Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

SPACEtomo v1.3 is now available! What's new? - Lots of tools for setting up targets on non-lamella samples - Option for reacquisition of specific maps (e.g. after ice contamination cleaning) - Bug fixes and more robust Give it a try and let me know what is still missing! github.com/eisfabian/SP...

Thanks to an @snf-ch.bsky.social Starting Grant, my group will move to the Institute of Medical Microbiology at University of Zürich in summer 2025. Let's move cryoET literally next to the clinics and investigate bacterial pathogens from molecules to the patient #FreezeInTheClinics 🏥❄️🔬

SPACEtomo v1.2 is online! github.com/eisfabian/SP... - Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample. - Easier installation and configuration Any feedback is much appreciated! :)