Check out the latest work from the lab published today!

Bruno Di Stefano@distefanolab.bsky.social · last yr.

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

New preprint from the lab! With @brumbaugh-lab.bsky.social , we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. www.biorxiv.org/content/10.1...

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Recent studies have emphasized the significance of biomolecular condensates in modulating gene expression through RNA processing and translational control. However, the functional roles of RNA condens...

biorxiv.org

Happy to say our paper with the Whipple lab on snoRNA target profiling with chimeric eCLIP is now out! Great work by co-first authors Joey & Min with the help of a bunch of other folks! genomebiology.biomedcentral.com/articles/10....

Mapping snoRNA-target RNA interactions in an RNA-binding protein-dependent manner with chimeric eCLIP - Genome Biology

Background Small nucleolar RNAs (snoRNAs) are non-coding RNAs that function in ribosome and spliceosome biogenesis, primarily by guiding modifying enzymes to specific sites on ribosomal RNA (rRNA) and...

genomebiology.biomedcentral.com

Check out the latest review from the Di Stefano lab! For anyone interested in condensates in gene reg and their implications for immunology/cancer.

Bruno Di Stefano@distefanolab.bsky.social · 2y ago

1/ Pleased to share our review, published today @natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...

Historic Houston snowstorm brings out the #TMC3 snowmen (and children)

Excited to share my first manuscript in the @distefanolab.bsky.social , now out in @emboreports.bsky.social! 🎉 We demonstrate how two transposable elements, MER51B and LTR5_Hs, serve as selective indicators of human pluripotency states embopress.org/doi/full/10..... 🧵 below:

Transposable element activity captures human pluripotent cell states | EMBO reports

imageimageA novel dual reporter system based on transposable elements LTR5_Hs and MER51B enables precise tracking of human pluripotent stem cell states. This system reveals also a rare, metastable pri...

embopress.org

The latest paper from the Di Stefano lab showing the power of using transposable elements as reporters of different human pluripotent states! www.embopress.org/doi/full/10....

Transposable element activity captures human pluripotent cell states | EMBO reports

imageimageA novel dual reporter system based on transposable elements LTR5_Hs and MER51B enables precise tracking of human pluripotent stem cell states. This system reveals also a rare, metastable pri...

embopress.org

Happy to have the Srinivas lab on Bluesky! Even our embryos are starting to feel a little festive in the Srinivas lab! We are excited to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo www.biorxiv.org/content/10.1...