Leo Yuan
@greatysp.bsky.social
Senior Scientist @Altos Labs | Formerly Stem Cell / Cancer Bio at @thefuchslab.bsky.social @rockefelleruniv.bsky.social @hhmi.bsky.social & Pulmonary Bio at @ucsfmedicine.bsky.social | Co-founder @Aer Therapeutics | Theatre & Art Lover | Adventurer
The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com www.nature.com/articles/s41...
Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature
Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...
nature.com
New paper alert! We report in @cp-cellmetabolism.bsky.social how serine regulates stem cell fate in physiology and upon wounding. Good work, Jesse and collabs! www.cell.com/cell-metabol...
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury
Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and accelerate...
cell.com
Fantastic talk by @thefuchslab.bsky.social on the highly anticipated work on inflammatory memory with aging… congratulations to @chris-cowley14.bsky.social @rajsajjath.bsky.social et al
Congratulations to @jorgealmagro.bsky.social and @thefuchslab.bsky.social as well!! 🎊🎉🥳🥳 @rockefelleruniv.bsky.social @hhmi.bsky.social
🥳 Our 4th most downloaded article in 2024: Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues https://bit.ly/42Cvr... @rockefelleruniv.bsky.social @hhmi.bsky.social @natureportfolio.bsky.social #NRCtop10of2024
Our first 2025 paper! We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer. Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏 www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
nature.com
Congratulations to @jorgealmagro.bsky.social @thefuchslab.bsky.social @rockefelleruniv.bsky.social @hhmi.bsky.social for this landmark review! And happy snake year! 🐍🧧
Very happy to see our review out in @natrevmcb.bsky.social! Here we discuss how stem cells exert forces to sculpt tissues in development and homeostasis, and how stem cell mechanics go awry upon malignant transformation. Read it here 👇 www.nature.com/articles/s41...
Kicking off 2025 Paper of the Week with @kevinng.bsky.social & @fesubtil.bsky.social. Today we discussed our friend @martinaparigi.bsky.social et al. recent paper in @nature.com. How do epithelia unlink necessary drivers of regeneration from malignant transformation? www.nature.com/articles/s41...