Jay Hennig

@jhennig.bsky.social

Computational neuroscientist interested in how we learn, and dad to twin boys Asst prof at Baylor College of Medicine https://www.henniglab.org/

I had a feeling recently that seems to be corroborated by chats with colleagues, so I decided to share it here. A lot of systems neuroscientists driven by algorithmic-level questions are going through what looks and feels like a research depression. 🧵 (1/n) 🧠📈 #NeuroAI

New preprint from our lab ⚡ Why do DA and BF bursting neurons carry such similar reward-prediction signals? Are they independent, driven by common input, or causally linked? We find a direct answer: DA activity rapidly and causally drives BF. www.biorxiv.org/content/10.6... 1/10

Dopamine neurons drive basal forebrain reward prediction in milliseconds

Phasic reward prediction signals in ventral tegmental area (VTA) dopamine (DA) neurons and basal forebrain (BF) noncholinergic bursting neurons are remarkably similar despite the distinct circuit…

biorxiv.org

Excited to see this work published! We find that the brain codes semantic relationships similar to contextual LLMs (like GPT2) but unlike LLMs, uses contrastive coding to prevent confusion of highly similar words. Many thanks to the reviewers and BCM neurosurgery team! www.nature.com/articles/s41...

A population code for semantics in human hippocampus - Nature Neuroscience

Franch et al. show that human hippocampal neurons encode the meanings of the words we hear through distributed, context-sensitive population activity that mirrors some features of large language model...

nature.com

Happy to have this finally out! TL;DR: The evolution of beliefs over time can be formulated as a dynamical system, and OFC neural activity appears to implement this system with its own dynamics. These emerge without explicit supervision—when animals learn to predict value in simple Pavlovian tasks

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2w ago

Dynamic belief representation and updating through learned attractor-like dynamics in the frontal cortex https://www.biorxiv.org/content/10.64898/2026.09.17.752495v1

my favourite form of grad student flex: you roll up to lab meeting with pilot data which demonstrates that the study is working exactly as expected, but you didn't tell anyone ahead of time. the lab finds out all at once, together

We also built a fast, differentiable form of DSA — ∂DSA. With this, we showed we can train RNNs online with DSA to learn novel, never-before-hypothesized solutions to computational tasks! (Stay tuned for future work on this too!) (8/)

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𝗥𝗲𝗰𝗼𝗿𝗱𝗶𝗻𝗴 𝗮𝗰𝗿𝗼𝘀𝘀 𝗯𝗿𝗮𝗶𝗻 𝗱𝗶𝘀𝗰𝗼𝘃𝗲𝗿𝘀 𝗯𝗿𝗮𝗶𝗻𝘄𝗶𝗱𝗲 𝗿𝗲𝗽𝗿𝗲𝘀𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻𝘀 Neuroscientists now recording across the brain are finding what fMRI revealed in humans. Signals are not localized but often all over the brain. (NB: non, it's not everything, everywhere) #neuroskyence www.biorxiv.org/content/10.6...

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New preprint! 🧠 How do reward, risk & information preferences relate to psychopathology? How do they vary across decisions about gains vs. losses? 1,954 people! Hundreds of economic choices each + transdiagnostic assessment of mental health symptoms online. www.biorxiv.org/content/10.6...

A dimensional link between gain-loss economic preferences and psychopathology

Human decision-makers differ in how they value and trade off reward, risk, and information when evaluating future gains and losses, and these preferences are central to well-being. However, how multi-...

biorxiv.org

This is such cool work, especially the idea that on-manifold geometry is "imposed by the circuit's intrinsic dynamics" and not just stim encoding. We think something similar happens in human hippocampus—though tbf we haven't characterized the stimulus encoding dims yet bsky.app/profile/jhen...

Eliezyer de Oliveira@eliezyer.bsky.social · 3w ago

After a long journey through review, our paper is finally out in Nature Communications. We started with a simple problem: The visual cortex is strongly modulated by movement. So how can it represent the visual world without movement interfering with everything? www.nature.com/articles/s41...