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Manx Neurobiologist

@garyrlewin.bsky.social

Manxman Scientist. Neurobiologist, Group Leader, Interests: ion channels, extreme biology, mole-rats, sensory transduction, touch, pain, social brain, flying www.mdc-berlin.de/lewin

31 Posts262 Follower101 Folgt
NYU Pain Research Center@nyupainresearch.bsky.social · 3mo ago

New research maps the proteomes of individual sensory neuron subtypes, revealing how protein-level changes drive nociceptor sensitization, opening fresh avenues for #painresearch. @garyrlewin.bsky.social @amapruns.bsky.social

Deep visual proteomics uncovers nociceptor diversity and pain targets - Nature Communications

Sensory neuron subtypes are defined by transcriptomics, but their proteomic identities remain unclear. Here, authors show distinct protein signatures of electrophysiologically defined nociceptors and…

buff.ly

Manx Neurobiologist@garyrlewin.bsky.social · 9mo ago

We were very happy to help, in a very small way, in getting this beautiful structure out. The structure is remarkably conserved considering the famous 28S ribosomal RNA split. I suspect that the split has as yet unknown biological repercussions in this remarkable animal..

Misha Kudryashev@mishakudryashev.bsky.social · 9mo ago

We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity. Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look. www.biorxiv.org/content/10.1...

Manx Neurobiologist@garyrlewin.bsky.social · 9mo ago

Check out this new paper from Stefan Lechner's lab showing with minflux nanoscopy how PIEZO1 channels cluster and invagininate the membrane. Glad we could make a small contribution to this nice story! www.science.org/doi/full/10....

Cluster nanoarchitecture and structural diversity of PIEZO1 at rest and during activation in intact cells

MINFLUX nanoscopy reveals subcellular distribution and conformational diversity of PIEZO1 channels in intact cells.

science.org

Manx Neurobiologist@garyrlewin.bsky.social · 10mo ago

Sam has now started her new group at the Helmholtz Center for Infection Research Diseases. Congratulations! I wish her the very best for her independent career. The time Sam spent with us was hugely successful in many respects and we will all be sad to see her go..

Sampurna Chakrabarti@amapruns.bsky.social · 10mo ago

Delighted to be starting a new research group at @helmholtzhzi.bsky.social ! Happy to chat about working together! #pain #infection #electrophysiology www.helmholtz-hzi.de/en/research/...

Manx Neurobiologist@garyrlewin.bsky.social · last yr.

Widely accepted findings should be validated. For example, mechanically-activated currents (MA-currents) in sensory neurons depend on PIEZO2..right?. Here we show that PIEZO2 is NOT associated with a huge loss of MA-currents in sensory neurons. #ion channels #sensory www.biorxiv.org/content/10.1...

Mechanically-gated currents in mouse sensory neurons lacking PIEZO2

Touch sensation starts with the opening of mechanically-gated activated ion channels at neuroglial endings of mechanoreceptors in the skin. The function of around half of low threshold mechanoreceptor...

biorxiv.org

Manx Neurobiologist@garyrlewin.bsky.social · last yr.

physoc.onlinelibrary.wiley.com/doi/full/10.... Our latest paper is now published, open access of course. Check it out! Mechanotransduction and regeneration! More to come soon..

The mechanotransduction protein STOML3 is required for proprioceptor plasticity following peripheral nerve regeneration

Nerve regeneration is associated with the plasticity of sensory neurons such that even muscle afferents directed to the skin form mechanosensitive receptive fields appropriate for the new target. STO...

physoc.onlinelibrary.wiley.com