Gaetano Gargiulo
@ggargiul.bsky.social
Scientist, cancer researcher, studying brain & lung tumors and synthetic genetics, occasionally cooking and supporting Inter FC
Have you registered for #EANO2026 yet? Join the global #NeuroOncology community in Rome, Italy, from September 24–27, 2026. The #EANO Board is looking forward to welcoming you for four days of outstanding science, collaboration, and networking. 🎟 Register at the regular rate until August 12.
Gaetano Gargiulo@ggargiul.bsky.social · 2mo agoWe're finalizing the #BTM2026 scientific program and selecting the last short oral presentations. ⏳ Deadline extended: July 1 Join an exceptional international speaker line-up & help shape the discussion on brain tumors! 📍 Berlin | Oct 14–15, 2026 #NeuroOncology #BrainTumors
Welcome and congratulations to the 60 new members and 11 associate members who have been elected to the EMBO Membership! They join a community of more than 2,200 leading scientists. 🧪 https://www.embo.org/press-releases/seventy-one-leading-scientists-elected-to-the-embo-membership/ #EMBOMembers2026
We're finalizing the #BTM2026 scientific program and selecting the last short oral presentations. ⏳ Deadline extended: July 1 Join an exceptional international speaker line-up & help shape the discussion on brain tumors! 📍 Berlin | Oct 14–15, 2026 #NeuroOncology #BrainTumors
BTM is back! Berlin turns gold 🍂 this fall & #BTM2026 @mdc-berlin.de returns with an outstanding lineup plus a new feature: early registrants can suggest speakers and topics before the program is finalized. info: www.mdc-berlin.de/BTM2026 If you’re in the field, spread the word! #NeuroOncology
Brain Tumor Meeting 2026
Keynote Speakers:Leila Akkari, NLJeong Ho Lee, KRSimona Parrinello, UKBerta López Sánchez-Laorden, ESJeremy N. Rich, USDaniel Schramek, CABjörn Scheffler, DEGhazaleh Tabatabai, DE
mdc-berlin.de
Now online in Cancer Discovery @aacrjournals.bsky.social: Extrachromosomal DNA-Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers - by Giulia Montuori, Fengyu Tu, anton-henssen.bsky.social, Jan Dörr, and colleagues doi.org/10.1158/2159...
🚨We want your abstract! Submit your Late Breaking Abstract to #EANO2025 by June 25, 2025 to become an essential part of the state-of-the art scientific programme. 👉 Learn more: eano.eu/eano2025/abs... #NeuroOncology #NeuroSurgery #cancernurse #braintumor #btsm
first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer
Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...
nature.com
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity www.nature.com/articles/s41...
Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity - Nature
Inhibition of cyclooxygenase 1 releases T cells from immunosuppression by platelet-derived thromboxane A2, thereby enhancing the immune response against metastasis.
nature.com
"EMT favours the emergence of genomic-unstable, highly fit tumour cells, which strongly supports the concept of cell-state-restricted patterns of evolution" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!
Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature
Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...
doi.org
Understanding the basics is key to developing effective treatments. This framework on the myeloid side of brain tumors offers a systematic POV, with the dexa angle being particularly intriguing.
Programs, origins and immunomodulatory functions of myeloid cells in glioma - Nature
A study of myeloid cells in gliomas, a type of brain tumour, used a factor-based computational framework to reveal four immunomodulatory gene-expression programs that are expressed across myeloid cell...
nature.com
“We are almost ready for the test flight. All we need is the license." ...in Germany that may take much longer than developing and building the rocket 😂
Ars Technica@arstechnica.com · last yr.Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.
RNA polymerase II at histone genes predicts outcome in human cancer
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...
science.org
@science.org RNA polymerase II at histone genes predicts outcome in human cancer 🧬💊 @fredhutch.bsky.social @hhmi.bsky.social www.science.org/doi/10.1126/...
RNA polymerase II at histone genes predicts outcome in human cancer
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)–cl...
science.org
Fred Hutch@fredhutch.org · last yr.Researchers at Fred Hutch have discovered an overlooked mechanism driving aggressive breast and brain tumors involving genes so ancient — more than 2 billion years old — that they fly under the radar of standard genetic sequencing methods. 1/9 www.science.org/doi/10.1126/...
🔬 #FundamentalResearch is key for #EUcompetitiveness
EU-LIFE@eu-life.bsky.social · last yr.🔬 #FundamentalResearch is key for #EUcompetitiveness and to address global societal challenges 🌍 #Innovation leaders from the #biotech sector highlight the crucial role of #research for their work ⬇️ Since 2014, EU-LIFE institutes have contributed to #EU innovation ecosystem with over 80 #startups!
Normalize calling Republicans Nazis.
WuTangIsForTheChildren@wutangforchildren.bsky.social · last yr.🔥🔥🔥 Former Vikings punter Chris Kluwe was arrested for civil disobedience after speaking against a MAGA display that the city council of Huntington Beach agreed to put up at the public library…..that’s what’s up….every word👇
Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵 Open access link: www.nature.com/articles/s41...
1/I am delighted to share a new Cancer Discovery paper about metabolism and clinical outcomes in patients with non-small cell lung cancer (NSCLC). From Ling Cai and Brandon @faubert.bsky.social, @cri-utsw.bsky.social and UT Southwestern McDermott Center.
Elizabeth McKenna@elizsmckenna.bsky.social · last yr.Now online in Cancer Discovery: High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non–Small Cell Lung Cancer in Patients - by Ling Cai, Nia Hammond, Brandon Faubert, @rjdlab.bsky.social, and colleagues doi.org/10.1158/2159...
Injectable fluorescent retro-tracing of pancreatic cancer innervation. Denervation sensitizes PDAC to immunotherapy by counteracting neuronal suppression of acute inflammation in CAFs. Plus, tumor denervation as a novel mechanism behind the old nab-paclitaxel combo. Quite a characterization indeed!
Victor Javier@vjsanchez.bsky.social · last yr.Characterization of single neurons reprogrammed by #PancreaticCancer 🧪 www.nature.com/articles/s41...
Cell identity lives from constraints and dies from freedom
Moritz Mall@moritzmall.bsky.social · last yr.#CellPlasticity—the ability of cells to change their identity—is vital for tissue growth and repair. But when it goes unchecked, it can fuel #cancer. Our latest study examines how to block #LiverCancer by actively suppressing plasticity. www.nature.com/articles/s41... #CancerBiology
Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!
GuccioneLab@guccionelab.bsky.social · last yr.What an amazing cover! Congrats @gloglita.bsky.social
Proud to see our lab’s work contribute to this fantastic study, and specifically: "[...]We have recently developed a new strategy to genetically trace cell fate transitions within a heterogeneous tissue37,38 [...]" Check it out! 👇
GuccioneLab@guccionelab.bsky.social · last yr.Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social
1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social @owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder.A huge thanks to all our collaborators an to Slim for driving this project www.nature.com/articles/s41... @sleemmz.bsky.social @ggargiul.bsky.social
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
nature.com
Now online in Cancer Discovery: PKN2 Is a Dependency of the Mesenchymal-like Cancer Cell State - by Shane Killarney, Kris Wood and colleagues doi.org/10.1158/2159...
Academics get so jaded about institutions, when they reach a #leadership position many feel #researchculture is unactionable. Me and @deefitzgerald.bsky.social wrote a guide in @immunolcellbiol.bsky.social on leadership nurturing a positive culture 1/13 onlinelibrary.wiley.com/doi/10.1111/...
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...
onlinelibrary.wiley.com
