Ewen Callaway

@ecallaway.bsky.social

I'm an immigrant.

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Scientists have discovered the first known transmissible cancer in fish, the 4th naturally occurring cancer known to spread between animals Anglers noticed the disease in 2012 in bullhead catfish in a Vermont-Québec lake. Thoreau might even have seen it in the 1850s. www.nature.com/articles/d41...

Rare contagious cancer discovered in wild catfish

Transmissible tumours have been found in only a few types of animal, but there might be many more out there.

nature.com

another #Nature #News feature: from billion-fold volumetric expansion to in situ structural biology. www.nature.com/articles/d41... The recent #UMG - #MIT preprint shows what is possible on purified systems. Next challenge: same but inside intact cells a brilliant piece from @ecallaway.bsky.social

Making samples one billion times bigger lets simple microscopes pinpoint amino acids

Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light microscopy.

nature.com

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I'd love to hear evo/pop geneticists' thoughts. The argument that structure has been ignored feels like a straw-man. Odd not to quote anyone else working on this. There are many people with no connection to initial discovery. www.technologyreview.com/2026/04/14/1...

The problem with thinking you’re part Neanderthal

The idea that modern humans inherited DNA from Neanderthal ancestors is one of the 21st century’s most celebrated discoveries in evolution. It may not be that simple.

technologyreview.com

The results are finally in! 🏆💻🧬 I'm thrilled to announce that the manuscript for the Bits to Binders protein design competition is out on bioRxiv! Here's a summary of our findings, including some simple criteria that nearly *double* success rates when applied as a filter 🧵

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Ewen's writeup of the new Evo 2 paper in Nature is reliably good. I can imagine this foundation model will be useful for doing synthetic biology in microbes. But it's important to recognize that making this work for eg humans is not just a scaling-up issue... www.nature.com/articles/d41...

AI can write genomes — how long until it creates synthetic life?

The Evo2 genomic language model can generate short genome sequences, but scientists say further advances are needed to write genomes that will work inside living cells.

nature.com

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After 5 years, 150k papers and 17 million genomes, here's what we learned about SARS-CoV-2 and viruses in general. It holds lessons for future pandemics - only if we listen. "We’re in a worse place in terms of pandemic prevention" @eddieholmes.bsky.social told me. www.nature.com/articles/d41...

Four ways COVID changed virology: lessons from the most sequenced virus of all time

After 150,000 articles and 17 million genome sequences, what has science taught us about SARS-CoV-2?

nature.com

I feel so strongly about the need for evidence-based policy and a dogged defence of science I said it in 2020, and will reiterate it til the end of time. The world may change - our principles should not

PLOS Biology@plosbiology.org · last yr.

In 2025, we continue to advocate for policy based on scientific evidence. This 2020 Editorial, “We need leaders that believe in scientific evidence”, resonates today as loudly as ever: plos.io/34lyl59. PLOS Biology also continues to push for DEI and a diverse scientific community: plos.io/3rzxczU 🧪

This is indeed a great story from Ewen (Science magazine has reported on this too). Ewen makes it properly clear that there are many questions about the functionality (or not) of all these "mini-proteins". Many may turn out to be "junk peptides". BUT...

Brendan Maher@bmaher.bsky.social · 2y ago

If you need a bio-break from all the political news in the US, this extremely geeky exploration of 'dark proteins' is a great read www.nature.com/articles/d41...

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The 2024 Nobel prize in physiology or medicine has been awarded to Victor Ambros and Gary Ruvkun, who discovered microRNAs, a class of tiny RNA molecules that help to control how genes are expressed in multicellular organisms. Read the Nature article. 🧪

Medicine Nobel awarded for gene-regulating ‘microRNAs’

Victor Ambros and Gary Ruvkun identified a class of tiny molecules that have a crucial role in controlling gene expression.

go.nature.com