🆕 ADVANCE ONLINE 🆕 REVIEW: Mechanisms coordinating exit from the stem cell state in mammals By Park, Levin-Ferreyra and Bruno Di Stefano ➡️ https://ow.ly/siz250Za9Wh Bruno Di Stefano Baylor College of Medicine #stemcell #embryogenesis #celldifferentiation

Check out our new preprint: (www.biorxiv.org/content/10.6...) that highlights estrogen signaling in trophoblast development. Our data suggest that increased dosage of NRIP1 impairs this pathway, contributing to placental defects linked to Down syndrome. Great work @deirdrelogsdon.bsky.social & team!

My lab @bcmhouston.bsky.social is hiring a postdoctoral fellow to study hematopoiesis and leukemia using innovative degron mouse models, RNA recording technologies, and functional genomics approaches. If you are interested, please see the position details below:

Dr. Bruno Di Stefano (Bruno Di Stefano) Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!

Elevate your career in stem cell science! Become an ISSCR member to enjoy exclusive benefits: complimentary webinars, preferred rates for events including ISSCR 2026, publishing benefits, and access to an international network. Join today 👉 https://bit.ly/4eOL2H1 Bruno Di Stefano

Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology

Stem cell differentiation is controlled by manipulating RNA condensates.

go.nature.com

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology

Stem cell differentiation is controlled by manipulating RNA condensates.

nature.com

Excited to present at the CSHL Cell Fate Conversions 2025 meeting! Connect with me there to discuss whether your research is a fit for publishing in @stemcellreports.bsky.social. invt.io/1bxba296yhc #cshldirect

Check out ISSCR's society journal, Stem Cell Reports!

invt.io

Excited to join the Stem Cell Reports team as an Early Career Editor! Grateful for the opportunity to contribute to the journal alongside fantastic colleagues. I encourage you to submit your work for consideration! @isscr.org @stemcellreports.bsky.social

Check out ISSCR's society journal, Stem Cell Reports!

invt.io

New preprint from the lab! With @brumbaugh-lab.bsky.social , we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. www.biorxiv.org/content/10.1...

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Recent studies have emphasized the significance of biomolecular condensates in modulating gene expression through RNA processing and translational control. However, the functional roles of RNA condens...

biorxiv.org

Thrilled to share our new work on #aging in the murine hematopoietic system! There is a lot here- stem cell numbers, self-renewal rates, mutation rates, mutation signatures, clonal fitness, environmental effects...

Chiraag Kapadia@chiraagkapadia.bsky.social · last yr.

Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis www.nature.com/articles/s41...

🥂Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration. rdcu.be/d8awu www.nature.com/articles/s41...

H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium

Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...

rdcu.be

Review @natrevimmunol.bsky.social @distefanolab.bsky.social Biomolecular condensates in immune cell fate www.nature.com/articles/s41...

Biomolecular condensates in immune cell fate - Nature Reviews Immunology

Recent studies suggest that biomolecular condensates — membrane-less assemblies of proteins and nucleic acids — are involved in regulating gene expression to ensure proper immune cell development. Thi...

nature.com

1/ Pleased to share our review, published today @natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...

Biomolecular condensates in immune cell fate - Nature Reviews Immunology

Recent studies suggest that biomolecular condensates — membrane-less assemblies of proteins and nucleic acids — are involved in regulating gene expression to ensure proper immune cell development. Thi...

nature.com

Great thread from @levin-ferreyra.bsky.social about her latest work in the lab, out today in @emboreports.bsky.social ! 👇

Florencia Levin Ferreyra@levin-ferreyra.bsky.social · 2y ago

Excited to share my first manuscript in the @distefanolab.bsky.social , now out in @emboreports.bsky.social! 🎉 We demonstrate how two transposable elements, MER51B and LTR5_Hs, serve as selective indicators of human pluripotency states embopress.org/doi/full/10..... 🧵 below: