This September, I will join the @flatironinstitute.org Center for Computational Neuroscience as a Group Leader, where I will launch the High-Dimensional Dynamics & Computation Group. Information for postdocs and grad students is forthcoming. I am grateful to my mentors who made this possible!

Go David!!! Cannot recommend more highly!!! My biggest regret is not paying more attention in math classes if only for the opportunity to work with you!

David G. Clark@david-g-clark.bsky.social · 5d ago

This September, I will join the @flatironinstitute.org Center for Computational Neuroscience as a Group Leader, where I will launch the High-Dimensional Dynamics & Computation Group. Information for postdocs and grad students is forthcoming. I am grateful to my mentors who made this possible!

How does the brain represent the value of knowledge? In our paper--out now at Nature Neuroscience--we identify a representation of intrinsic information value within neural population structures in the orbitofrontal cortex in mice. www.nature.com/articles/s41593-026-02377-y #neuroskyence 🧠🧪 (1/8)

Representations of the intrinsic value of information in mouse orbitofrontal cortex - Nature Neuroscience

Mice are motivated to seek information of no extrinsic value. Recording neural activity in orbitofrontal cortex reveals a representation of the value of information that is distinct from the value of ...

nature.com

📣New paper! How does the sleeping brain help us to integrate new experiences while managing memories from the past? For his PhD work, @sabbaspoor.bsky.social recorded hippocampal ensembles in freely moving monkeys and found something unexpected. 🧵1/n www.nature.com/articles/s41... 🧪🧠📈👩‍🔬#OpenAccess

Experience reorganizes content-specific memory traces in macaques - Nature Neuroscience

In macaques, old memories, relative to new ones, are supported by more stable and interconnected cell assemblies. New-biased and old-biased assemblies reactivate during overnight sleep and can sometim...

nature.com

How do you "see" with electric eyes? How does collective behavior emerge from individual interactions? Nocturnal weakly electric fish evolved to do this, but studying naturalistic social behavior is very hard. Our solution? Virtual 'fish' 🤖🐟⚡ 📄 arxiv.org/abs/2511.08436

If an action results in error, each neuron requires an individualized teaching signal that guides change in its output. This is the credit assignment problem of learning. Are there neurons in the brain that can compute such a sophisticated teaching signal? Yes. www.biorxiv.org/content/10.6...

Climbing fibers encode the gradient of a loss function for the cerebellum

Neurons in the brain are often many synapses away from motoneurons, yet if a movement results in error, each distant neuron needs a teacher that considers its specific contribution to production of th...

biorxiv.org

Board passed the resolution.

Vinny Costa@vincentcostaphd.bsky.social · 2w ago

The President of OHSU Shereef Elnahal and the OHSU Board of Directors will be voting to effectively gut research and shutdown the Oregon National Primate Research Center on 7/27/2027. Public comments can be submitted here until 3PM EST today. savescienceoregon.org/contact

Dragging Science’s EIC for using an LLM as a search engine just tells me you’ve never heard of PageRank.

Holden Thorp@holdenthorp.bsky.social · 3w ago

Hi, this is Holden emerging from my Bluesky hiatus to tell everyone that when checking the links in the piece, I used ChatGPT as my search engine (does anyone use Google anymore?). The piece was written by me and edited by humans. So all the links were checked by me and again by our copyeditors.

Every day, our brains arbitrate between competing memories and motivations. This ability allows us to flexibly adapt our behavior as the world around us changes. But how does the brain actually do it? Our new study sheds light on this! www.cell.com/current-biol...

The prelimbic cortex arbitrates memory-guided conflict resolution

Caban-Murillo et al. show that, during approach-avoidance conflict, prelimbic cortex ensembles are recruited to represent reward and punishment through distinct network patterns. Both ensembles are ne...

cell.com

Out today on @nature.com! Connecting neural specialization, population geometry, and their functional implications across the cortical hierarchy. So grateful for this beautiful and fun collaboration with @shuqiw.bsky.social, S Muscinelli, L Paninski, and @stefanofusi.bsky.social!

Rarely categorical, highly separable representations along the cortical hierarchy - Nature

Cortical circuits prioritize diversity over categorical structure, supporting a computational regime geared towards high-dimensional, highly separable neural representations.

nature.com

Come find us at #FENS2026 in Barcelona with @melisa-mc.bsky.social , Teresa and Violeta. Three posters, three views of hippocampal dynamics, from brain excitability to inhibitory circuits and ripple waveforms. 🧠 @fens.org @cncajal-csic.bsky.social

Adding to all the takes on this, something that is missed and why I don't think AI will progress beyond research assistant in neuroscience is so much of the work is embodied. Not just in that "an LLM doesn't have a body" but so much of the knowledge is only gained through embodiment.

Mark D Humphries@markdhumphries.bsky.social · last mo.

At Cosyne, Chris Olah from Anthropic told us that neuroscientists had “3-4 years left to make a contribution” Why was not clear. Perhaps he was hinting at the below graph accompanying today’s Claude Science launch. Apparently we’ll all be obsolete soon.

My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735

Very excited for our new paper, now out in @cellcellpress.bsky.social! /🧵 The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms are not clear /1 authors.elsevier.com/sd/article/S...

