BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
Luiz Pedro Carvalho, PhD
@luizcarvalholab.bsky.social
Professor of Chemistry @UFScripps Interested in enzymology, bacterial metabolism, chem bio, mycobacteria, antibiotic discovery and antibiotic resistance. Former group leader at NIMR and The Crick.
Join us and become my colleague! The School of Biological Sciences is opening the search for an Assistant Professor in the field of Host-Microbe Interactions with the targeted start date of Fall 2027. Please reach out to me with any questions you have: jobsearch.illinoisstate.edu/jobs/assista...
ASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY) - Normal, Illinois, Illinois, United States
Title: ASSISTANT PROFESSOR IN HOST-MICROBE INTERACTIONS (IMMUNOLOGY, MICROBIOLOGY)Employee Classification: Asst ProfessorDivision Name: Academic AffairsCollege/Unit: College of Arts and SciencesDepart...
jobsearch.illinoisstate.edu
Structural and Mechanistic Insights into 4′-Dehydrogenation Catalyzed by AprD5 in Apramycin Biosynthesis
Structural and Mechanistic Insights into 4′-Dehydrogenation Catalyzed by AprD5 in Apramycin Biosynthesis
Abstract. AprD5 is a member of the NAD+-dependent short-chain dehydrogenase/reductase (SDR) superfamily. It participates in the apramycin biosynthetic path
pubs.acs.org
A methanogen hydrolase reveals the structure of archaeal peptidoglycan www.nature.com/articles/s41... #jcampubs
A methanogen hydrolase reveals the structure of archaeal peptidoglycan - Nature
ArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl hydrolase specific for cleaving the cell wall of methanogens, reveali...
nature.com
"Philosophy of Biology: The power of theory in the life sciences" elifesciences.org/articles/112... @zdblount.bsky.social shared this thought-provoking paper with the lab group.
Philosophy of Biology: The power of theory in the life sciences
Theory can help address cell and molecular biology’s major challenges, particularly those arising from large omics datasets.
elifesciences.org
Less than 2 weeks to apply! If you are looking for early career fellowship sponsorship, consider @dunnschool.bsky.social to launch your independent career Great science, great support and, of course, lovely colleagues... www.path.ox.ac.uk/work-with-us...
Group Leader Career Development Fellowships - Dunn School
Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?
path.ox.ac.uk
🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: https://apply.interfolio.com/190640
Please have a look at our review on a very interesting and underappreciated group of proteins... Getting a grip on StAR-related lipid-transfer (START) domain proteins in bacteria academic.oup.com/femsre/artic...
Getting a grip on StAR-related lipid-transfer (START) domain proteins in bacteria
Bacterial START domain proteins have a conserved helix-grip fold, but diverge from mammalian lipid transporters by utilizing a more versatile array of proc
academic.oup.com
Check this out: desiccation imposed during aerosol transmission might be an unpredicted source of DNA damage and hence, bacterial evolution. www.nature.com/articles/s41...
Desiccation promotes DNA damage and rifampin resistance in Mycobacterium tuberculosis - Nature Microbiology
Analysis of desiccation stress responses in Mycobacterium tuberculosis reveals increased oxidative stress and DNA damage, leading to upregulation of the transcription-coupled repair factor, Mfd, which...
nature.com
Wow. In a previously unknown toxin-antitoxin system (RelS-RelI) the RelS toxin halts bacterial growth by cleaving 16S rRNA at a unique site in the anti-Shine-Dalgarno region. Beautiful use of comparative genomics at the species level, powerful. @oneyrolles.bsky.social Makarova & Genevaux.
Come be my colleague! We are hiring a structural biologist. I have thoroughly enjoyed starting my career here and both department(s) are full of exceptional scientists. apol-recruit.ucsd.edu/JPF04589
Assistant Professor in Structural Biochemistry
University of California, San Diego is hiring. Apply now!
apol-recruit.ucsd.edu
Junior faculty position in Basic Sciences @fredhutch.org! Please repost!
Fred Hutch@fredhutch.org · 2mo ago🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: https://apply.interfolio.com/190640
Exciting!! Not all protein functions are what we think. We found a protein that looks like a well-known enzyme but does a different job entirely. This discovery reveals hidden metabolic diversity in Mycobacterium and may have implications for malaria parasites and related organisms. Links below:
Bronsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants www.nature.com/articles/s41...
Brønsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants - Nature Chemical Biology
Through chemical complementation, Brønsted-basic small molecules rescue the loss of the catalytic glutamine side chain in KRAS-Q61X mutants, accelerating GTP hydrolysis up to 20-fold.
nature.com
Are you an ecologist/evolutionary biologist looking for an ongoing academic position? Monash University’s School of Biological Sciences is hiring! Come join us in Melbourne, Australia! Details here: careers.pageuppeople.com/513/cw/en/jo...
