I am trilled to share my latest publication where we contribute to the knowledge of how ATR kinase, a DNA damage response factor, modulates DNA replication timing during stress in Leishmania major. Huge thanks to @rmc9z.bsky.social, @LuizTosi and the collaborators for the support and guidance!

ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major

Author summary A series of protein kinases act at the pinnacle of eukaryotic cells’ DNA damage response, organising and guiding repair. One such kinase is ATR, which recognises single-stranded DNA for...

dx.plos.org

Pleased 2 share our new article: single-molecule replication mapping in Leishmania using DNAscent. We show widespread stochastic origin firing and insights into genome variability. www.cell.com/cell-reports...

Aargh, proper link to pre-print (hopefully!) doi.org/10.1101/2025...

ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major.

All cells possess mechanisms to maintain and replicate their genomes, whose integrity and transmission are constantly challenged by DNA damage and replication impediments. In eukaryotes, the protein k...

doi.org

Richard McCulloch@rmc9z.bsky.social · 2y ago

Pleased to share new work led by Gabriel da Silva @uofgsii.bsky.social describing how the DNA repair kinase ATR modulates the unusual chromosome size-dependent pattern of DNA replication timing in Leishmania @blackjen1.bsky.social @jezieldamasceno.bsky.social and Luiz Tosi shorturl.at/RVKeX