Professor Mary J O'Connell

@evol-molly.bsky.social

Evolutionary Biologist, Mammals, Phylogenies, Comparative Genomics, Art and Running

Our new genome annotation method relies almost entirely on transcriptome and alignment evidence, and as a result outperforms pretty much all other de novo pipelines. Check out the just-published paper led by Aleksey Zimin: rdcu.be/frSOg

Efficient evidence-based genome annotation with EviAnn

Nature Methods - EviAnn surpasses existing genome annotation methods by leveraging gene expression and protein sequence homology evidence to achieve higher accuracy and efficiency.

rdcu.be

#SMBE2026 — A wake‑up call Moisés Expósito‑Alonso showed the hard truth: genetic diversity is collapsing, and global policy is still treating it as optional. Species have already lost >10% of their genetic variation — the very engine of adaptation and survival.

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Congratulations to Eilidh Ward (first author and PhD student co-supervised by co-authors Julie Aspden, David Westhead and yours truly) on this lovely contribution - a method to visually inspect reads from novel open reading frames: doi.org/10.1093/bioa...

InspectorORF: a tool for visualising Ribo-Seq and additional genomic or transcriptomic data

AbstractMotivation. The advent of ribosome profiling (an adaptation of RNA sequencing) to determine the translatome, has led to a huge improvement in our u

doi.org

A new study by Philip Leverhulme Prize Winner Harrison Steel, @gabriel-abrahams.bsky.social and others has proved for the first time that it is possible to deliberately engineer quantum mechanical processes occurring inside a protein, and use these to create new sensing technologies.

Gabriel Abrahams@gabriel-abrahams.bsky.social · 7mo ago

Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published! Huge thank you to the many many people involved in making this happen. 🧪 www.nature.com/articles/s41...