Don't miss the ACS Infectious Diseases Early Career Award session on Monday, August 24 in Conference Center room S106a from 8-12 PM as part of #ACSFall2026!
Machine Learning for enzyme function discovery (truly)... take a look at this excellent work from Newman, Conway and colleagues. www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Structures of cannabinoid cyclase show that bacterial and plant cyclases use distinct mechanisms for cannabinoid synthesis, and variants are engineered with improved stereocontrol www.nature.com/articles/s41...
Structural and biochemical basis for cannabinoid cyclase activity in marine bacterial flavoenzymes - Nature Chemical Biology
Cannabinoid cyclases produce bioactive cannabinoids, but their mechanisms are poorly understood. Here the authors solve the substrate-bound structure of a cannabinoid cyclase, show that bacterial and ...
nature.com
Protein stability is determined by single-site bias rather than pairwise covariance www.nature.com/articles/s41...
Protein stability is determined by single-site bias rather than pairwise covariance - Nature Chemical Biology
Sequence biases at individual positions can be used to design more stable protein variants, while correlation between pairs of residues has also been shown to be important for specifying protein struc...
nature.com
Are you a postdoc interested in the mechanisms of disease? Do you have a great record and an exciting vision? Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships. Deadline 22nd of September...please share! www.path.ox.ac.uk/work-with-us...
Group Leader Career Development Fellowships - Dunn School
Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?
path.ox.ac.uk
Multiple very interesting papers coming online in Nature Microbiology, but I would like to call your attention to this one. Particularly important for the mycobacterium drug discovery community. @siegristpalmore.bsky.social and team, congratulations. www.nature.com/articles/s41...
Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning - Nature Microbiology
Screening 1,572 compounds for mycomembrane permeation plus cheminformatic and machine learning analyses reveals features associated with improved permeation in the pathogen Mycobacterium tuberculosis ...
nature.com
Out Now! Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils #MicroSky
Mobile genetic elements shape microbial diversity and functions in thawing permafrost soils
Nature Microbiology, Published online: 29 June 2026; doi:10.1038/s41564-026-02391-7An 8-year soil meta-omic time series shows how mobile genetic elements shape permafrost microbial diversity and impact a range of functions, including carbon and nutrient cycling.
go.nature.com
A 'megacluster' of genes found in a common soil bacterium can produce a range of antibiotics that can act against multi-drug-resistant bacteria go.nature.com/4aRR6ii
Antibiotic cocktail made by soil bacteria can kill superbugs
Nature - Four antibiotic compounds produced in Streptomyces bacteria attack multiple parts of an essential metabolic pathway.
go.nature.com
New #microsky#AMR Perspective paper with @penamiller.bsky.social rdcu.be/fqBJo ANTIBIOTIC RESISTANCE (IE MIC) AND TOLERANCE ARE NOT BACTERIAL TRAITS! Please read on if you want an explanation for this provocative claim.
Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
Nature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells
rdcu.be
Recruiting a postdoc to join my lab at @lshtm.bsky.social to work in an MRC porgramme grant funded project to dissect the gut colonziation by Klebsiella. In vivo and in vitro models, and new approaches to identify Klebsiella factors involved. jobs.lshtm.ac.uk/vacancy.aspx...
Job Opportunity at LSHTM: Research Fellow
The London School of Hygiene & Tropical Medicine (LSHTM) is one of the world’s leading public health universities. Our mission is to improve health and health equity in the UK and worldwide; working i...
jobs.lshtm.ac.uk
Our Dept of Microbiology & Immunology @Geisel School of Medicine @Dartmouth has an opening for an Assistant Professor. Looking for programs bridging multiple areas in Micro & Immuno. A great place to be! Programs: www.M2P2.org www.dartmouthbiofilm.org Job ad: apply.interfolio.com/187637
Discovering nickel enzymes within the aldo-keto reductase superfamily #chemsky
Discovering nickel enzymes within the aldo-keto reductase superfamily
Nature Chemistry, Published online: 19 June 2026; doi:10.1038/s41557-026-02185-8Few nickel enzymes have been discovered to date, limiting understanding of nickel-catalysed chemistry in nature. Now, a unique family of nickel pincer mononucleotide-utilizing enzymes has been identified through bioinformatics and characterized through biochemical and structural studies, expanding the known repertoire of nickel enzymes.
dlvr.it
PBCNet2.0 predicts relative affinity changes induced by ligand modifications for probe discovery and optimization and shows an emergent capability to predict affinity changes due to binding residue mutations, supporting drug resistance analysis www.nature.com/articles/s41...
Atomic-level protein–ligand recognition with PBCNet2.0 for probe discovery - Nature Chemical Biology
Protein–ligand binding affinity prediction is important for the development and optimization of molecular probes. PBCNet2.0 predicts relative affinity changes induced by ligand modifications (for exam...
nature.com