This seems super important for in vivo experiments #Norepinephrine and #dopamine #sensor crosstalk depends on local innervation density doi.org/10.1038/s415...

Norepinephrine and dopamine sensor crosstalk depends on local innervation density - Nature Neuroscience

This study shows that GPCR-based norepinephrine and dopamine sensors display crosstalk in several brain areas. Relative innervation densities determine the extent of crosstalk, and loss-of-function co...

doi.org

Starting in Spring or Summer 2027 K99/R00 (under its new activity code KT1/R00) will only be available to US citizens, permanent residents, and non-citizen nationals. I am hearing this from many program officers, but NIH has yet to make an official statement to my knowledge.

A conserved population of genetically defined striatal neurons gates opioid reward https://www.biorxiv.org/content/10.64898/2026.07.28.741269v1

Replay of procedural memory is independent of the hippocampus 👀👀 www.nature.com/articles/s41...

Replay of procedural memory is independent of the hippocampus - Nature Neuroscience

Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error out...

nature.com

🚨Postdoc position available in computational/theoretical neuroscience at NIMH! The intramural NIH research community is great (amazing collaborators, no worrying about grants, lots of opportunities for professional development). Please repost! www.training.nih.gov/jobs/pd-0931...

The 2026 volume of the Annual Review of Neuroscience is now online 🧠 The most read article is "Planning in the Brain: It's Not What You Think It Is" by @marcelomattar.bsky.social and @nathanieldaw.bsky.social

Just how goal-directed are hippocampal theta sweeps, anyway? Great News & Views from @adredish.bsky.social Lab on recent theta goal papers: www.nature.com/articles/s41... #neuroskyence

Just how goal-directed are hippocampal theta sweeps, anyway? - Nature Neuroscience

Planning is a cognitive process that is thought to be grounded in hippocampal sequences, but recent studies have suggested that a simpler mechanism, fundamentally incompatible with those planning hypo...

nature.com

This amount would fund the US National Science Foundation for a decade. 🧪

Pentagon seeks $80 billion from Congress for Iran war

The Pentagon has told lawmakers it needs roughly $80 billion, mostly to cover the cost of the war in Iran.

apnews.com

Computational models are a key part of science but discovering new ones is hard! DataDIVER discovers concise models from data, which surface new mechanistic ideas and clear predictions for future experiments From Google Deepmind Neuroscience Lab + collaborators www.biorxiv.org/content/10.6...

Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion https://www.biorxiv.org/content/10.64898/2026.05.25.727738v1

Excellent summary of how Vought’s proposed rule will destroy science. Please be ready to comment tomorrow, call Congress, tell your friends. If you’ve been waiting for the right moment to speak up, that moment is now.

elizabethginexi.bsky.social@elizabethginexi.bsky.social · 2mo ago

Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule. Russell Vought is going destroy American Science. elizabethginexi.substack.com/p/summary-of...

TIL the MED-PC sample-without-replacement function (RANDD) generates sequential dependencies. This problem is absent in MED-PC V. www.researchgate.net/publication/...

(PDF) The misbehavior of the RANDD function in Med-PC IV

PDF | The RANDD function in Med-PC® IV is supposed to randomly select a value from a list, without replacement. By happenstance, we detected sequential... | Find, read and cite all the research you ne...

researchgate.net

I always told myself that if I could remain in research with better pay, even if not a PI, I would be thrilled. I’m therefore excited to join the Unit on Neural Computations in Learning (PI: Angela Langdon) at NIMH, where I’ll start as Research Fellow.

Could agentic AI topple grant-funding systems? Man, I hope so... the system has been broken for a while, hopefully this will force a thorough rethink. www.nature.com/articles/d41... 🧪

Could agentic AI topple grant-funding systems?

Funders must take action before an increase in submission of high-quality proposals written using AI models makes it impossible to sort the wheat from the chaff.

nature.com

Prediction without understanding sustained astronomy through a thousand years of epicycles, writes @tonyzador.bsky.social. AI is now offering neuroscience the same deal. #neuroskyence www.thetransmitter.org/machine-lear...

Can AI do neuroscience without understanding?

