publications...
Target product profiles for treatments for dengue
The increasing global burden and geographic expansion of dengue, coupled with the absence of specific antiviral treatments, underscores the urgent need for safe, effective and accessible therapeutics ...
who.int
Ebola and hantavirus outbreaks prove why the world must urgently agree a deal to prevent pandemics www.politico.eu/article/ebol...
Ebola crisis exposes ‘preventable’ pandemic risk, say leaders
Ongoing outbreaks demonstrate the urgent need for a global pandemic deal, leaders say.
politico.eu
Many thanks to the UK HLH network and MDT at UCLH for your support on this complex case of HLH in a patient with HIV and Still's disease @OUHospitals Pleased our UK-wide learning is now available as a citable resource. Do reach out for further information www.thelancet.com/journals/lan...
Baricitinib and ruxolitinib use through the UK HLH Network
Haemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory state caused by pathological immune activation. HLH can be due to a primary genetic defect, but most adults and adolescents (age...
thelancet.com
The physician and pharmacologist died on February 1st, aged 74
Nick White was a hero of mankind’s oldest war
The physician and pharmacologist died on February 1st, aged 74
econ.st
Congratulations and well done, Tom Whitehead, on this excellent case report. Fantastic cross-departmental collaboration @ouhospitals.bsky.social to care for this patient & share his journey. Thank you also to colleagues at @escmid.bsky.social Global 2025 for input. link.springer.com/article/10.1...
It never rains but pours: disseminated nocardiosis in a renal transplant patient from Nigeria – a case report - BMC Infectious Diseases
BMC Infectious Diseases - Nocardiosis is a rare opportunistic infection with high mortality and a tendency to relapse. The causative Nocardia spp. are filamentous Gram-positive aerobic bacteria....
link.springer.com
Happy International Day of Women and Girls in Science 👩⚕️ 👩🔬 💊 🧪 🦠 🦟 💉 ⚕️ 🔬 🏥 🤝 🕊️
ESCMID@escmid.bsky.social · 9mo agoOn International Day of Women and Girls in Science, we empower women to take on leadership roles in the field of infection, creating strong role models to inspire the next generation. Read more: https://www.escmid.org/about-us/the-society/society-news/empowering-women-in-science/ #WomenInScience
🧫 Thank you, @escmid.bsky.social, for the kind sponsorship to attend one of your 2025 leadership courses. 💡What an enriching and eye-/heart-opening experience. Love the photo of us practising strategic crisis management!
ESCMID@escmid.bsky.social · 12mo agoThat's a wrap on our leadership courses for 2025! Participants described their experience as “extremely useful!” and enjoyed the practical exercises. 🚀 Sign up for our leadership mailing list to ensure you're the first to know about our courses in 2026! https://ow.ly/mlwU50Xxypq #IDSky #clinmicro
Rebalancing viral and immune damage versus repair prevents death from lethal influenza infection www.science.org/doi/10.1126/... @science.org @niaidnews.bsky.social
💊 Exciting news for dengue therapeutics 👏 Congratulations, Anna Durbin and colleagues! www.nejm.org/doi/full/10....
Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model | NEJM
Approximately half the worldwide population is at risk for dengue. No antiviral prophylaxis or treatment options are available. In a phase 2a, double-blind, randomized trial, we assigned healthy ad...
nejm.org
Not all medicines are equal ⏱️ Some need to be taken at a certain time 🍽️ Some need to be taken with food 🍂 Some may interact with herbal remedies #MedSafetyWeek
New Review: Kyasanur Forest disease: an emerging arboviral threat www.thelancet.com/journals/lan...
Kyasanur Forest disease: an emerging arboviral threat
Kyasanur Forest disease is a neglected tick-borne viral haemorrhagic fever endemic to India's Western Ghats, caused by the Kyasanur Forest disease virus, a flavivirus transmitted by Haemaphysalis spin...
thelancet.com
Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.thelancet.com/journals/lan...
Climate change and tuberculosis: an analytical framework
Climate change is likely to exacerbate a range of determinants that drive tuberculosis, the world's leading cause of death from a single infectious agent. However, tuberculosis is often neglected in w...
thelancet.com
SO excited to see this work come out, led by the incredible Laura Marks: doi.org/10.1093/ofid...
Infectious Diseases in People Who Use Drugs Introduction
Over the past 2 decades, there has been an unprecedented increase in infectious diseases among individuals with substance use disorders (SUDs). These inclu
doi.org
New Review Core outcome measurement set for clinical trials in dengue: an international Delphi consensus study (DEN-CORE) www.thelancet.com/journals/lan...
