Ali Shaib
@alishaib.bsky.social
I do science for a living. Group leader at UMG Göttingen. Opinions my own. X: @AliHShaib, my lab: https://www.neuro-physiol.med.uni-goettingen.de/dr-ali-shaib/
#congratulations to Janna, Markus and the team! By combining 8× expansion with #dSTORM, we resolved the 8 nm spacing between neighboring tubulin molecules and revealed ~44 nm RIM/Munc13-1 rings in neurons. Thank you for letting us contribute a small part. story: rdcu.be/fwBYY #cool #imaging #tiny
on 13 August, we welcome Prof. Dr. Liangyi Chen from PKU for an SFB 1286 seminar in #Göttingen. discussing #live-cell and cross-scale #imaging reveal #disease mechanisms, from #rare #disorders to #diabetes. 📍 Manfred Eigen Lecture Hall ☕ 13:00 Coffee and refreshments 🎤 13:30 Lecture 🍽️ 14:45 Lunch
Our new work is now published in Engineering Applications of Artificial Intelligence, where we investigate whether #quantum #ai can improve #biomedical #image #analysis and identify where it offers measurable advantages over classical AI. Story: authors.elsevier.com/a/1nPV93OWJ9...
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Sharing a big update: I started a group at the MPINAT in Göttingen! We will develop AI for analyzing how proteins interact in the cellular environment based on cutting edge imaging. This appointment is in parallel to the university, where I will retain my current group.
MPI for Multidisciplinary Sciences@mpi-nat.bsky.social · 4w agoAI meets cutting-edge microscopy: Welcome Constantin Pape, head of our new Machine Intelligence in the Life Sciences group! 👋 🔬 His team develops AI methods to analyze high-resolution microscopy & cryo-EM data to better understand the function of proteins and protein complexes inside cells. (1/3)
calling it a day. manuscript submitted, portal survived, one episode of 'daemon of the shadow realm' earned
in this #review, we argue: #AI is becoming a new pillar of #LifeScience research. Beyond data analysis, AI is beginning to contribute to scientific reasoning, experimental design, molecular #discovery, and laboratory automation, reshaping how biological research is done. pubs.acs.org/doi/10.1021/...
jelly is just under-appreciated. Playing with it is Good and Necessary
another #Nature #News feature: from billion-fold volumetric expansion to in situ structural biology. www.nature.com/articles/d41... The recent #UMG - #MIT preprint shows what is possible on purified systems. Next challenge: same but inside intact cells a brilliant piece from @ecallaway.bsky.social
Making samples one billion times bigger lets simple microscopes pinpoint amino acids
Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light microscopy.
nature.com
From cells to amino acids: 1000ExM pushes expansion microscopy even further 🔬 #microscopy @fadelvalle.bsky.social covers an impactful #preprint from the labs of @bergerlab.bsky.social, @alishaib.bsky.social, Silvio Rizzoli & @eboyden3.bsky.social #preLight⬇️ prelights.biologists.com/highlights/t...
Thousandfold Expansion Microscopy - preLights
From cells to amino acids: 1000ExM pushes expansion microscopy beyond 1000×, potentially resolving individual protein residues on standard microscopes. Bigger volume expansion opens a new frontier for...
prelights.biologists.com
Content not paid for by @abberior.rocks 😅 www.linkedin.com/posts/exm-ex...
#exm #expansionmicroscopy #sted #singlemoleculeimaging #stardyes #abberior | abberior
𝗘𝘅𝗽𝗮𝗻𝘀𝗶𝗼𝗻 𝗺𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆 physically enlarges the sample, but it also dilutes fluorophores, exposes them to harsh chemistry, and leaves them in a water-rich gel. Not every dye survives that. Ali Shaib and...
linkedin.com
I’ve spent many nights over many years wondering if something like this was possible. So impressed to see it happen!
The specimen has reached the minimum size requirement for a faculty position 😄
Reto Fiolka@retof.bsky.social · 2mo agoThe 1000x mouse would be of a similar size as a Boeing 747 or Airbus 380. Should fit nicely in a large aircraft hangar.
OH lol I thought you meant S. Figs 6 and 7 LOLOLOL I do like this for a graphical abstract though!
The scientific community and two Editors-in-Chief are supporting Supplementary Figure 67 to be included in the manuscript. I'll pitch this idea with the other co-authores 😄 Wish me luck, haha Story: www.biorxiv.org/content/10.6...
Rita Strack@ritastrack.bsky.social · 2mo agoOf course! Why not?
At this rate, if I get the ERC CoG, the next generation of proteins may indeed require their own postal codes.
Kai Murk@kaimurk.bsky.social · 2mo agoThis is absolutely crazy. 1000x expansion microscopy. I guess the next challenge is to build a microscope fitting for the 3.5 m specimen. Absolutely astonishing...
forget the use of a lens to magnify an object, here comes the age of magnification of objects themselves 😱
Ali Shaib@alishaib.bsky.social · 2mo agoHello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...
In this #MIT – #UMG collaboration, we asked: if making #biology 10× larger helped #microscopy, what happens at 1,000×? Apparently, the sample becomes large enough to join the #discussion. Our preprint on Thousandfold Expansion Microscopy: www.biorxiv.org/content/10.6... #superresolution #science
Ali Shaib@alishaib.bsky.social · 2mo agoHello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...
1000x linear expansion. Who would have thought this would be possible - From the inventor of the original expansion microscopy - This is absolutely fantastic! - Expansion microscopy is one of the most creative methods I have ever heard of in my 40 years of being a scientist - CONGRATS!
Ali Shaib@alishaib.bsky.social · 2mo agoHello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...
🤯
Ali Shaib@alishaib.bsky.social · 2mo agoHello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...
Star Demands More!
ALT: Star Demands More!
static.klipy.com
Ali Shaib@alishaib.bsky.social · 2mo agoHello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...
Wow - just wow - well done Ali Shaib @eboyden3.bsky.social and colleagues! 1000x expansion microscopy is here!
Ali Shaib@alishaib.bsky.social · 2mo agoHello #world, meet 1,000× Expansion Microscopy. A small gel would grow to the size of an Olympic swimming pool, while amino-acid-scale distances become visible with ordinary light microscopy. Led by Helena Hu from @eboyden3.bsky.social's lab, in collab with us. Story: www.biorxiv.org/content/10.6...
wait, so that gel was initially 0.35 cm and is now 3.5 METERS ??? 😱
