Bacteriology-Focused Assistant Professor Position in Microbiology and Immunology at the University of Michigan Application deadline: August 15, 2026 Come be my colleague!
James Connolly
@ruamicro.bsky.social
MRC Career Development Fellow at Newcastle University. Studying how pathogens control their genes
"In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infection, leading to a brain abscess." Don't mess with Klebs. #UTISky #UTI #IDSky
Andreas Peschel @andreaspeschel.bsky.social · 2w agoWhat drives hypervirulence and resistance of the ESKAPE pathogen Klebsiella pneumoniae? Check this exciting story by @dzif.bsky.social Prof. Christoph Ernst Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract | New England Journal of Medicine www.nejm.org/doi/10.1056/...
The adaptive landscapes of three global Escherichia coli transcriptional regulators @elife.bsky.social by @cauawest.bsky.social et al elifesciences.org/articles/103...
Are you going to Genome Science UK 2026 in Manchester 14th-16th September? We know life can get extra busy 😧 before the summer holidays 🏖️ so we've extended abstract submission deadline to 24th July & early bird registration deadline to 10th August 😁 Check out the agenda 🧬🧬 www.genomescience.org.uk
Genome Science UK 2026
Manchester University
genomescience.org.uk
Have you registered for Genome Science yet? www.genomescience.org.uk Its going to be in mad for it Manchester September 14th-16th 2026. Lots of great microbial genomics and bioinformatics speakers so make sure you secure a place. Early bird registration ends on 31/7/26.
Liam Gallagher: Oasis Rooftop Walk
ALT: Liam Gallagher: Oasis Rooftop Walk
static.klipy.com
1/ Excited to share a new preprint! My PhD student Claire asked why neonatal mice become resistant to experimental cholera as they age. Turns out, early-life acquisition of maternally transmitted lactobacilli helps protect against experimental cholera www.biorxiv.org/content/10.6...
Early-life acquisition of Lactobacillaceae protects against experimental cholera
Cholera causes severe diarrheal illness in young children, but the mechanisms underlying age-dependent susceptibility remain unclear. Experimental cholera in neonatal mice recapitulates age-dependent ...
biorxiv.org
Fantastic opportunity to join a brilliant lab and wider collaborative team!
Georgia Isom@georgiaisom.bsky.social · 4w agoInterested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria. The deadline is 31st July. Informal enquires are welcome. Please share!
🚨Join us at the University of Geneva! We're seeking an outstanding junior researcher to apply for an ERC or SNSF Starting Grant with our institutional support in host–pathogen interactions, bacteriology, virology, parasitology, or mycology. www.unige.ch/medecine/mim... Please share!
Open call : MIMOL Junior Group Leader’s application for a Starting Grant - Microbiology and molecular medicine - UNIGE
unige.ch
[🚨] Publication alert! Years of hard work is now published in @pnas.org - www.pnas.org/doi/full/10.... It's not everyday that a novel biosynthetic intermediate is identified in bacteria, so this warrants a short summary below [👇] 1/7
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Huge congratulations to @rhyswg.bsky.social and colleagues for this behemoth of a paper shedding light onto the mechanism of pyocins and their impact on cell function.
L-type pyocins inhibit the BAM complex to kill without cell entry - Nature Communications
L-type pyocins are a class of bacteriocin-like proteins with antibacterial activity. Here, the authors show that these proteins kill the pathogen Pseudomonas aeruginosa by inhibiting the BAM complex a...
nature.com
Another collaborative paper from the @ilango-aravind.bsky.social & @heathmurraylab.bsky.social team, here focused on the essential DNA replication initiation protein DnaB in Bacillus subtilis. Credit to Aurélie Guyet, Fred Schramm and @winterhalterlab.bsky.social academic.oup.com/nar/article/...
Validate User
academic.oup.com
A pleasure to work with Zong. Our latest paper covering 10 years of CRKP surveillance in south west China shows ST11 KL64 CRKP carrying a hypervirulence plasmid. But no increase in patient mortality. What does increase is gut translocation and invasive infections. www.nature.com/articles/s41...
Enhanced invasiveness promotes the dominance of a widely-distributed carbapenem-resistant virulence-plasmid-carrying Klebsiella pneumoniae sublineage - Nature Communications
This long-term genomic surveillance identifies a widely disseminated carbapenem-resistant Klebsiella pneumoniae (CRKP) sublineage with enhanced invasiveness but no increased mortality, revealing immun...
nature.com
We are recruiting a lab manager for my group in Oxford. This is a lovely team doing great things, and you could be an important part of it! See here: www.path.ox.ac.uk/vacancy/lab-... Please spread the word!
Lab Manager - Molecular Immunology - Dunn School
Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford
path.ox.ac.uk
Faculty search announcement 2026: Tenure-Track Assistant Professor in Microbiology at UT Southwestern in Dallas. We seek candidates working in microbial pathogenesis (broadly defined). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics www.nature.com/articles/s41...
