Rob Hynds
@robhynds.bsky.social
Scientist studying epithelial biology, stem cells and cancer at UCL (@epicentr.bsky.social) 🫁 Deputy Editor at Stem Cells Translational Medicine
Huge congratulations to first authors #MachaelaPalor and #TerezaMasonou and to the whole team @uclchildhealth.bsky.social @epicentr.bsky.social and our collaborators. Thank you to families who took part, and to funders #AnimalFreeResearchUK and UKRI/BBSRC
We've launched a new @epicentr.bsky.social lab website! You'll find information about our research, team, publications, and educational resources on airway epithelial biology and regenerative medicine. www.epicentrlab.org
EpiCENTR Lab | Airway epithelial stem cells, regeneration, cell and gene therapy
epicentrlab.org
Just over a week to our FIRST event for 2️⃣0️⃣2️⃣6️⃣- 13/01/2026 15:00-17:30 GMT. What better way to fire up those neural circuits than dipping into the latest breaking #Cilia and #Centrosome science 🧪? Free and open to everyone- /1
Mill_lab@cilialab.bsky.social · 7mo agoWe must have been #ExtraNice this year- our #cilia & #centrosome 🧪 community- 🎅 Santa just dropped the 1st session of 2026 line-up @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposia- www.eventbrite.co.uk/e/bscb-genso... See you on the other side! Happy Holidays!
Lizzie Maughan @uclchildhealth.bsky.social led this collaboration with Wenhui Song's lab to develop a bespoke airway stent for use in a 5-month-old with near-complete laryngeal stenosis. The novel 3D-printed stent enabled safe airway reconstruction. 📄 doi.org/10.1002/adfm...
A Bespoke Programmable Interpenetrating Elastomer Network Composite Laryngeal Stent for Expedited Paediatric Laryngotracheal Reconstruction
A programmable interpenetrating double-network architecture, created via 3D-TIPS printing and resin infusion, synergistically combines thermoplastic and thermosetting elastomers to balance structural....
doi.org
Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com
Our latest work is available on BioRxiv! WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity. www.biorxiv.org/content/10.1...
WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells
Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...
biorxiv.org
📣Call for Papers!📣 We aim to showcase work that investigates the underlying mechanisms for lung repair in health and disease, including lung development 📆Deadline: December 31, 2025 🔬Learn More Here: tinyurl.com/ye24jb76 🖱️Submit here: tinyurl.com/yahzwj8k @atscommunity.bsky.social #medsky
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals. ✅ Wet & dry lab ✅ September 2025 enrolment ✅ UK tuition fees only www.ucl.ac.uk/medical-scie...
Pre-Cancer Immunology
The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.
ucl.ac.uk
The AJRCMB Call for Papers on Lung Repair Models and Mechanisms - launched at the Vermont Stem Cell Conference earlier this month - is now open! Please consider submitting your next paper here. Thanks to Janette Burgess and Andrew Halayko for making this happen 🙌
It was an honour to co-chair the 20th Anniversary Vermont Lung Stem Cell Conference in Vermont last week. Grateful to Amy Ryan, @skocguen.bsky.social & Dan Weiss, our planning teams, and everyone who joined us. Excited to return to Burlington in 2027!
Great to see Krijn’s work from @crick.ac.uk published! He developed clonal organoid lines from NSCLC tumours and PDX models. Immune evasion varied between clones from the same tumour, highlighting intratumour heterogeneity and providing a model to study it.
Cancer Cell@cp-cancercell.bsky.social · last yr.Online Now: Subclonal immune evasion in non-small cell lung cancer
Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit. www.science.org/doi/10.1126/...
A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.
science.org
Had a wonderful time at the @bsgct.bsky.social annual conference! I was delighted to be able to share our work on human airway epithelial cell culture for transplantation and how this contributes to the @epicentr.bsky.social efforts towards a cell and gene therapy for airway epidermolysis bullosa.
Great to see so many familiar faces registered for the 20th Anniversary Stem Cells, Cell Therapies & Bioengineering Conference in Burlington in July. There’s still time to register and for trainees to book a spot on the unique pre-conference workshops. t.co/vbsFFhaeAZ
This is quite amazing, the team identified some exceptionally powerful neutralizing antivenom antibodies and are working toward a universally protective cocktail. Brilliant, and all it took was for a single person to get bitten by snakes some 200 times.... www.cell.com/cell/fulltex...
