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@epicentre-msf.bsky.social

Epidemiology, medical research, innovation and training group embedded in Medecins Sans Frontieres. Design & carry out projects in complex and unstable settings

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@epicentre-msf.bsky.social · yesterday

At Al-Salam Hospital, Yemen, neonatal mortality was strongly linked to very low birth weight, prematurity, and birth asphyxia. ▶️need to strengthen maternal care, neonatal resuscitation, Kangaroo Mother Care, and antibiotic stewardship link.springer.com/article/10.1...

Clinical characteristics and in-hospital mortality outcomes of admitted neonates at the MSF-supported Al-Salam MOH Hospital, Amran Governorate, Yemen: A retrospective descriptive analysis - BMC Pediat...

Background Globally, about 2.3 million neonates die annually, most of them in low-resource and conflict-affected countries. In Yemen, ongoing humanitarian crises put children at continued risk, with n...

link.springer.com

@epicentre-msf.bsky.social · 6d ago

Could existing Ebola vaccines help respond to the current Bundibugyo outbreak in the DRC? A new @thelancetinfdis.bsky.social commentary suggests that deploying Ervebo in high-risk groups could provide protection while generating crucial evidence for future outbreaks www.thelancet.com/journals/lan...

Reconsidering the rVSVΔG-ZEBOV-GP vaccine during the 2026 Bundibugyo virus outbreak

The ongoing 2026 Bundibugyo virus disease (BVD) public health emergency of international concern in DR Congo and Uganda has exposed gaps in preparedness for non-zairense orthoebolaviruses. With BVD va...

thelancet.com

@epicentre-msf.bsky.social · 2w ago

Ebola in the DRC: data driving action. Epicentre’s epidemiologists are working alongside MSF teams to monitor the outbreak in real time and help guide the response on the ground. epicentre.msf.org/en/news/moni...

Monitoring, understanding, responding, and learning from past epidemics: the key role of the epidemiologist in the face of Ebola

On May 15, the Democratic Republic of the Congo (DRC) declared its 17th Ebola virus disease outbreak, caused by the Bundibugyo virus, for which there is currently no vaccine or specific treatment. In ...

epicentre.msf.org

@epicentre-msf.bsky.social · 2w ago

With a new Ebola outbreak in DRC, lessons from the 2018-2020 epidemic remain relevant. Our preprint shows that prolonged community exposure before detection drives transmission. Priorities: earlier detection, decentralized care, active contact tracing & vaccination www.medrxiv.org/content/10.6...

Quantifying the heterogeneity and determinants of Ebola Zaïre transmission during the 10th outbreak in DRC, 2018 – 2020

Background The 2018–20 Ebola virus disease outbreak in the Democratic Republic of the Congo (DRC) was the country’s largest, and the second largest globally, amid armed conflict and community mistrust...

medrxiv.org

@epicentre-msf.bsky.social · 4w ago

A new milestone for the R21 malaria vaccine trial in Chad: the booster dose phase is now complete. Together with studies in Burkina Faso and Mali, the trial is evaluating the best strategy to maximize protection for children under 5. epicentre.msf.org/en/news/mala...

Malaria: vaccines, hope and many challenges

While the first malaria vaccines, RTS,S/AS01and R21/Matrix-M™, mark a major step forward in the fight against this disease, questions remain about the best administration strategy to maximize their im...

epicentre.msf.org

@epicentre-msf.bsky.social · 4w ago

What can we learn from a large measles outbreak in DRC? insights into a large measles outbreak in Yakusu health zone, DRC (Jan 2018– June 2019) link.springer.com/article/10.1...

Measles epidemic in Yakusu Health Zone, Democratic Republic of Congo, 2018–2019: a retrospective observational study - BMC Infectious Diseases

Background A large measles outbreak occurred in Yakusu Health Zone, Democratic Republic of the Congo, between January 2018 and June 2019. We aimed to estimate the magnitude, mortality burden, and vacc...

link.springer.com

@epicentre-msf.bsky.social · last mo.

ENABLE 1.0 followed 20,000+ people across 4 West African countries, generating crucial evidence on Lassa fever incidence and outcomes. Findings will help guide future vaccine trials and strengthen community fever management. pubmed.ncbi.nlm.nih.gov/42379202/

Incidence of symptomatic Lassa virus infection in West African countries (Enable 1.0 Lassa Research Study): a prospective, multisite, cohort study - PubMed

The Coalition for Epidemic Preparedness Innovations.

pubmed.ncbi.nlm.nih.gov

@epicentre-msf.bsky.social · last mo.

Pediatric Early Warning System (PEWS) scores help detect hospitalized children at risk but what about those with SAM in low-resource settings? 👉An adapted PEWS score can predict adverse outcomes in children with complicated SAM. publications.aap.org/pediatrics/a...

Performance of a Pediatric Early Warning Score Among Children With Severe Acute Malnutrition

10.1542/6388819904112Video AbstractPEDS-VA_2025-0723576388819904112OBJECTIVES. Pediatric Early Warning Systems (PEWSs) have been used to predict adverse outcomes among hospitalized patients, though ev...

publications.aap.org

@epicentre-msf.bsky.social · 2mo ago

[World #SickleCellDisease Day] 80% of people living with SCD are in sub-Saharan Africa. Hydroxyurea is effective, but access remains limited. With #MSF, Epicentre studies in Niger & Uganda aim to scale up access and adapt care. epicentre.msf.org/en/news/sick...