A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics - Nature
In Streptomyces spp., a conserved biosynthetic gene megacluster produces an arsenal of distinct antimicrobials that converge on bacterial biotin biosynthesis as a naturally evolved combination therapy...
nature.com
New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
A Type VII-secreted toxin enables inter-mycobacterial competition - Nature Communications
Mycobacteria have not yet been reported to engage in interbacterial competition via secretion of proteinaceous toxins. Here, Benedict et al. show that some mycobacteria can use their type-VII secretio...
nature.com
Out after a lot of hard work from many people. When we first found arabinanase enzymes in mycobacteria we started looking into their roles in cell remodelling & pathogenesis. Did not expect to find that some species had weaponised them to kill competitors! Myco are endlessly surprising. #glycotime
Patrick Moynihan@pmoyniha.bsky.social · last mo.New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · last mo.A novel reverse lipase toxin substrate of the Staphylococcus aureus type VII secretion system https://www.biorxiv.org/content/10.64898/2026.06.22.733114v1
New preprint from our lab, in collaboration with the Santiago/Ruiz-Perez group at UVA. We found a plasmid-encoded DNA-binding protein that preferentially binds its own plasmid! www.biorxiv.org/content/10.6... Thread:
A plasmid-encoded H-NS protein selectively binds its own plasmid
H-NS is an abundant nucleoid-associated protein found in Enterobacterales species. Some conjugative plasmids encode H-NS homologues, which are thought to facilitate plasmid maintenance and reduce the ...
biorxiv.org
Cool new plasmid work from Joe Wade's lab at the Wadsworth Center! Lots of conjugative plasmids encode Histone-like nucleoid-structuring protein (H-NS) proteins, and there's increasing evidence they somehow specifically bind to the plasmids that encode them #microsky #plasmidsky
Joe Wade@joe-wade.bsky.social · last mo.New preprint from our lab, in collaboration with the Santiago/Ruiz-Perez group at UVA. We found a plasmid-encoded DNA-binding protein that preferentially binds its own plasmid! www.biorxiv.org/content/10.6... Thread:
🫴 Processing of reversed replication forks is required for the resolution of replication-transcription conflicts ! 👇 academic.oup.com/nar/article/... #subtiwiki
Processing of reversed replication forks is required for the resolution of replication-transcription conflicts
Abstract. DNA replication and transcription occur simultaneously on the same template, leading to conflicts between the two machineries. Conflicts stall re
academic.oup.com
Very nice work on sugar transport during Proteus UTI
Selective sugar transport supports Proteus mirabilis fitness in the urinary tract
Author summary All living organisms require nutrients to grow, survive, and cause disease. Bacteria like Proteus mirabilis, which causes urinary tract infections, rely on specialized systems to import...
journals.plos.org
Really lovely work, Marjon & team, puts us closer to being able to decipher #UTI diagnosis based on sequencing - currently difficult in my view, with dozens of strains detected and never being entire sure what the pathogen(s) is/are. We need to understand entire signatures better. #UTISky #IDSky
Marjon de Vos@lizscurious.bsky.social · last mo.Cross-study metagenomics analysis reveals distinct microbial signatures of urinary tract infections www.biorxiv.org/content/10.6... #UTISky
Is colorectal cancer driven by a disruption of anaerobiosis? A recent study by Spiga et al. makes this idea walk and talk like a duck. Read more here: www.sciencedirect.com/science/arti...
An anaerobic pathogen rewires host metabolism to fuel oxidative growth in the inflamed gut
To colonize their host and cause disease, enteric pathogens must deploy their virulence factors to establish distinct nutrient niches. How anaerobic p…
sciencedirect.com
Now published in Cell Reports! @cellpress.bsky.social www.cell.com/cell-reports... My postdoc Dr. Maria de la Paz Gutierrez led this work showing that cholera toxin drives epithelial L-lactate production in the small intestine, creating a nutrient that Vibrio cholerae exploits during disease
Cholera-toxin-induced disease generates epithelial-cell-derived L-lactate that promotes Vibrio cholerae growth in the small intestine
Gutierrez et al. show that cholera toxin induces epithelial LDHA-dependent L-lactate production in the small intestine, creating a nutrient niche that Vibrio cholerae exploits through LldD-mediated L-...
cell.com
Fabian Rivera-Chávez@fabianrchavez.bsky.social · 12mo ago1/ Excited to share the first preprint from my lab! 🎉 My postdoc Paz asked how cholera toxin (CT) helps Vibrio cholerae thrive in the gut. Turns out, CT rewires epithelial metabolism toward L-lactate production—fueling pathogen growth in the small intestine during disease
Happy to share the last publication of @bobytaillefer.bsky.social, showing that #T6SS heterogeneity is an attenuation strategy to optimizes the trade-off between competitive killing and survival.
PLOS Biology@plosbiology.org · 2mo agoThe T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45
Opportunity for someone interested in a full time permanent lectureship in Environmental Microbiology and Biotechnology at @uccmicrobiology.bsky.social www.jobs.ac.uk/job/DRS979/l...
Lecturer (Above the Bar) in Environmental Microbiology & Biotechnology at University College Cork
Discover an exciting academic career path as a Lecturer (Above the Bar) in Environmental Microbiology & Biotechnology at jobs.ac.uk. Don't miss out on this job opportunity - apply today!
jobs.ac.uk
Latest research from the lab out now. We examined the role and expression of fimbriae during UPEC bloodstream infection. A real team effort and brilliant collaboration with Mark Schembri’s lab in Brisbane. Thanks to the MRC and BBSRC for supporting our research @ukri.org
Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection
Author summary Extraintestinal pathogenic Escherichia coli (ExPEC) colonise the human gut without causing disease but can disseminate to the urinary tract and bloodstream. Understanding the mechanisms...
journals.plos.org