This Cell Feeds, Grows and Reproduces. And It’s Manmade.

From chemical building blocks, scientists have created synthetic cells that have most of the hallmarks of life.

nytimes.com

Archaeal and eukaryotic MCM rings sequentially melt DNA for replication initiation - Nature Communications

To prepare for DNA replication, a short region of DNA base-pairs must be broken, termed melting, allowing a helicase to gain a foothold on an isolated DNA strand. Here, authors use single-particle cry...

doi.org

Melanie Mitchell: What We Get Wrong About AI

Melanie Mitchell probes the jagged landscape of AI and its uncertain future.

yalereview.org

Tout ce que l’IA a déjà révolutionné dans la recherche scientifique

Réflexion, planification stratégique, analyse des données, génération d’hypothèses de travail, enseignement universitaire… La montée en puissance des outils d’intelligence artificielle, en particulier...

lemonde.fr

On Leading People Who Don’t Want to Be Led (opinion)

Many faculty say this is not the job they signed up for. They need leaders who see this and who are looking out for them.

insidehighered.com

Premature transcription termination modulates stochastic gene expression in bacteria

Bacteria tune transcription bursts through early termination, enabling switch-like and gradual adaptation to nutrients.

science.org

Why noise may be the key to understanding cell group patterns

All of biology is transient. Over time, a population of identical cells can change so that some subgroups exhibit different behaviors — everything from varying sizes to the expression of certain prote...

santafe.edu

Reconstitution of Archaeal Membrane Lipid Biosynthesis in Bacterial and Eukaryotic Hosts

The membrane lipids of archaea differ from those of bacteria and eukarya in backbone stereochemical configuration, chemical linkage type, and hydrophobic chain structure, a fundamental dichotomy term...

doi.org

Archaeal family B DNA polymerase facilitates lagging strand DNA replication in the Thermococcales

Abstract. Replicative DNA synthesis is distributed among several DNA polymerases (DNAPs) in both Bacteria and Eukarya. The division of synthesis permits sp

academic.oup.com

A disrupted microbial network and an ecological shift towards anaerobes in NTM-infected cystic fibrosis patients

Nontuberculous mycobacteria (NTM) are increasingly recognized as opportunistic pathogens in people with cystic fibrosis (pwCF), but the ecological fac…

sciencedirect.com

Microfluidic device tracks cell 'squishiness' faster and more reliably than standard methods

Researchers from Brown University and their collaborators have developed a new way to measure the properties of cells—an important development, they say, because accurate measurements of changes in cell elasticity can be used to better understand diseases, diagnose patient symptoms and provide more accurate prognoses.

phys.org

biorxiv.org

Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides | PNAS

Oxidative stress induces damage to DNA, RNA, and nucleotide pools. Unlike well-studied DNA damage, the formation of RNA damage and the impact of an...

pnas.org

Science | AAAS

science.org

A path towards AI-scale, interoperable biological data

Biology is at the precipice of a new era where AI accelerates and amplifies the ability to study how cells operate, organize, and work as systems, revealing why disease happens and how to correct it. ...

arxiv.org

Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology

Diversity-generating retroelements are engineered for directed evolution in E.coli.

nature.com

BBC Radio 4 - In Our Time, Archaea

How a discovery in the 1970s changed the theory of the origin of complex life on earth.

bbc.co.uk

Deep representation learning of protein-protein interaction networks for enhanced pattern discovery

A strategy preserves complex networks in lower dimensions with discriminative node representation, enhancing PPI network analysis.

science.org

The root of pan-adaptationism?

There’s been a fair bit of recent discussion about why most biologists are (uncritically) adaptationists. I don’t dispute this but think it’s worth reconsidering why. Some have argued that this is bec...

micropopbio.org

biorxiv.org

Asgard archaea: have we found our microbial ancestors? - The EMBO Journal

The discovery of Asgard archaea about a decade ago has greatly reshaped our understanding of archaeal evolution and the origin of eukaryotes. Asgards are currently thought to be the closest prokaryoti...

link.springer.com

Parallel but distinct adaptive routes in the budding and fission yeasts after 10,000 generations of experimental evolution - Nature Ecology & Evolution

Experimental evolution of fission yeast (Schizosaccharomyces pombe) in the same environment as a previous experiment with budding yeast (Saccharomyces cerevisiae) reveals parallel evolution but distin...

nature.com

New AI model could cut the costs of developing protein drugs

MIT researchers used a large language model to optimize the genetic sequences of proteins manufactured by yeast, making production more efficient.

lifescience.net