Come and join my group at @oxfordchemistry.bsky.social! We have an opening for a postdoc position in photopharmacology. Prior experience with photoswitches and photopharmacology essential. Deadline 27th April. For more details see my.corehr.com/pls/uoxrecru... #Chemsky

Job Details

my.corehr.com

We're hiring a Postdoctoral Fellow! How does Mycobacterium tuberculosis survive drug treatment? You'll use molecular genetics and single-cell approaches to investigate how gene expression variability drives drug-tolerant subpopulations. Full details and application instructions below.

The latest AI/ML tools for co-folding proteins around small molecule ligands can produce impressive results. Until you start looking at them closely.

AI-Predicting Compound Affinity. We Aren't There Yet.

science.org

Very excited to share our recently published work on NTM and their response to acid stress! As my first paper, I’m especially grateful for the support and guidance from @luizcarvalholab.bsky.social , Rachel and @maxgg.bsky.social . More to come!

Max Gutierrez@maxgg.bsky.social · 5mo ago

Very happy to see this out! Great work by @lockwop.bsky.social @crick.ac.uk and first paper on NTMs from the lab! Parise made a set of 12 fluorescently labelled NTMs covering environmental and opportunistic mycobacteria... onlinelibrary.wiley.com/doi/10.1111/...

Are you interested in being the first biologist in our new team? Come join our small but growing group. Deadline for applications is 3rd March. #Tuberculosis 🧪🦠 #TBDrugDiscovery

Technical Programme Manager | Liverpool School of Tropical Medicine

Technical Project ManagerLocation: LiverpoolContract: Fixed-term contract until March 2028Salary: £47,389 - £59,967The Parish Lab at the Liverpool School of Tropical Medicine focuses on antimicrobial ...

app.vacancy-filler.co.uk

I am happy to share our recent publication in @nature.com on a mucosal immunization strategy that clears C. difficile colonization in mice. Congratulations to Audrey Thomas, lead author on the work. www.nature.com/articles/s41...

📢 4-year PhD position in my lab at @crick.ac.uk Using active learning & chemical genomics to find new antibiotics with new targets in pathogenic bacteria. Looking for: chemistry / chem bio / comp bio / micro backgrounds with coding interest. Deadline 17 March. www.crick.ac.uk/careers-stud...

I’m looking forward to this incredible opportunity to advance the science of antibiotic discovery with the Gr-ADI consortium.

The Francis Crick Institute@crick.ac.uk · 6mo ago

A research team from the Crick led by @eachan.scbir.org has joined a three-year, international collaboration to tackle antibiotic resistant bacteria. The partnership is championed by the Gates Foundation, @wellcometrust.bsky.social and @novo-nordisk.bsky.social. www.crick.ac.uk/news/2026-02...

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...

Multiple protein structure alignment at scale with FoldMason

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

science.org

www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!

Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com

PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com

findaphd.com

We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing. It’s not a toxin. It’s metabolism. The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place. doi.org/10.1126/sciadv.aeb5297

Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing

E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.

doi.org

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

Collaboration of AI and wet experiments with high thoughput technology is the one of solution IMHO.

We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications

Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...

nature.com

"Across the highest adult performance, peak performance is negatively correlated with early performance" Is uite literally what you'd see if coliderbias:

@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs www.biorxiv.org/content/10.6...

Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...

Recent discoveries on the acquisition of the highest levels of human performance

Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...

science.org

Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb

How phototherapy could reverse antibiotic resistance

Lars Stevens-Cullinane works in a dark room. But he's not processing negatives and printing photographs on light-sensitive paper; he's testing whether brief flashes of light can make drug-resistant bacteria sensitive to antibiotics.

phys.org

📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...

🚨Deadline for our Senior Scientist applications is next week. If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!

Eachan Johnson@eachan.scbir.org · 10mo ago

📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections. If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below. www.linkedin.com/jobs/view/43...

Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research. Apply now to join us ➡️ www.crick.ac.uk/careers-stud...

Just a few weeks left to apply for our clinical PhD programme. We're looking for clinicians who are passionate about research to join the 3-year fully funded programme. Learn more and see what positions are available ⬇️ www.crick.ac.uk/careers-and-...

Doctoral clinical fellows

The Crick's clinical PhD programme.

crick.ac.uk

📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections. If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below. www.linkedin.com/jobs/view/43...

Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.

The Francis Crick Institute@crick.ac.uk · 10mo ago

We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...

We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad: idm.uct.ac.za/media/739223

Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!

Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com

The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all

Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.

statnews.com

🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...

Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery

Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...

chemrxiv.org

📢 PhD Opportunity @crick.ac.uk Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants. We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species. November deadlines. More details ⬇️🧵

PhD students

Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.

crick.ac.uk

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology

By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...

nature.com