I can confirm the NIH is still working well enough to score my R01 terribly 😂🤪

Congratulations to newly PhD'ed @pieceofkate.bsky.social Dr. McCluskey!! She gave a fantastic thesis seminar to cap it off 👏🎓🐸✨

Appreciate this generous write up on our recent preprint! www.thetransmitter.org/spectrum/hai...

Many autism-linked proteins influence hair-like cilia on human brain cells

The finding may help explain autism’s association with multiple co-occurring conditions that involve cilia defects.

thetransmitter.org

My New Year’s resolution is to be kind… of a bitch.

Check out our new preprint led by @elinakosty.bsky.social identifying convergence of autism proteins at the cilium (including chromatin regulators and synaptic proteins)! Makes us realize the deep similarity between neuronal synapses and cilia. Power of 🐸 for discovery

ElinaK@elinakosty.bsky.social · 2y ago

Check out our new ✨preprint ✨📝 describing extraordinary convergence of autism proteins at the cilium, a 🧵 www.biorxiv.org/content/10.1... (1/ )

It's #FluorescenceFriday again! Some more #Xenopus... This time a #gastruloid formed by treating an explant of blastula presumptive ectoderm cells with Activin. Nuclei labelled with H2B-mCherry with colour indicating size.

Another preprint from the lab and a collaboration with Miriam Schmidts and her lab from Uniklinik_Fr pediatrics. This work was carried out mostly by fantastic MD MOTIVATE student Henrike Berns. Funded by @dfgpublic.bsky.social @cibss.bsky.social and SFB1453_NephGen. www.biorxiv.org/content/10.1...

A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects

Wnt signaling plays important roles during vertebrate development, including left-right axis specification as well as heart and kidney organogenesis. We identified a homozygous human WNT11 variant in ...

biorxiv.org

Hello science peeps A quick introduction to Miller lab shenanigans 🐸😄 @umichlawlib.bsky.social We are very demure, very mindful labmates 🧪 🥼 #Scienceisfun

Check out our new ✨preprint✨ led by James Schmidt! Here we identified a new role for the gene KANSL1 in ciliary biology using Xenopus, with validations in patients with associated Koolen-de Vries Syndrome, which is characterized by hypersociability. www.biorxiv.org/content/10.1...

okay has anybody made one of these for #cilia peeps yet?? go.bsky.app/ELfYqxw please find & add more names below...

Xenopus researchers (and only Xenopus researchers!) Open now! Xenbase.org wants to hear from you about how you use Xenbase and what they can do to make Xenbase even better. Just click forms.gle/5WFANQTKA6TuSyg67 to take the survey! #science #biology #devbio #xenopus #frogs @xenbase.bsky.social

Let's kick things off with live imaging of Xenopus deep layer blastocoel roof cells imaged using Airyscan 2.

Hello world! We’re here to spread the love of our favorite model organism Xenopus. Give us a follow for your daily moment of Xen(opus)!

New preprint from the lab 🙌 @biorxiv. We found new foxi1 functions in multipotent mucociliary progenitors in #xenopus. 🐸 www.biorxiv.org/content/10.1... Congrats to 3 first authors Sarah Bowden, Magdalena Brislinger-Engelhardt, Mona Hansen & team! Fu dwd by CIBSS SFB1453_NephGen dfg

Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms

Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β-ISCs regulate pH- and ion-homeostasis in epithelia. Gain and loss of FOX...

biorxiv.org