Computational molecular evolution

The need for effective and informed analysis of biological data is increasing with the explosive growth of genomic data. A phylogenetic framework is central to many molecular evolutionary approaches …

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Ancient Rapid Radiation Underlies Persistent Phylogenomic Conflict in Early Collembola Diversification

Collembola (springtails) are among the most abundant and ecologically important soil arthropods, representing one of the oldest extant terrestrial hexapod lineages, with a fossil record extending to t...

biorxiv.org

Models trained with noisy genomes extend bacterial phenotype prediction into deep time

Predicting phenotype from genotype in extant organisms is increasingly tractable through the accumulation of genome sequences and the development of machine-learning algorithms. Here we show that mach...

biorxiv.org

The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking - Nature Communications

COMMD proteins assemble into a heterodecameric ring in the Commander complex, which plays a role in endosomal membrane trafficking and signalling in eukaryotes. Here, Liu et al. identify COMMD-like pr...

nature.com

uu.nl

AliFilter: a Machine Learning Approach to Alignment Filtering

AbstractIntroduction. Multiple sequence alignments are a crucial step in many bioinformatic and computational biology analyses, from protein structure and

academic.oup.com

Research Associate in Microbial Genomics:Manchester

This postdoctoral research position is part of a Cystic Fibrosis Canada Early Career Investigator Award funded for 3-years led by Dr. Fabrice Jean-Pierre and Dr. Fiona Whelan. The aim of this project is to identify the genetic changes that arise in the Pseudomonas aeruginosa genome following perturbations – such as antibiotic treatment – in an in vitro system. The PDRA will use a large dataset of P. aeruginosa genomes and experimental metadata to predict key mutationsto the organism.

jobs.manchester.ac.uk

Screening, sorting, and the feedback cycles that imperil peer review

The process of peer review is vital to contemporary science, but is also under enormous strain. This study uses mathematical models to dissect the threats to the long-term viability of peer review, su...

journals.plos.org

Postdoctoral Research Associate - Grade 7 at University of Liverpool

An opportunity for an academic position as a Postdoctoral Research Associate - Grade 7 is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

jobs.ac.uk

The prokaryotic origins of the COMMD protein family involved in eukaryotic membrane trafficking

The ten eukaryotic COMMD proteins are core components of the Commander complex, with central roles in endosomal membrane trafficking and signalling. Each protein has an α-helical N-terminal (HN) domai...

biorxiv.org

Archaea produce peptidoglycan hydrolases that kill bacteria

Archaea regularly interact with bacteria but reports of archaea killing bacteria are very rare. This study shows that many archaea encode peptidoglycan hydrolases, which specifically target bacterial ...

journals.plos.org

Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1931

royalsocietypublishing.org

The emergence of metabolisms through Earth history and implications for biospheric evolution | Philosophical Transactions of the Royal Society B: Biological Sciences

We investigate the evolution of microbial metabolisms from the last universal common ancestor to the extant biota through comparative phylogenomics, reconciling the evolution of the genes that underpi...

royalsocietypublishing.org

New lease of life: Dead Zoo Lab brings back beloved Natural History Museum collection

Collins Barracks is displaying about 1,300 objects while original Merrion Street location undergoes refurbishment

irishtimes.com

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition | PNAS

The endosomal–lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain c...

pnas.org

Distinct evolutionary trajectories of two integration centres, the central complex and mushroom bodies, across Heliconiini butterflies

Neural circuits have evolved to produce cognitive processes that facilitate a species variable behavioural repertoire. Underlying this variation are evolutionary forces, such as selection, that operat...

biorxiv.org

Pour-over coffee: Mixing by a water jet impinging on a granular bed with avalanche dynamics

Coffee is one of the most consumed beverages in the world. However, issues such as climate change threaten the growth of the temperature-sensitive Coffea arabic

doi.org

IQ-TREE 3: Phylogenomic Inference Software using Complex Evolutionary Models

ecoevorxiv.org

X’s dominance ‘over’ as Bluesky becomes new hub for research

Data indicates more scholars turning to alternative social media site to post about their work after Elon Musk’s Twitter takeover

timeshighereducation.com

A geological timescale for bacterial evolution and oxygen adaptation

Microbial life has dominated Earth’s history but left a sparse fossil record, greatly hindering our understanding of evolution in deep time. However, bacterial metabolism has left signatures in the ge...

science.org

Eukaryotes' closest relatives are internally simple syntrophic archaea

Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...

biorxiv.org

VIBE Research Lab

Viral Informatics, Biostatistics, and Evolution Research Lab at the CVR, University of Glasgow

vibelab.co.uk

ED12442 Research Associate in Phylogenomics (fixed-term) - Jobs at Bath

bath.ac.uk