Snake venom protection by a cocktail of varespladib and broadly neutralizing human antibodies
To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a combination of two of the identifie...
cell.com
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social! We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo. doi.org/10.1242/jcs....
Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.
doi.org
A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...
Remembering David Stephens (1971–2024)
In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...
journals.biologists.com
Don't forget to secure your place and submit your abstract for the LSCN 8th Annual Symposium! 🔗Registration: eventbrite.co.uk/e/8th-annual... Website: lscn.co.uk (where the final agenda will be published soon) Abstract submission (deadline 04/04!) docs.google.com/forms/d/e/1F...
LSCN Members can access a code for free registration! Become a member by registering on our website lscn.co.uk and find the free code on the symposium page!
Home - London Stem Cell Network
lscn.co.uk
Ras inhibition in CAFs reduces their activation and decreases tumor burden. Awesome new work from collaborator Esther Castellano's team 👏
bioRxiv Cancer Bio@biorxiv-cancer.bsky.social · 2y agoRAS-PI3K Pathway in CAFs Shapes Physicochemical Properties of Tumor ECM and restrains Tumor progression https://www.biorxiv.org/content/10.1101/2025.01.20.633776v1
Happy holidays from everyone in the EpiCENTR group! Follow @jess0rr.bsky.social and @drewfarr.bsky.social for our latest throughout 2025 🎁 (h/t scholargoggler.com)
This radiotracer can distinguish high/low NRF2 antioxidant pathway activation, including in our TRACERx lung cancer PDX models! Great to see the manuscript out, congrats Tim and team! 👏
Tim Witney@timwitney.bsky.social · 2y ago🚨Out today in @natureportfolio.bsky.social Nature Communications: Imaging NRF2 activation in non-small cell lung cancer with positron emission tomography🍾 www.nature.com/articles/s41... In this paper, we show that [18F]FSPG-PET imaging is a sensitive marker of NRF2/KEAP1 activating mutations...
Early bird registration ends 20th Dec - register early!
Rob Hynds@robhynds.bsky.social · 2y agoRegistration for the 20th Anniversary Vermont Lung Stem Cells meeting is open! 🌟 Hands on bioinformatics or lab techniques workshops. 🌟 Great speakers including @kottond.bsky.social, @tatalab-duke.bsky.social & many others not yet here! 📅 7-10th July 2025 📍 Burlington, VT 🕸️ go.uvm.edu/stem25
Early bird registration ends 20th Dec - register early!
Rob Hynds@robhynds.bsky.social · 2y agoRegistration for the 20th Anniversary Vermont Lung Stem Cells meeting is open! 🌟 Hands on bioinformatics or lab techniques workshops. 🌟 Great speakers including @kottond.bsky.social, @tatalab-duke.bsky.social & many others not yet here! 📅 7-10th July 2025 📍 Burlington, VT 🕸️ go.uvm.edu/stem25
We're hiring a postdoc! Please forward to people you know who are looking for positions. Interested in studying how metabolism is wired to support fertility? 🔬🪰 Come join us! Ad to go live next week, but informal enquiries encouraged.
Our TRACERx lung cancer patient-derived-xenograft (PDX) models are now available to the research community at CancerTools.org! 🎉 Huge thanks to Dave Pearce, @charlesswanton.bsky.social and the brilliant CRUK LCCE team who have made this possible. Find out more here: cancertools.org/nsclc-pdx-mo...
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CancerTools.org is part of Cancer Research UK. Discover a global, non-profit, cancer research tools biorepository
cancertools.org
Here's a starter pack that focusses on lung biology, regeneration and cancer. Let me know who I'm missing! go.bsky.app/VC83FZm
Registration for the 20th Anniversary Vermont Lung Stem Cells meeting is open! 🌟 Hands on bioinformatics or lab techniques workshops. 🌟 Great speakers including @kottond.bsky.social, @tatalab-duke.bsky.social & many others not yet here! 📅 7-10th July 2025 📍 Burlington, VT 🕸️ go.uvm.edu/stem25
