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European Association of Neuro-oncology, multidisciplinary society, Clinical Trials, Research, Education #EANO2026 #btsm #neurooncology #braintumor #cancer | www.eano.eu

🎗️Today is Glioblastoma Awareness Day 2026 - a day to raise awareness of #glioblastoma. At EANO, we are constantly committed to advancing research, improving diagnosis, fostering international collaboration, and supporting the development of more effective treatments to improve outcomes for patients.

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How to determine the extent of resection in meningiomas? Read our new manuscript on a comparison of Simpson grade vs. MRI across histomolecular subgroups! @eanoassociation.bsky.social @neuroonc.bsky.social doi.org/10.1227/neu....

Comparative Analysis of the Prognostic Value of Simpson... : Neurosurgery

tives. The aim of this study was to compare the prognostic performance of SG vs MRI-based EOR paradigms for predicting recurrence and survival across histomolecular subgroups. METHODS: International multicenter, retrospective cohort study included 475 meningiomas, resected between 1983 and 2024, which were classified by World Health Organization grade and molecular subgroups (DNA methylation, gene expression, and integrated grade). Area under the curve (AUC) was calculated for LFFR and overall survival (OS) from Cox models with a histomolecular subgroup and an EOR paradigm. Delta AUC (ΔAUC) compared EOR predictive performance within each subgroup, and log-rank comparisons of LFFR and OS were performed. RESULTS: MRI-defined gross total resection was associated with significantly longer LFFR and OS when compared with subtotal resection across most histomolecular subgroups. SG1-3 vs 4 distinguished differences in LFFR across several subgroups, but there were no consistent differences in outcomes when comparing degrees of dural treatment. Multivariable Cox including gene expression groups revealed that volumetric EOR (%) had a significantly higher AUC than SG (ΔAUC 0.07, P = .036) for 5-year OS; otherwise, there were no other differences between MRI-based or SG EOR paradigms for 5-year LFFR or OS. Additional significant differences for predicting 10-year LFFR all favored MRI-based EOR paradigms. CONCLUSION: Although SG and MRI-based EOR paradigms provide similar prognostic performance for predicting LFFR and OS in the era of molecular classification, MRI-based definitions may be preferred for future clinical trial inclusion criteria....

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🧠 Join the next #EANOYoungsters Journal Club! 𝗢𝗽𝗲𝗻𝗶𝗻𝗴 𝗖𝗹𝗼𝘀𝗲𝗱 𝗗𝗼𝗼𝗿𝘀 "Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial" 📅 14 July 2026 🕓 16:30 CEST Register for free: zoom.us/webinar/regi...

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1/n Excited to share our new paper in Nature Cancer 🦀 Meet Hetairos (Greek- “companion”): an AI model that predicts >100 methylation-defined CNS tumour subtypes directly from a routine H&E slide 🧠 State of the art diagnostics- from the slide that’s already on every pathologists’ desk 🧵

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