Granule cells predict future dopamine reward. Delayed climbing-fiber signals can reinforce the action that precedes it. Our paper, led by Benjamin Filio, is out today in Nature Neuroscience. www.nature.com/articles/s41... Public PDF: rdcu.be/RscCNeXvkXAa

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

A pyramidal cell in the mouse medial frontal cortex #FluorescenceFriday h/t Jiajun Li on the confocal 🔬🧠🧪

Sunday read: 'Purkinje cell intrinsic activity shapes cerebellar development and function' www.nature.com/articles/s41...

Why is the #cerebellum (known for coordinating motor functions) also engaged in #cognition? @diedrichsenjorn.bsky.social & @actlab.bsky.social investigate the problems that have made it so difficult to answer this question and outline strategies to make progress. 🧪 #NeuroSky

How does the cerebellum contribute to cognitive functions?

The role of the cerebellum in motor functions is well understood. But why is the same circuitry engaged in functions such as working memory, language, and social cognition? This Unsolved Mystery…

plos.io

Our manuscript showing cerebellar nuclei impacts on distal cortical activity, structure, and social behavior is now out! 🧪🔬 www.nature.com/articles/s41...

Attenuation of social preference and alteration of cortical neurons following adolescent cerebellar nuclei perturbation - Molecular Psychiatry

Molecular Psychiatry - Attenuation of social preference and alteration of cortical neurons following adolescent cerebellar nuclei perturbation

nature.com

One of the most beautiful things in the world❤️ #patchclamp #EIRatio

🧠 Opportunity for a post-doctoral position on human neurobiology, funded by the @erc.europa.eu! 🧫You want to use human pluripotent stem cell based models to understand the evolution of human cerebellar neurons and disorders, this position is for you! 🔗Apply here: emploi.cnrs.fr/Offres/CDD/U...

Had such wonderful days in Oslo for #FRM2025. It was a well-organized and truly inspiring conference! Thanks to everyone who stopped by my poster on the role of #cerebellar Purkinje cells in a mouse model of #autism, I really appreciated all your comments and feedback!

A very nice Insight article in eLife by Ikuko Smith on our forthcoming eLife paper on non-ionotropic presynaptic NMDA receptor signalling in spike-timing-dependent long-term depression. elifesciences.org/articles/107...

Synaptic Plasticity: A new mode of action for unconventional NMDA receptors

Presynaptic NMDA receptors can shape timing-dependent long-term depression in a way that departs from their classic postsynaptic role.

elifesciences.org

New preprint alert 📣 #Cerebellum, organoid, autism & brain evolution 🧪 🧫🧠🧬 Collaboration with G. Testa; fruit of years of work by smart students, led by postdoc Davide Aprile. Organoids to understand better the developmental basis of autism (focus: CHD8) & sapiens brain evolution (focus: CADPS2) 🧵

Benchmarking cerebellar organoids to model autism spectrum disorder and human brain evolution

While cortical organoids have been used to model different facets of neurodevelopmental conditions and human brain evolution, cerebellar organoids have not yet featured so prominently in the same cont...

biorxiv.org

Cerebellar mf-GoC synapses show anti-symmetric STDP, driven by action potential timing, NMDA receptor activation, and Ca²⁺ dynamics, with inhibitory input capable of reversing the plasticity rules. @elepali.bsky.social www.nature.com/articles/s42...

Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells - Communications Biology

Cerebellar mf-GoC synapses show anti-symmetric STDP, driven by action potential timing, NMDA receptor activation, and Ca²⁺ dynamics, with inhibitory input capable of reversing the plasticity rules.

nature.com

Excited to share my PhD work on spike-timing dependent plasticity in cerebellar Golgi cells, just published with @springernature.com in @commsbio.nature.com. Read here: rdcu.be/elN6L

Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells

Communications Biology - Cerebellar mf-GoC synapses show anti-symmetric STDP, driven by action potential timing, NMDA receptor activation, and Ca²⁺ dynamics, with inhibitory input...

rdcu.be

Made a starter pack for researchers who are actively working on or have an interest in the cerebellum. DM me to be added or reply to this thread! 🧠🤏🏻 go.bsky.app/7X4ekSH #neuroscience #neuroskyence #cerebellum #neuroimaging #dbs #fmri

A black and white offering for the post-Thanksgiving #FluorescenceFriday. Cerebellum, because one never forgets one's first love 🤍🖤🐭 #neuroskyence #microscopy

Could not believe such thing did not exist. Let me know if you want to be added (/removed) go.bsky.app/RuCRCgX

Are you building a patch-clamp setup, and would like a cheap heating system? Have you ever wondered how temperature changes the membrane properties of MSNs? Then you might like our latest paper, out now! www.nature.com/articles/s41...

A low-cost perfusion heating system for slice electrophysiology - Scientific Reports

Scientific Reports - A low-cost perfusion heating system for slice electrophysiology

nature.com