Uh, so.... I vibe-coded an entire replacement for ChemDraw that works with AI agents. It was about 8 months of work, and the goal is just open-source-stop-dependeing-on-american-paywalled-software. It has a plugin API, it comes with claude/codex skill docs check it out: jgassens.github.io/ChemDraft/

The last work of Stefano Nicolai, Daphne Lucidarme and Matthew Wodrich on the formal cycloaddition of azadienes and bicyclobutanes is now accepted in Chemical Science! doi.org/10.1039/D6SC...

The work of @helsoleav.bsky.social @duncanbrownsey.bsky.social and Hugo Senelle, on the alcohol-directed carboamination of enynes is now published in Angewandte Chemie ! doi.org/10.1002/anie...

Alcohol‐Directed Carboamination of Conjugated Enynes

The first general three-component intermolecular Pd-catalyzed carboamination of conjugated enynes enables the coupling of anilines and aryl triflates to produce functionalized allenic amines, utilizi...

doi.org

The work of Josh, Tobias and Matthew on the synthesis of CF3-cycloproprenes using hypervalent iodine reagents and Cu(III) complexes is now published in Org. Lett. doi.org/10.1021/acs....

Accessing CF3-Cyclopropenes ─ A Platform for the Synthesis of Trifluoromethylated Building Blocks

Cyclopropenes are the smallest unsaturated carbocycles. They possess exceptionally high ring strain, resulting in unique reactivity, enabling C═C bond functionalization and ring-opening transformation...

doi.org

Very happy to share that our Pd-catalyzed method for the functionalization of cyclopropenes is now available to read in @chemicalscience.rsc.org !

Waser Group@lcsolab.bsky.social · 10mo ago

Have a look at the last work of @duncanbrownsey.bsky.social and Alexandre Schoepfer combining small rings and Pd catalysis for the stereoselective synthesis of spirocyclic cyclopropane-oxazolines just published @chemicalscience.rsc.org ! pubs.rsc.org/en/Content/A...

We just achieved the first site-selective cysteine functionalization with EBX reagents! @jacs.acspublications.org pubs.acs.org/doi/10.1021/...

Ligand-Directed Site-Selective Cysteine Bioconjugation of the KELCH Domain of KEAP1 with Hypervalent Iodine Reagents

Affinity-driven reactions have allowed chemists to perform site-selective modifications of native proteins. By combining the high cysteine chemoselectivity of hypervalent iodine-based ethynylbenziodox...

pubs.acs.org

The preprint of the work of Josh Wu, Tobias Milzarek and Matthew Wodrich on the trifluoromethylation of Cyclopropenylbenziodoxoles is now available at ChemRxiv. This method gives access to unique fluorinated building blocks. chemrxiv.org/engage/chemr...

From now on until end of September we consider applications to @lcsolab.bsky.social for a regular PhD position starting earliest in September 2026! For general information, see: www.epfl.ch/labs/lcso/gr... For details on the application process, see: www.epfl.ch/labs/lcso/wp...