For those of you who approached me at @microbiologysociety.org #Microbio25 (and anyone else interested!!), this is your last chance to apply for our PDRA position. Come join us in Glasgow!

Giusy Mariano@giusym1990.bsky.social · 2y ago

🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44

If you're still at #MircoBio25, head down to poster 89 and catch up with all the work that @phoebecrossley.bsky.social is up to as part of her PhD in my lab #microsky #vaginalmicrobiome

New paper from the group - here we show that aurodox prevents shiga toxin mediated damage in a murine model. Interesting changes to the microbiota too. Amazing work by @rebeccamchugh.bsky.social and the group. Paper here- rdcu.be/efW0K

The most worrisome is that this strain is a well know producer of the colibactin genotoxin, which may be associated with colorectal cancer bsky.app/profile/them...

Tommi Mäklin@themaklin.bsky.social · 2y ago

New paper: We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers. www.sciencedirect.com/science/arti...

🚨 #PhD opportunity! 🚨 Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬 Details here: www.strath.ac.uk/studywithus/...

Eva Heinz@evaheinz7.bsky.social · 2y ago

And another #PhD, again @unistrathclyde.bsky.social in the very friendly, open-minded and diverse Glasgow! #Enterococcal #phages and their role in infections - how much do they contribute to success of nosocomial pathogens? Details here, led by Suzie Humphrey 😊 www.strath.ac.uk/studywithus/...

🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44

New Scientist (@newscientist.bsky.social) wrote a feature on our work! 🧪✨🔬 We made the first fully 3D printed microscope, with potential for rapid customisation and low-cost manufacturing. newscientist.com/article/2462618-worlds-first-fully-3d-printed-microscope-made-in-under-3-hours/

World’s first fully 3D-printed microscope made in under 3 hours

The microscope cost less than £50 to build using an open-source design and a common 3D printer

newscientist.com

Liam Rooney@liam-rooney.bsky.social · 2y ago

🚨 New pre-print out! 🚨 The world’s first fully 3D printed microscope! Is Santa bringing you a 3D printer for Christmas, or maybe you need a gift for your favourite microscopist - print the lenses, print the frame, and start imaging! ✨🔬 Check it out below and please repost!👇🏻🙏🏻 (1/N)

go.bsky.app/CJyjtir A starter pack of researchers in bacteriology at the University of Glasgow. Will be updated as members of the department join bsky. 🔬🧬🧫🥼

New paper from the group. Very proud to share our recent work for the first time here on Bluesky- give me 50 likes and it’s a permanent move!🤣. doi.org/10.1098/rsob...

Our second paper on the bacterial toxin colibactin is now out on mBio, this time we critically evaluated the claim that colibactin toxicity necessitates cell-cell contact 🧪🦠🧵(1/9) journals.asm.org/doi/10.1128/...

Colibactin-producing E. coli 🦠 uses adhesin proteins to bind to colon cells, driving DNA damage 🧬 and tumor growth in #CRC. Blocking this binding with targeted inhibitors could open paths to anti-cancer therapies! 🌟! #Microbiome #ColorectalCancer #GutHealth #ImmunoSky www.nature.com/articles/s41...

Colibactin-driven colon cancer requires adhesin-mediated epithelial binding - Nature

The oncogenic potential of pks+ Escherichia coli depends critically on bacterial adhesion to host epithelial cells mediated by the type 1 pilus adhesin FimH and the F9 pilus adhesin FmlH.

nature.com

New paper: We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers. www.sciencedirect.com/science/arti...

Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli

Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…

sciencedirect.com

I wrote a short blog post for the Microbiology Society regarding our recent colibactin regulation review. Available here. @sofiasandalli.bsky.social @drandyjroe.bsky.social

Regulation of a carcinogenic genotoxin

<span style="font-family:&quot;Calibri&quot;,sans-serif; font-size:11.0pt; mso-ansi-language:EN-GB; mso-ascii-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-language:AR-SA; mso-bidi-them...

microbiologysociety.org

Really pleased to share Curtis Cottam’s first paper from his PhD, where he discovered a new Arabinose transporter in pathogenic E.coli and investigated the impact of Arabinose utilisation on virulence gene regulation. www.biorxiv.org/content/10.1...

Metabolism of ʟ -arabinose converges with virulence regulation to promote enteric pathogen fitness

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

biorxiv.org

@sofiasandalli.bsky.social @drandyjroe.bsky.social and I wrote a little review about colibactin, with a brilliant graphical abstract by Iris Floria. You can read it here: go.shr.lc/42t0SCb

Current understandings of colibactin regulation

The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA – S) within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup. Colibactin is a pote...

go.shr.lc

BBSRC NorthWest Bio Fully Funded Doctoral Training Programme #Studentship with me & @lore-fermar.bsky.social on understanding how antibiotic producing #Streptomyces bacteria adapt to their environment & how reproducible mutations are-Pls share-Details here www.gla.ac.uk/postgraduate...