Sickle cell disease: documenting and improving acess to hydroxyurea in sub-Saharan Africa

Despite its proven effectiveness, hydroxyurea remains difficult to access and underused in sub-Saharan Africa. Two studies conducted by Epicentre and Médecins Sans Frontières (MSF) aim to document the...

epicentre.msf.org

@epicentre-msf.bsky.social · 2mo ago

#JS2026 Why mortality studies matter for MSF and beyond: • Independent data collection • Better resource allocation • Stronger communication & advocacy • Legal evidence 👉 Essential for informed and accountable action.

Bild
@epicentre-msf.bsky.social · 2mo ago

#JS2026 Good news amid cholera vaccine shortages: Two-dose OCV schedules spaced at 6 or 12 months are immunologically non-inferior to the standard 2-week interval against V. cholerae O1. 👉 More flexibility, without compromising long-term immunity.

Bild
@epicentre-msf.bsky.social · 2mo ago

#JS2026 The data from 10th Ebola outbreak in the DRC (2018–2020) revealed a striking story: a small minority of cases (~18%) were responsible for 80% of all infections. Isolation, contact follow-up, and ring vaccination all demonstrably cut transmission when they could be applied.

Bild
@epicentre-msf.bsky.social · 2mo ago

A systematic review and meta-analysis comparing IV and oral rehydration strategies in children with SAM and severe dehydration. ➡️no clear difference in mortality between the two approaches, although IV rehydration was associated with fewer adverse events. adc.bmj.com/content/earl...

@epicentre-msf.bsky.social · 2mo ago

Epicentre's Scientific Day is coming up - June 4 Join us for a unique opportunity to explore the full diversity of our work: 🔬 diseases and medical focus areas 📊 methodologies 🌍 countries Paris or online Program, registration 👉https://epicentre.msf.org/en/scientific-days/scientific-day-2026

@epicentre-msf.bsky.social · 3mo ago

Declared May 15, 2026 in NE DRC, this outbreak is driven by a poorly documented virus, Bundibugyo, with late detection, no specific diagnostics, and no approved vaccine or treatment — in a conflict-affected setting. epicentre.msf.org/en/news/bund...

The Bundibugyo virus challenge: why is this Ebola disease outbreak different?

On May 15, 2026, the Democratic Republic of Congo's Ministry of Health officially declared an Ebola disease outbreak in the northeast of the country, where Médecins Sans Frontières (MSF) teams are ope...

epicentre.msf.org

@epicentre-msf.bsky.social · 4mo ago

New findings from the AMOCO study highlight major barriers faced by women hospitalized with severe abortion complications in Bangui, Central African Republic. Urgent action needed to improve timely, high quality postabortion care. link.springer.com/article/10.1...

Pathways to care among women hospitalized with severe abortion complications in Bangui, Central African Republic, a conflict-affected urban setting: qualitative results of the AMoCo (abortion-related ...

Background The Central African Republic (CAR), a fragile and conflict-affected setting, has one of the highest maternal mortality ratios in the world. Complications of unsafe abortion, while preventab...

link.springer.com

@epicentre-msf.bsky.social · 4mo ago

A strong illustration of the importance of highly collaborative efforts and multicountry solutions to cholera control. Coordinated genomic surveillance can uncover cross border transmission and critical shifts in the bacterial genome. www.nature.com/articles/s41...

Multicountry genomic analysis underscores regional cholera spread in Africa - Nature Communications

Cholera remains a significant public health burden in sub-Saharan Africa, but the mechanisms of continental and regional spread remain undefined. Here, the authors investigate recent patterns of spread using Vibrio cholerae genomic surveillance data collected by a consortium of seven African Union member states from 2019-2024.

nature.com

@epicentre-msf.bsky.social · 4mo ago

New shorter, all oral MDR/RR TB regimens work in trials, but how do they work in real life? A study in Pakistan looks at feasibility, acceptability and impact of MDR/RR TB treatments beyond controlled settings, including for children and pregnant women. epicentre.msf.org/en/news/tube...

Tuberculosis: Documenting the transition to shorter treatments for multidrug-resistant TB under real-life conditions

In Pakistan, Epicentre is conducting a study to better understand how new, all oral, shorter treatments for multidrug-resistant/rifampicin‑resistant tuberculosis (MDR/RR-TB) are implemented in real-world settings. These treatment regimens have already proven effectiveness in clinical trials, and are recommended by the World Health Organisation (WHO), but what about once they leave the controlled setting of a trial? The study explores their impact on patients' lives, their feasibility for healthcare providers, and their acceptability in a context where challenges remain numerous: treating children and pregnant women, managing highly resistant forms of TB, and monitoring the emergence of new resistance.

epicentre.msf.org

@epicentre-msf.bsky.social · 4mo ago

Most HIV programmes kept ART initiations stable during the 1st year of COVID 19 — a sign of resilience. But declines in some settings show the need to understand what sustained ART under strict measures so we can be better prepared. bmjopen.bmj.com/content/16/3...

Effect of COVID-19 pandemic on ART access and timely initiation in people living with HIV in 31 countries: a regression discontinuity design study

Objectives The COVID-19 pandemic threatened global HIV Test and Treat Efforts. We assessed whether it affected (1) the number of antiretroviral therapy (ART) initiations and (2) the proportion of time...

bmjopen.bmj.com