Arc mediates intercellular tau transmission via extracellular vesicles

Tau pathology spreads cell to cell, but the mechanisms of intercellular tau transmission remain unclear. We find that the neuronal gene Arc is critica…

authors.elsevier.com

If you're interested in doing theory work in New York, I will be recruiting for multiple graduate student and postdoctoral positions; please get in touch if interested (at jzavatoneveth@rockefeller.edu), and stay tuned for an official posting.

Tremendously excited to announce that I will be joining @rockefeller.edu as an Assistant Professor and Head of Lab starting in January 2027! My group will be broadly focused on theoretical neuroscience, and mathematical problems in neural computation in the large.

My friend's NSF CAREER received the highest possible score (Excellent, Excellent, Excellent: High Priority) and it was rejected today. This would have been my friend's first extramural award, 5 years after starting their lab, exactly when grant $ is make or break for an Assistant Professor's career.

Jeffrey Mervis@policyhound.bsky.social · last mo.

Been wondering why NSF isn't spending most of its FY26 appropriation? A $1.5B tech initiative may be the reason. And big cuts to hundreds of research programs could be just the beginning of the bad news. www.science.org/content/arti...

1/ Complex behavior demands the sequential coordination of hundreds of muscle groups. The body is mapped topographically in the brain, but does neural activity actually propagate across these maps to organize sequential action? Our new paper in Science: doi.org/10.1126/scie... 🧵

The Neural Control & Computation Lab is recruiting a Postdoctoral Fellow to investigate the neural basis of learning, flexible neural computation, and skilled movement control using large-scale electrophysiology from single-neuron populations in non-human primates 🧠🐒 www.ncclab.ca/join-the-lab

The Giardino Lab at Stanford is hiring a full-time post-bacc Research Assistant! If you know someone who is passionate about research and want to work at the intersection of stress, addiction, and sleep/wake neurobiology, have them apply here. careersearch.stanford.edu/jobs/life-sc...

NIH announces the creation of the Office of Research Innovation, Validation, and Application (ORIVA) to reduce use of animals in research. dpcpsi.nih.gov/oriva

New from the lab: Fred Stoll & Neelima Valluru looked at how neural activity in frontal ctx tracks deliberative decision making. In a trial they found that activity flips between the options. When this flip happens it reshapes the neural geometry of option attributes. www.biorxiv.org/content/10.6...

Dynamic geometry remapping of neural activity within frontal and subcortical areas during decision-making

Decision-making involves dynamic evaluation of competing options. Recording 16,495 neurons across nine frontal and subcortical areas in macaques revealed brain-wide fluctuations between encoding the a...

biorxiv.org

Applications are now open for our fall science reporting internship! This is an excellent opportunity for a beginning science journalist to report and write about the fast-moving field of neuroscience. Apply now: simonsfoundation.wd1.myworkdayjobs.com/simonsfounda... #neuroskyence

Many of the scientific questions we're interested in tackling require studying learning over long periods of time across the brain. This is challenging – which is why we're excited to say we've been developing a system for chronic wireless recording using long Neuropixels probes in macaque monkeys.

Neuroscientist here, who has talked about the US losing science ground to other countries: The biggest problem for generating future cures for brain diseases is the ongoing utter destruction of US basic neuroscience. It’s not about regulation.

Semafor@semafor.com · 2mo ago

China’s beating the US in neuroscience: “There is a very real possibility that without significant regulatory reform, if you’re a wealthy American, in 10 years, the only place you’ll be able to get your state-of-the-art cancer care is in Shanghai,” said Max Hodak, former president of Neuralink.

🚨 New preprint from the lab! 🚨 We introduce BiXformer, a bidirectional cross-attention transformer for disentangling inter-regional neural dynamics. Recordings from multiple regions superimpose feedforward & feedback signals 🔁, offset in time, making it difficult to tease these signals apart. 🧠 🔁

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2mo ago

BiXformer: A Bidirectional Cross Attention Transformer for Disentangling Inter-Regional Neural Dynamics https://www.biorxiv.org/content/10.64898/2026.06.05.730511v1

Agentic coding is genuinely useful now, and there are some impressive reports of AI agents doing science. But how well and how reliably can they handle tasks scientists actually want to hand off, ones that bottleneck progress? How do we even measure that?? New paper🧵 arxiv.org/abs/2606.07718 1/10

A case study of evaluating AI agents on a neuroscience data-to-discovery pipeline

Agentic AI tools offer a promising path to automating software development bottlenecks in scientific research pipelines, particularly for stages that take domain experts days to months to build, where...

arxiv.org

NEW PAPER. Why do larger networks train better? "Because they contain more candidate *sub*networks that can learn the task" → lottery tickets This popular explanation uses an appealing but misleading metaphor🧵 We propose an intuitive alternative grounded in theory: escape dimensions

I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇

My PhD work on how lateral septum cells and circuits process threat cues to guide defensive actions is now online at @nature.com rdcu.be/fjNgT w/ @gordfishell.bsky.social and others

Feature-specific threat coding in lateral septum guides defensive action - Nature

The populations of CRHR2-expressing neurons in the lateral septum of mice involved in threat-related behaviour in response to environmental challenges are defined.

nature.com