Siobhan Mitchell, PhD
@esiobhanmitchell.bsky.social
I'm a neuroscientist with a special focus on nutrition, metabolism and mitochondria. Always happy to chat about brain aging (or any kind of aging), great books to read, travel, food and writing. https://scholar.google.com/citations?user=s6LruaUAAAAJ&hl=en
Gladstone et al (2026): "biographies of female scientists disproportionately emphasized effort even after adjusting for the obstacles they faced, consistent with stereotypes attributing women’s success to hard work over talent." 🧪 #psychscisky
Proceedings of the National Academy of Sciences@pnas.org · 6d agoOne of the most-viewed PNAS articles in the last week is ”Children’s books about scientists convey demotivating messages.” Explore the article here: https://ow.ly/oTon50ZuLj3 For more trending articles, visit https://ow.ly/TsjY50ZuLj2.
Hormonal replacement therapy is linked to better cognition (especially language fluency, so if you find yourself forgetting words this might help)🧪 pubmed.ncbi.nlm.nih.gov/42366122/
Hormone Therapy is Associated with Better Cognitive Performance in Postmenopausal Women: Insights from the National Health and Nutrition Examination Survey (NHANES) - PubMed
There is a positive association between hormone therapy and cognitive performance in postmenopausal women, particularly in age groups with the steeper decline. In addition, there is no significant ass...
pubmed.ncbi.nlm.nih.gov
Carmen Sandi is an inspiration - This is a really excellent article - essential reading for anyone interested in mitochondria within the central nervous system. www.nature.com/articles/s41...
Brain mitochondria as key drivers of cognition and behaviour - Nature Reviews Neuroscience
Neuronal and glial mitochondria support neuronal circuit function and plasticity through the supply of energetic substrates and the regulation of cellular physiology. Sandi and colleagues describe how...
nature.com
Stress resilience helps keep metabolic health intact, while stress-prone personalities sustain more damage from high fat intake www.nature.com/articles/s41...
Stress-coping phenotypes shape adipose tissue function and plasticity and modulate metabolic resilience - Translational Psychiatry
Translational Psychiatry - Stress-coping phenotypes shape adipose tissue function and plasticity and modulate metabolic resilience
nature.com
Wildfire smoke is getting worse every year. Studies show exposure can cause mitochondria dysfunction antioxidants that protect mitochondria can help in preclinical models🧪 www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...
New epsiode on how to prime your mitochondria for more energy, cognition and healthy aging with Daphne Bascom MD, PhD 🧪 Thrive on Plants podcast episode: Apple Podcasts: podcasts.apple.com/us/podcast/5... YouTube: youtu.be/XBQoEXTxvRU?...
This link will take you to a page that’s not on LinkedIn
lnkd.in
Eight Weeks of MitoQ Supplementation Does Not Alter Kidney Function or Urinary Kidney Injury Biomarkers in Middle-Aged and Older Adults American Journal of Physiology-Renal Physiology | American Physiological Society journals.physiology.org/doi/abs/10.1...
Eight Weeks of MitoQ Supplementation Does Not Alter Kidney Function or Urinary Kidney Injury Biomarkers in Middle-Aged and Older Adults | American Journal of Physiology-Renal Physiology | American Phy...
Introduction: Several human trials have used the mitochondrial antioxidant mitoquinol mesylate (MitoQ). There are no apparent negative consequences on the kidneys following an acute high dose of MitoQ...
journals.physiology.org
Episode 2 of the MitoPod is live - this time diving into GLP-1s and what they're really doing to your mitochondria, featuring Dr. Siobhan Mitchell @esiobhanmitchell.bsky.social ▶️ youtu.be/3Lm6C_mLOM4 🎧 open.spotify.com/episode/7vu8... 🔬 mitoquinol.org
GLP-1s and Mitochondrial Function | Dr. Siobhan Mitchell
YouTube video by MitoPod
youtu.be
New study shows that taking 2g of DHA for 2 years had no effect on memory or brain health of older subjects. However, I wonder why they didn't add EPA to the treatment, which is better at decreasing brain inflammation 🧪 www.thelancet.com/journals/EBI...
CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial
High-dose DHA achieved CNS target engagement in non-demented older adults with low baseline omega-3 intake, independent of APOE ε4. Despite biochemical target engagement, no differences in cognition o...
thelancet.com
a new mitochondria focused podcast just debuted, and talks about practical ways to improve mitoquinol health such as heat exposure (sauna), exercise, n-acetylcysteine, omega-3 oils, mitocohndria uncouplers 🧪
@mito-research.bsky.social · 2mo agoWe've launched the MitoPod - a podcast translating mitochondrial science for researchers, clinicians and the curious. Episode 1 is live featuring Dr. Siobhan Mitchell @esiobhanmitchell.bsky.social ▶️ www.youtube.com/watch?v=vG2h... 🎧 open.spotify.com/episode/7Lal... 🔬 mitoquinol.org
Exciting study shows that as we age our #mitochondria membrane loses key lipids like #phosphatidylcholine Supplementation of phosphatidylcholine (found in soy) rescued mitochondria energy production 🧪 www.nature.com/articles/s41...
Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging - Nature Communications
Mitochondrial decline impairs late-life metabolic plasticity. Using nematodes and human data, this study identifies reduced phosphatidylcholine synthesis as a natural trigger of mitochondrial dysfunct...
nature.com
Thank you @nature.com for highlighting the voice of a researcher being #cancelled by the #longevity field! www.nature.com/articles/d41... "Saul Newman at Oxford Institute of Population Ageing, UK, sought to debunk the concept of ‘blue zones'" No #aging #journal is brave to publish his paper!!!
How long can humans live? We simply don’t know
Claims about the upper limits to human lifespan are characterized by hype, deficient data and shoddy science, says longevity researcher Saul Newman.
nature.com
A #mitochondria intervention that may help mood. In a study I co-authored with Carmen Sandi, we showed augmenting mitochondria function in the cortex and amygdala using medium chain triglycerides had benefits for anxiety 🧪 www.sciencedirect.com/science/arti...
Medium chain triglyceride diet reduces anxiety-like behaviors and enhances social competitiveness in rats
Medium-chain triglycerides (MCT) are emerging as unique dietary supplements that are potentially relevant for the amelioration of brain dysfunctions. …
sciencedirect.com
Sore muscles may slow more than movement. New research in the Journal of Neurophysiology suggests post-workout soreness can briefly make the brain work harder to track body position & plan movement: https://ow.ly/c2Mb50Z2rbI APS Publications #ArticlesInPress #ExerciseScience 🧪 📷: iStock
Classifying ovaries solely as #reproductive organs has obscured their role as systemic regulators of female physiology. @jennifergarrison.bsky.social contends that ovarian #aging is a primary determinant of healthspan and belongs at the center of geroscience. 🧪
Beyond reproduction: The ovary as a systemic regulator of female health and aging
Classifying ovaries solely as reproductive organs has obscured their role as systemic regulators of female physiology. This Perspective discusses that ovarian aging is a primary determinant of…
plos.io
Mice treated with dasatinib + quercetin lost high amounts of myelin, mimicking multiple sclerosis pathology 🧪 www.pnas.org/doi/10.1073/...
Popular anti-aging drug combo caused severe brain damage in mice
A drug combo widely explored for anti-aging may actually damage the brain, according to new mouse research showing severe loss of myelin and changes linked to “chemo brain.” Surprisingly, the damaged ...
sciencedaily.com
Deep breathing can help with HRV and emotions, but not memory! Slow paced breathing can improve heart rate variability (HRV) and emotional resilience (eg less negative focus) but can worsen memory recall in young adults 🧪 www.sciencedirect.com/science/arti...
Breathing slower is not always better: Slow-paced breathing enhances heart rate variability but produces age-differential effects on emotional reactivity and memory
Slow-paced breathing (SPB) is commonly used to promote autonomic regulation and emotion regulation, but its effects on emotional memory, and whether t…
sciencedirect.com
#Fisetin treatment improves vascular health and suppresses cellular senescence in older adults via #mitochondria 🧪 journals.physiology.org/doi/abs/10.1...
Intermittent fisetin treatment improves vascular endothelial function and suppresses cellular senescence in older adults: role of reduced mitochondria-related oxidative stress | Physiology | American ...
