Huge congratulations to first authors #MachaelaPalor and #TerezaMasonou and to the whole team @uclchildhealth.bsky.social @epicentr.bsky.social and our collaborators. Thank you to families who took part, and to funders #AnimalFreeResearchUK and UKRI/BBSRC

Dr Drew Farr from @epicentr.bsky.social @ucl.ac.uk is talking about how p63 regulates stem cell maintenance and age-associated functional decline in human airway basal cells, at #BALR26

We've launched a new @epicentr.bsky.social lab website! You'll find information about our research, team, publications, and educational resources on airway epithelial biology and regenerative medicine. www.epicentrlab.org

Lizzie Maughan @uclchildhealth.bsky.social led this collaboration with Wenhui Song's lab to develop a bespoke airway stent for use in a 5-month-old with near-complete laryngeal stenosis. The novel 3D-printed stent enabled safe airway reconstruction. 📄 doi.org/10.1002/adfm...

A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction

A programmable interpenetrating double-network architecture, created via 3D-TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural....

doi.org

Our latest work is available on BioRxiv! WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity. www.biorxiv.org/content/10.1...

WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells

Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...

biorxiv.org

Had a wonderful time at the @bsgct.bsky.social annual conference! I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.

Yuki Ishii, @jess0rr.bsky.social Sam Janes, @robhynds.bsky.social @epicentr.bsky.social & team identify Wnt pathway activators as potential pro-regenerative therapies in their compound screen in human airway basal cells. journals.biologists.com/jcs/article/... journals.biologists.com/jcs/article/...

🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social! We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo. doi.org/10.1242/jcs....

Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies

Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.

doi.org

Happy holidays from everyone in the EpiCENTR group! Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁 (h/t scholargoggler.com)

Here's a starter pack that focusses on lung biology, regeneration and cancer. Let me know who I'm missing! go.bsky.app/VC83FZm