Core outcome measurement set for clinical trials in dengue: an international Delphi consensus study (DEN-CORE)
Dengue, caused by any one of four distinct virus serotypes, is the most rapidly spreading mosquito-borne viral disease worldwide. It is a primary arboviral infection with increasing global incidence, ...
thelancet.com
"Usutu, which mainly infects birds, was first detected in London blackbirds in 2020 and has been found in birds or mosquitoes every year since, making it now endemic to the UK … Usutu often establishes first, with West Nile following as temperatures rise." theconversation.com/first-eviden...
First evidence in the UK of breeding aegypti mosquito – the main spreader of dengue, chikungunya and Zika
The first discovery of Aedes aegypti eggs in the UK shows how climate change and global travel are helping mosquitoes that spread dengue and Zika expand northwards.
theconversation.com
Pleased to see this out today in @lancetmicrobe.bsky.social www.sciencedirect.com/science/arti.... We estimate the independent effects of AMR genes on MIC at a drug-bug level and challenge the idea that resistance is a binary phenomenon.
Estimating the association of antimicrobial resistance genes with minimum inhibitory concentration in Escherichia coli: an observational study
Surveillance and prediction of antibiotic resistance in Escherichia coli relies on curated databases of genes and mutations. We aimed to quantify the …
sciencedirect.com
📢 "Invasive #mosquito surveillance in the #UnitedKingdom 2020 to 2024: First detection of #Aedes aegypti eggs in the UK and further detection of Aedes albopictus 🦟" by Colin Johnston et al. @ukhsa.bsky.social published in @plosglobalpublichealth.org journals.plos.org/globalpublic...
The invasive form of Ae. #aegypti mosquito evolved within the Americas, after arriving from Africa ~320 ya. Our most recent paper is out @science.org. Years of work with collaborators all around led by J. Crawford! Great resource for the Vector Research community!. www.science.org/content/arti...
How the yellow fever mosquito conquered the world
Aedes aegypti further adapted to life around humans when it arrived in the Americas, study of hundreds of mosquito genomes reveals
science.org
🦟" #France 🇫🇷 reports 1st local #dengue case, #chikungunya cases rise to 25" via @outbreaknewstoday.substack.com.web.brid.gy open.substack.com/pub/outbreak...
France reports 1st local dengue case, chikungunya cases rise to 25
According to French health authorities, a total of 10 new episodes of arboviral transmission transmitted by Aedes albopictus have been identified in mainland France: 9 episodes of chikungunya and 1 of...
open.substack.com
Great news for paediatric access to artemether-lumefantrine 🦟 💊 www.reuters.com/business/hea...
Novartis gets approval for first malaria drug for babies and children
Novartis on Tuesday said it had received approval in Switzerland for Coartem Baby, which it said was the first drug to treat malaria in babies and young children.
reuters.com
"Regardless of its justification—be it financial, convenience, or otherwise—a lone actor should not be allowed to unilaterally undermine the ethical provision of healthcare in the United States." academic.oup.com/cid/advance-...
Pulling the Drug Out From Underneath: Ethical Considerations in the Discontinuation of the Antimalarial Quinidine
Abstract. In 2017, the pharmaceutical company Eli Lilly announced it would stop manufacturing quinidine, the only Food and Drug Administration–approved tre
academic.oup.com
📆 15 June is World Dengue Day 🦟 Dengue is the most important vector-borne viral infection in humans, with record cases in 2024, but no licensed treatments 💊 @who.int are seeking feedback on target product profiles for dengue treatments 🗣️ Do share widely - thank you! www.who.int/news-room/ar...
Call for public consultation ̶ Target Product Profiles for Treatments for Dengue Fever
The World Health Organization (WHO) is seeking feedback on the TPP from experts in the industry, product developers, the scientific community, NTD programme personnel and clinicians currently involved...
who.int
Applications for the Barnett Christie Lecture at FIS 2025 are now open! Each year the BIA invites applications to deliver this highly prestigious lecture at the conference of the Federation of Infection Societies. Find out more and apply 👉 champ.ly/2kIjacU-
Given #YellowFever vaccination seems to have become topical, this article might be of interest. www.thelancet.com/journals/lan...
Yellow fever breakthrough infections after yellow fever vaccination: a systematic review and meta-analysis
Yellow fever breakthrough infections documented in literature are rare, and not necessarily more common 10 years or more after primary yellow fever vaccination. This finding suggests that a single dos...
thelancet.com
Read our June issue! Featuring effectiveness of RSV vaccination in older people in the US, malaria prevention in children with sickle-cell anaemia, and testing new serological tools for arboviral infections www.thelancet.com/journals/lan...
