"We are living with the legacy of the McCarthy era, and what Donald Trump is doing is really resurrecting the worst."⁠ ⁠ After a performance of "Are You Now Or Have You Ever Been," @dlnyclu.bsky.social spoke at a talkback on the attacks we're enduring on free speech and the fight for our democracy.⁠

Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion. www.biorxiv.org/content/10.6...

Absolutely beautiful paper by a core team at the RIKEN in which the telomerase RNA component has (finally) been identified, in the nematode *C. elegans*. Surprisingly, it does not have its own promoter, but is located inside the intron of a germline-expressed gene (nmy-2)! 🤩 doi.org/10.1126/scie...

Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes

Telomerase is a ribonucleoprotein complex that elongates telomeric DNA, ensuring germline immortality. In this study, we identified the Caenorhabditis elegans telomerase RNA component 1 (terc-1), as t...

doi.org

Really cool paper from Marie-Anne Felix's lab. Genetic variation in set-24 controls the duration of epigenetic inheritance. www.cell.com/current-biol...

Intraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegans

Frejacques, Saglio, et al. demonstrate variation among C. elegans wild isolates in the multigenerational memory of an initial RNA interference trigger. Genetic polymorphisms and environmental variable...

cell.com

#DBfeature VEGF signalling promotes blastema growth and proliferation of both vascular and non-vascular cells during axolotl limb regeneration By Aaron Savage et al. tinyurl.com/3xs4nffs

Excited to share our new work on transgenerational adaptation www.science.org/doi/epdf/10.... out today spearheaded by outstanding former undergraduate @kathleenkim.bsky.social. C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content, + longevity 1/9

MADELEINE DEAN: The president is unhinged. He's unwell JOHNSON: A lot of folks on your side are too D: Oh my god, please. That performance in front of the generals? J: I didn't see it D: It's so dangerous! Our allies are looking elsewhere. Our enemies are laughing. You have a POTUS who's unwell.

www.science.org/doi/10.1126/...

Lysosomes signal through the epigenome to regulate longevity across generations

The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways sig...

science.org

Just talked with my wife, we are cancelling our Disney+ subscription. If you have one, I encourage you to do the same.

A federal judge in Boston said she found it "difficult to conclude anything other than that [the Trump administration] used antisemitism as a smokescreen for a targeted, ideologically-motivated assault on this country's premier universities, and did so in a way that runs afoul of [federal law]."

Trump administration illegally froze billions in Harvard funds, judge rules

The ruling is a legal victory for Harvard but the White House says it will appeal the decision.

n.pr

Donna Lieberman of @nyclu.org is absolutely right. It's vital that @governor.ny.gov sign these critical bills to protect New Yorkers' reproductive freedom, including the NY Health Information Privacy Act that I carry w/@lindabrosenthal.bsky.social. www.timesunion.com/opinion/arti...

Commentary: Hochul must sign bills that protect access to reproductive care

As threats mount nationwide, New York must do all it can to ensure everyone can get the care they need.

timesunion.com

Trump: "A lot of people are saying maybe we'd like a dictator."

This is literally some of the craziest shit I have ever read. And that's saying a lot. www.whitehouse.gov/presidential...

Improving Oversight of Federal Grantmaking

By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

whitehouse.gov

A little known - but hugely consequential - part of the government’s changes to science funding: open.substack.com/pub/sciencea...

A Quiet Policy Shift That Could Devastate American Science

Why NIH’s sudden move to multi-year grant funding should alarm every principal investigator and university

open.substack.com

Excited to see our manuscript out @natcomms.nature.com pubmed.ncbi.nlm.nih.gov/40721431/. We identified that the 18S rRNA methylase DIMT-1 regulates lifespan by functioning in the germline after midlife. 1/8

The 18S rRNA methyltransferase DIMT-1 regulates lifespan in the germline later in life - PubMed

Specialized ribosomes help determine which proteins are synthesized, however, the influence of age on ribosome heterogeneity and whether dysregulation of this process drives organismal aging is unknow...

pubmed.ncbi.nlm.nih.gov

I was born in the McCarthy era, but this is McCarthyism on steroids. Our democracy is under dire threat. But we have a government of laws, not men. And NO ONE is above the law.

NYCLU@nyclu.org · last yr.

Across the country, the ACLU has already filed more than 50 lawsuits to defend free speech, due process, equal rights, and the rule of law. We’ve got the assignment. And we’re not slowing down. @dlnyclu.bsky.social 📍Foley Square

Congratulations to Anne @brunetlab.bsky.social for being elected to the AAAS www.amacad.org/new-members-...! And congratulations to all the other new members

New Academy Members

Elected in 2025

amacad.org

New WormBook Chapter: Chromatin and epigenetics in aging biology academic.oup.com/genetics/adv...

Chromatin and epigenetics in aging biology

Abstract. This book chapter will focus on modifications to chromatin itself, how chromatin modifications are regulated, and how these modifications are dec

academic.oup.com

Last week, House Democrats opposed giving Elon Musk and Trump a blank check funding bill that would allow them to gut programs and services families rely on. The Senate must pass a short-term spending bill so we can pass bipartisan bills that protect programs for our communities.

They literally just told everyone in the dept of education to not come to work!!! They are already doing this!!!

KEEP CALLING. PEEL OFF ALL DEM SENATORS YOU CAN. ☎️: (202) 224-3121 Tell them to vote NO on Cloture and NO on CR. Vote is pushed to after 1:15ish for now. Situation is fluid. The only public YES votes are Schumer and Fetterman. They need 7-8 total. KEEP CALLING. Call retiring Senators too!

CALLS ARE WORKING - it has bought us precious time, but we NEED to keep the pressure up. Tomorrow is the cloture vote. KEEP CALLING: (202) 224-3121 ☎️☎️☎️ Tell your Dem Senator to vote NO on Cloture and NO on the Republican spending bill. Do NOT assume your Senator will be good on this. Trust me.

Alexandria Ocasio-Cortez@aoc.bsky.social · last yr.

🚨 Everyone needs to call their Dem Senator right now. They are starting to cave. Tell them: 1. Vote NO on Cloture AND 2. Vote NO on the Republican spending bill. Don’t let them pivot to reconciliation. GOP doesn’t need Dem votes on that and they know it. TODAY is the showdown. 🤳🏽: (202) 224-3121

Donna Lieberman, @dlnyclu.bsky.social Executive Director of the New York Civil Liberties Union @nyclu.org on Mahmoud Khalil: "There is not a hint of a claim that he did any of those things. The idea that he should be deported is illegal, wrong, and reeks of McCarthyism."

go.bsky.app/QkSL6S5