David L. Stern

@gallseeker.bsky.social

Biologist A little obsessed by aphid galls Run a little lab @stowersinstitute.bsky.social Provide unsolicited advice to improve your science (or any) talk at howtogiveatalk.com

Some nymphs of Pemphigus spyrothecae defend their colony by attacking intruders entering the pseudo-galls on poplar in which they live. One of the few European aphids with something resembling a caste system. Here, a male Lysiphlebus fabarum is being wrestled by one of these "soldiers". [4× speed]

What can bacteria, aphids, and planarians teach us about athletic performance? 🦠 Quite a lot. As the world's best soccer players arrive in #KansasCity for the #WorldCup, explore three feats that nature takes to another level. ⚽🔬 Learn more: bit.ly/4uUFgLu

Three athletic feats that other creatures can do — but soccer players…

Kansas City is one of the host cities for the 2026 FIFA World Cup. We're highlighting a few research organisms whose natural abilities would amaze even…

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Minibwa is a hybrid of bwa-mem and minimap2 and the successor of bwa-mem for short-read mapping. ~4X/2.5X as fast as bwa-mem/bwa-mem2 for WGS reads at comparable accuracy. Native support of directional bisulfite-seq. Applicable to long reads. Preprint at arxiv.org/abs/2606.15357

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The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

New Preprint! When one enhancer allele changes another's regulatory output, is that bad? We found it could be a feature — interallelic cis-regulatory dominance buffers outputs AND enables evolutionary innovation. Two for one! Led by @ottilie.bsky.social from @embl.org doi: doi.org/10.64898/202...

Interallelic cis-regulatory dominance promotes robustness and evolutionary innovation

Dominance is a central principle of genetics, yet the mechanistic basis and the evolutionary consequences of dominance arising from cis-regulatory variation remain poorly understood. We examined the evolutionary trajectories of a pleiotropic developmental enhancer in Drosophila . A genotype–phenotype map between D. melanogaster and D. simulans enhancer sequences reveals extensive epistasis, and many homozygous evolutionary paths reduce transcriptional output. In heterozygotes, however, regulatory dominance masks variants that reduce gene expression, potentially relaxing evolutionary constraints. Using allele-specific reporters and imaging, we show that this dominance arises from interallelic interactions (also known as transvection) reinforced by transcriptional hubs. Importantly, this enhancer dominance is cell-type specific, raising the possibility that it conceals deleterious effects in essential tissues while revealing novel, ectopic activity in others. Interallelic regulatory hubs may therefore expand the range of mutational paths available to diploid genomes while preserving essential transcriptional output. ### Competing Interest Statement The authors have declared no competing interest.

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Remember her name: Aliya Rahman Her testimony is everything and it deserves to be heard, by everyone. Decide for yourself. It’s powerful. It’s gut-wrenching. And no one should have to survive what she did. ICE MUST GO‼️

The invasive soybean pest Helicoverpa armigera has acquired resistance to Bt toxins from native H. zea in Brazil. We showing this in a time series of genome data from nearly 1000 individuals over 10 years, plus a lab strain experiment that verified the function

Watch the video. Classroom learning has approximately nothing to do with being a scientist. I fondly recall John sitting in the front row of seminars, shielding his eyes from the Powerpoint garbage so that he could listen intently to the spoken words. A true inspiration.

University of Cambridge@cam.ac.uk · 10mo ago

It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r