Eunus S. Ali, Ph.D.
@eunusali.bsky.social
Assistant Professor at University of Kentucky College of Medicine. http://eal-metabolab.com. Ex-postdoc (@bensahralab) at Northwestern, Metabolism and signaling lover. Writer. Stockholm alum. ORCID: https://orcid.org/0000-0002-9477-3500
Huge Congratulations to Dr. Liu team, James, all the members involved. Glad to contribute to a bit to this beautiful work. This study unravels that PLK1 phosphorylates PHGDH, decreases de novo serine biosynthesis but promotes sphingolipid production. pubmed.ncbi.nlm.nih.gov/42507939/
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Ca2+ Imaging in H4IIE Liver Cells and Primary Rodent Hepatocytes: A Cost-Effective Protocol for Use With Fura-2 AM Ca<sup>2+</sup> Indicator bio-protocol.org/en/bpdetail?...
bio-protocol.org
Impaired Ca2+ signaling due to hepatic steatosis mediates hepatic insulin resistance in Alström syndrome mice that is reversed by GLP-1 analog treatment | American Journal of Physiology-Cell Physiology | American Physiological Society journals.physiology.org/doi/full/10....
Impaired Ca2+ signaling due to hepatic steatosis mediates hepatic insulin resistance in Alström syndrome mice that is reversed by GLP-1 analog treatment | American Journal of Physiology-Cell Physiolog...
Ca2+ signaling plays a critical role in the regulation of hepatic metabolism by hormones including insulin. Changes in cytoplasmic Ca2+ regulate synthesis and posttranslational modification of key sig...
journals.physiology.org
Calcium Imaging in H4IIE Liver Cells and Primary Rodent Hepatocytes: A Cost-Effective Protocol for Use With Fura-2 AM Ca2+ Indicator bio-protocol.org/en/bpdetail?...
bio-protocol.org
We rewrote why and how calcium signaling is a critical player in fatty liver disease: www.sciencedirect.com/science/arti...
Calcium Signaling As a Therapeutic Target for Liver Steatosis
Hepatic steatosis, the first step in nonalcoholic fatty liver disease (NAFLD), can arise from various pathophysiological conditions. While lipid metab…
sciencedirect.com
Congratulations Marlee ! All of EAL-Lab are proud of your achievement and making in the news ! medicine.uky.edu/news/5-colle...
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
nature.com
Huge CONGRATULATIONS to Ram, Nav and the whole team! Extremely glad to see it as a published form !! www.nature.com/articles/s41...
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
nature.com
Calcium Signaling As a Therapeutic Target for Liver Steatosis: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
Calcium Signaling As a Therapeutic Target for Liver Steatosis
Hepatic steatosis, the first step in nonalcoholic fatty liver disease (NAFLD), can arise from various pathophysiological conditions. While lipid metabolism in the liver is normally balanced such that ...
cell.com
Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation: Molecular Cell www.cell.com/molecular-ce...
Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation
Qin et al. show that the pyrimidine synthesis enzyme CAD reprograms central carbon metabolism by deamidating G6PD and PHGDH, thereby fueling the formation of tumors, including hepatocarcinoma. Targeti...
cell.com
Distinct subtype of mito !! >> ETC complex III function is necessary for the formation of endoplasmic reticulum and mitochondria contact sites (ERMCSs). Congrats to whole team of Costas and Yatrik !! www.cell.com/molecular-ce...
BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
Chen et al. used a reporter of endoplasmic reticulum-mitochondria contact sites (ERMCSs) to identify clinically relevant inducers of ERMCSs. They identified that fedratinib induces ERMCSs via inhibiti...
cell.com
I think we need to start calling “basic science” -> “foundational science”. There’s probably a few times it doesn’t fit, but far less confusing in meaning to a broad audience.
A new Neuro-Oncology study YBX1&YBX3 as Novel Targets to Potentiate Immune Checkpoint Blockade Response in Gliomas has been published. Crismita Dmello, PhD, is the senior author of this study, and Heba Ali, PhD, a postdoc from the Dmello Lab. academic.oup.com/neuro-oncolo...
YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas
AbstractBackground. Glioblastoma (GBM) exhibits profound resistance to CD8⁺ T cell-mediated killing, yet the tumor-intrinsic mechanisms driving this immune
academic.oup.com
JCI Insight - Palmitate impairs autophagic degradation via oxidative stress/perilysosomal Ca2+ overload/mTORC1 activation pathway in pancreatic β cells insight.jci.org/articles/vie...
JCI Insight - Palmitate impairs autophagic degradation via oxidative stress/perilysosomal Ca2+ overload/mTORC1 activation pathway in pancreatic β cells
insight.jci.org
Reposted: Cellular bicarbonate is historically known to scientists as a pH regulator or a metabolic bi-product. Our study represents the first indication that bicarbonate, similar to glutamine or aspartate, can have anabolic properties in case of cancer cell growth. www.cell.com/molecular-ce...
The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
Ali et al. showed that bicarbonate (HCO3−) is a limiting substrate for nucleotide synthesis in proliferating cells. In response to growth factor stimuli, the mTORC1-S6K-eIF4B axis promotes an increase...
cell.com
A really cool study: >> Glyceraldehyde-3-phosphate dehydrogenase homologs as bifunctional gatekeepers of metabolic segregation in Pseudomonas putida | PNAS www.pnas.org/doi/10.1073/...
Glyceraldehyde-3-phosphate dehydrogenase homologs as bifunctional gatekeepers of metabolic segregation in Pseudomonas putida | PNAS
Metabolically versatile Pseudomonas species can assimilate various glycolytic and gluconeogenic substrates. Simultaneous assimilation is known to s...
pnas.org
📢ATTENTION BSKY COMMUNITY - We are expanding!! If you are interested in studying metabolic drivers of cancer progression and therapy resistance using bioengineered models consider joining our group at the Moffitt! Pl. repost, tks moffitt-cancer-center-careers.hctsportals.com/jobs/2115134...
Postdoctoral Fellow – Focus on Metabolic Regulators of Cancer Epigenetics in Tampa, FL - Moffitt Cancer Center CareersPostdoctoral Fellow – Focus on Metabolic Regulators of Cancer Epigenetics in Tampa...
Working at Moffitt Cancer Center is both a career and a mission. All employees are dedicated to patient care, research and education to advance our fight against this disease.
moffitt-cancer-center-careers.hctsportals.com
This beautiful collaborative article has shown that PLK1, via regulation of serine metabolism, promotes sphingolipid biosynthesis in prostate cancer models. www.biorxiv.org/content/10.1...
This beautiful collaborative article has shown that PLK1, via regulation of serine metabolism, promotes sphingolipid biosynthesis in prostate cancer models. www.biorxiv.org/content/10.1...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT | Science www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
science.org
How Excessive Lipid Droplet Accumulation Alters Liver Function: www.sciencedirect.com/science/arti...
Calcium Signaling As a Therapeutic Target for Liver Steatosis
Hepatic steatosis, the first step in nonalcoholic fatty liver disease (NAFLD), can arise from various pathophysiological conditions. While lipid metab…
sciencedirect.com
www.sciencedirect.com/science/arti...
Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells
Ca2+ entry through store-operated Ca2+ channels (SOCs) in the plasma membrane (PM) of hepatocytes plays a central role in the hormonal regulation of l…
sciencedirect.com
www.sciencedirect.com/science/arti...
Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths in men, and the sixth in women. Non-alcoholic fatty liver disease …
sciencedirect.com
This small study has been kind of seminal and probably, a landmark study. Low intracellular calcium generates more lipid droplets in cytoplasm :-(. Lots of high-profile papers came out from different lab based on this discovery. portlandpress.com/biochemj/art...
Steatosis inhibits liver cell store-operated Ca2+ entry and reduces ER Ca2+ through a protein kinase C-dependent mechanism
Ca2+ entry through SOCs (store-operated Ca2+ channels; SOCE) is substantially inhibited in steatotic liver cells through a mechanism involving protein kinase C (PKC). Inhibition of Ca2+ entry enhances...
portlandpress.com
JCI - RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression www.jci.org/articles/vie...
JCI - RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression
jci.org
About twenty calcium signaling proteins were identified, including those involved in regulating calcium concentrations in the cytoplasm, endoplasmic reticulum and mitochondria. www.mdpi.com/2072-6694/12...
mdpi.com
