New review out in Chem Rev: "Navigating Misfolded Terrain: ER-Associated Degradation of Membrane Proteins." We loved pulling together the whole story of ERAD, from the discovery of ubiquitin to today's cryo-EM structures of ERAD machineries. (1/3) doi.org/10.1021/acs....
Navigating Misfolded Terrain: ER-Associated Degradation of Membrane Proteins
Integral membrane proteins face unique folding challenges in the endoplasmic reticulum (ER) due to their hydrophobic transmembrane domains and complex topologies. Membrane protein misfolding disrupts ...
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