Prediction without understanding sustained astronomy through a thousand years of epicycles. Artificial intelligence is now offering neuroscience the same deal.

thetransmitter.org

Huge congrats to @snierwetberg.bsky.social , David (not on BSky), and @maxwellxchen.bsky.social for their paper! They developed a mouse task in which relational structure can be isolated from cue identity and reward statistics. www.biorxiv.org/content/10.6... 🧠📈🧪 #neuroskyence @uclnpp.bsky.social

Excited to share our new study on how the brain generates placebo pain relief! We developed a mouse model that recapitulates key features of human placebo analgesia, then used it to identify causal circuitry. www.sciencedirect.com/science/arti... today.ucsd.edu/story/neurob... 1/n

Neurobiologists Hack Brain Circuits Tied to Placebo Pain Relief

Scientists have identified the brain circuits tied to placebo pain relief. Researchers have known that placebo effects can be a powerful treatment, yet the underlying neurological mechanisms have not ...

today.ucsd.edu

transformer-circuits.pub/2026/emotion... This got press hate because of the word "emotions" but it is cool work. "Internal motivational states" serve as a form of working memory that helps animals organize their behavior, so why not ask if similar computational primitives help LLMs to do the same?

Hey @ditzkoff.bsky.social I knew I recognized you! Sorry for the identity mishap, trying to work on my journalist vs. neuroscientist decoder.

@jhennig.bsky.social has shown that dopamine exerts a real-time effect on conditioned responding, beyond its role in learning: www.biorxiv.org/content/10.6... Another indication that dopamine is more than a learning signal! A joint effort with @naoshigeuchida.bsky.social and @mhburrell.bsky.social.

Remember this example whenever anyone tells you that you’re generally safe living in a blue city within a red state (something I was told frequently while on the faculty job market)

Andrew Hardaway@andrewhardaway.bsky.social · 5mo ago

Context: Yesterday Central Alabama Water unilaterally decided to stop adding fluoride to the water. They are claiming that this is due to not wanting to replace $4mill of aging equipment. There was no public forum to discuss this. They just did it.

Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc. The recording is up on youtube. I hope it inspires more research on this fundamental topic! www.youtube.com/watch?v=n44x...

Cosyne 2026 - Cosyne Tutorial: Comparative Analysis of Neural Population Codes

YouTube video by Cosyne Talks

youtube.com

Today in @nature.com, the @christophthaiss.bsky.social & @maayanlevy.bsky.social labs trace age-related memory loss to the gastrointestinal tract & map the complete gut-to-brain pathway driving it. Targeting this pathway can reverse cognitive aging in mice. www.nature.com/articles/s41...

Check out our latest research drop! We show BLA dopamine signaling encodes the emotional weight of sensory transitions, but not the associative strength or value of stimuli. These signals dynamically rescale when the learning context changes: "this matters most!" www.biorxiv.org/content/10.1...

Here's a quick analysis I did on data I've been collecting on psych/neuro faculty applicants. I don't have data on unsuccessful applicants, but my inference is that women mentored by women have to rely more on bringing in $ to get a faculty job than men mentored by men.

Very excited to post our paper led by @daburke.bsky.social www.nature.com/articles/s41... where we uncover a simple mathematical rule underlying how brains learn that a cue predicts a reward. 1/26

Duration between rewards controls the rate of behavioral and dopaminergic learning - Nature Neuroscience

Cue–reward learning rate scales proportionally with the time between rewards. Consequently, learning over a fixed duration is independent of the number of trials. This challenges trial-based dopamine ...

nature.com

Now published in Neuropharmacology! www.sciencedirect.com/science/arti...

Fentanyl reinforcement history has sex-specific effects on multi-step decision-making

It is commonly thought that drug addiction involves a transition to habitual control of action, where the choice to consume drugs becomes automatized …

sciencedirect.com

Eric Garr@garrface.bsky.social · 2y ago

I’m very excited to present this work, led with my co-first author Yifeng Cheng. Check it out if you’re interested in opioids, reinforcement learning, and sex differences! Thread below 👇 www.biorxiv.org/content/10.1...

Science: U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office By Jeffrey Mervis, Monica Hersher @science.org @policyhound.bsky.social @mghersher.bsky.social bit.ly/3M8yf9B

U.S. government has lost more than 10,000 STEM Ph.D.s since Trump took office

A Science analysis reveals how many were fired, retired, or quit across 14 agencies

bit.ly

Since the Namboodiri lab isn’t on Bluesky (I think?), I’d like to amplify this cool paper which I and others in the Janak lab made a small contribution to.

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 7mo ago

Memory erasure by dopamine-gated retrospective learning https://www.biorxiv.org/content/10.64898/2026.01.17.700100v1

The conference (agreement between House and Senate) appropriations bill that includes HHS and NIH was released this morning. www.appropriations.senate.gov/news/majorit... 1/5

Committee Releases Conferenced Defense, Homeland Security, Labor, Health and Human Services, Education, and Related Agencies, and Transportation, Housing and Urban Development, and Related Agencies Bi...

United States Senate Committee on Appropriations

appropriations.senate.gov