Franz Baumdicker

@fbaumdicker.bsky.social

Mathematical and Computational Population Genetics Microbial Evolution | Machine Learning in PopGen | CRISPR-Cas | Pangenomes | HGT 🦠 ➔ 🧬 ➔ 💻 ➔ 🤔 www.baumdickergroup.de

Popgen folks, Jiseon, Nate, and Andy, along with Yuxin Ning and Franz Baumdicker, just released a really cool new method for simulation based inference (think ABC) using normalizing flows. It seems to work really well! full joint posteriors ftw! www.biorxiv.org/content/10.6...

Neural posterior estimation for population genetics

Simulation-based inference methods are increasingly being used in population genetics due to their flexibility and ability to be applied in settings where likelihood-based methods are intractable. Per...

biorxiv.org

Work from my amazing undergrad @leyan-wang.bsky.social is just preprinted! TL;DR: If you worry that ARG methods might fail on unphased data due to phasing errors, you may not need to. Check it out & consider reposting to support a great young scientist!

Leyan Wang@leyan-wang.bsky.social · 8mo ago

We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1.... This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen. 1/7

After years of working on SBI methods and the sbi toolbox, we finally wrote the practical guide we wished had existed when we started. Grateful to have collaborated with researchers across many institutions to consolidate what we've learned about making these methods work in practice!

Machine Learning in Science@mackelab.bsky.social · 9mo ago

Simulation-based inference (SBI) has transformed parameter inference across a wide range of domains. To help practitioners get started and make the most of these methods, we joined forces with researchers from many institutions and wrote a practical guide to SBI. 📄 Paper: arxiv.org/abs/2508.12939

During the COVID-19 pandemic, the millions of viral genomes coming in overwhelmed traditional methods for data analysis. Find out how SPRTA, a new tool, provides a fast, scalable way to measure confidence of phylogenetic trees, helping scientists track outbreaks. www.ebi.ac.uk/about/news/t...

SPRTA: a smarter way to measure evolution uncertainty

A new method from EMBL-EBI and collaborators offers fast, easy-to-interpret confidence scores for phylogenetic trees for pandemic preparedness.

ebi.ac.uk

Many are painfully aware that the environment within which we function -- as scientists -- needs fixing. We've come up with a proposal for academic renewal. It's not perfect, but its a start. Input, comments, suggestions are welcome. Making a difference matters 👇 doi.org/10.5281/zeno...

Pursuit of Knowledge: A Charter for Academic Renewal

This paper identifies systemic problems in how academic research is structured, evaluated, and supported. It argues for a realignment of incentives and institutional cultures to restore trust, enable ...

doi.org

stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...

Accessible, realistic genome simulation with selection using stdpopsim

Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realistic selection along heterogeneous genomes in complex de...

doi.org

In unserer neuen "Thesencheck" Episode diskutiert Politikwissenschaftlerin Dr. Melanie Nagel 11 populäre Thesen zur Klimapolitik.💦🌞🌬️💻 youtu.be/xcjqTgDsfC0 Damit ist sie die 5. Tübinger Forscherin, die im "Thesencheck" in der Öffentlichkeit herumwabernde Aussagen mit ihrer Expertise betrachtet.🔍👩‍🔬

Thesencheck - Über diese 11 Behauptungen zur Klimapolitik lässt sich streiten

YouTube video by Eberhard Karls Universität Tübingen

youtu.be