Background: Vascular endothelial dysfunction is a key antecedent to cardiovascular diseases (CVD) in older adults. Reduced nitric oxide (NO) bioavailability secondary to excess mitochondria-related re...
journals.physiology.org
Senescent (etoposide) C2C12 myoblasts are mTORC1-hyperactive & Susceptible to cell death upon MitoQ (not NAC) treatment So, mitochondrial ROS scavenger as a new #Senolytic ?😀 Want to see in vivo effect! Will rapamycin⬆️senescent myogenic cells in vivo?🤔 bioRxiv 2026 www.biorxiv.org/content/10.6...
New study: Mitochondrial DNA nucleoids are distributed by a process called "pearling". This transforms mitochondria into bead-like forms, impacting function. PMID:41926598, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adu5646 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://doi.org/10.1126/science.adu5646
No description available
doi.org
🧪anti-amyloid antibodies (like those approved for Alzheimer's) shown to vascular damage in mice expressing APOE4 Another reason to be wary of the supposedly therapeutic #Alzheimer's antibodies currently approved by the #FDA www.biorxiv.org/content/10.6...
biorxiv.org
A multiyear effort to rename polycystic ovary syndrome finally revealed the condition’s new name: polyendocrine metabolic ovarian syndrome
PCOS just got a new name—here’s what to know
A multiyear effort to rename polycystic ovary syndrome finally revealed the condition’s new name: polyendocrine metabolic ovarian syndrome
scientificamerican.com
🧪Gene transfer from long-lived mole rats improves lifespan of mice. A hyaluronic acid gene (which helps make more high molecular weight hyaluronic acid) prevents inflammation and tumor formation in mole rats, and this protective gene helped mice live longer. www.nature.com/articles/s41...
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice - Nature
Mice overexpressing Has2 from the naked mole-rat showed an increase in hyaluronan levels in several tissues, and a lower incidence of spontaneous and induced cancer, attenuated inflammation through se...
nature.com
Why does your body stop responding the same way at midlife? I joined Dr. Mariza Snyder’s Podcast to unpack what’s happening at the metabolic and cellular level during perimenopause and menopause. We explore how declining estrogen reshapes metabolism+ mitochondria 🧪 drmariza.com/episode741
741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel
So many women feel like their body has suddenly turned against them—weight gain, fatigue, brain fog, and rising inflammation—despite doing all the right things. But this isn’t a failure of effort. It’...
drmariza.com
🧪Your immune system is dependent on healthy mitochondria potential. T-cells, which fight infections+tumours, need to have proper electron flow. When we age this becomes compromised, increases likelihood of illness. Mitochondria antioxidants can support electron flow. www.cell.com/cell-metabol...
Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells
How metabolism shapes dendritic cell (DC) immunogenicity is debated—while glycolysis activates, OXPHOS implies tolerance. Heras-Murillo et al. find that ETC electron flow primes cDC1s via redox/metabo...
cell.com
🧪Ketones improve cognition and glycemic control in young adults The Effects of 31-Day Exogenous Ketone Consumption on Running Performance, Cognitive Function, Metabolism, Body Composition, Hemodynamics, and Mood in Recreational Runners: A Randomized-Control Trial www.tandfonline.com/doi/full/10....
The Effects of 31-Day Exogenous Ketone Consumption on Running Performance, Cognitive Function, Metabolism, Body Composition, Hemodynamics, and Mood in Recreational Runners: A Randomized-Control Trial
Exogenous ketone supplementation acutely elevates circulating beta-hydroxybutyrate (R-BHB), but the impact of chronic repeated dosing on exercise performance, cognition, mood, and cardiometabolic h...
tandfonline.com
🧪A common clinical lab result, Red Cell Distribution Width (RDW) may be a biomarker for mitochondria function and risk of physical, cognitive decline Increased RDW was associated with worse physical performance, less maximal ATP production Time to check yours? pubmed.ncbi.nlm.nih.gov/41950902/
Associations of Elevated Red Cell Distribution Width (RDW) with Decreased Physical and Cognitive Function in Older Adults, and The Potential Mediation by Mitochondrial Energetics: The Study of Muscle,...
We analyzed the association between RDW and skeletal muscle mitochondrial energetics and how skeletal muscle mitochondrial energetics may mediate the associations of RDW with physical and cognitive pe...
pubmed.ncbi.nlm.nih.gov