Elaine Fuchs Lab
@thefuchslab.bsky.social
Mammalian cell biology and development lab at @rockefelleruniv.bsky.social & @hhmi.bsky.social ▪️Epithelia, stem cells, inflammation, cancer and more!
Our paper is out in @science.org describing how epithelial cells retain long-term inflammatory memory www.science.org/doi/10.1126/...
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory
Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understood....
science.org
Very cool study uncovering how stem cells pass on imprints to progeny in vivo from. @thefuchslab.bsky.social @danapeer.bsky.social drawing from beautiful work done by @grothlab.bsky.social on epigenetic inheritance and the mechanisms of information transfer through cell division.
Waggoner Lab@labwaggoner.bsky.social · 4mo agoSpecific DNA sequence features encode the persistence of epigenetic memory of inflammation @science.org thefuchslab.bsky.social @rockefeller.edu @mskcancercenter.bsky.social www.science.org/doi/10.1126/...
In this piece from @natcancer.nature.com, Rockefeller's Elaine Fuchs (@thefuchslab.bsky.social)—renowned for her research in skin biology, stem cells and associated disorders, including cancers and inflammation—recounts her scientific career.
A 180 degree turn en route to crafting a scientific career that never goes stale - Nature Cancer
Elaine Fuchs is renowned for her research in skin biology, stem cells and associated disorders, including cancers and inflammation, and has published over 380 articles. She received her PhD in biochem...
nature.com
New paper alert! We report in @cp-cellmetabolism.bsky.social how serine regulates stem cell fate in physiology and upon wounding. Good work, Jesse and collabs! www.cell.com/cell-metabol...
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury
Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and accelerate...
cell.com
Fantastic talk by @thefuchslab.bsky.social on the highly anticipated work on inflammatory memory with aging… congratulations to @chris-cowley14.bsky.social @rajsajjath.bsky.social et al
Rockefeller's @thefuchslab.bsky.social weighs in on new research showing that human wounds take more than twice as long to heal as wounds of any of the other mammals in the @nytimes.com:
Humans’ Wounds Heal Much More Slowly Than Other Mammals’
We naked apes need Band-Aids, but shedding the fur that speeds healing in other mammals may have helped us evolve other abilities.
nytimes.com
Very timely and insightful review from @thefuchslab.bsky.social on epithelial stem mechanobiology and the role of mechanics in controling epithelial tissue (morpho)dynamics in development and cancer! A must read for anyone in the field 👇!
Elaine Fuchs Lab@thefuchslab.bsky.social · 2y agoOur first 2025 paper! We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer. Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏 www.nature.com/articles/s41...
And the #AACRFellows have elected Elaine V. Fuchs, PhD, FAACR, of @RockefellerUniv.bsky.social as the next President of the AACR Academy. www.aacr.org/professional...
Great news! @greatysp.bsky.social @jorgealmagro.bsky.social
Nature Reviews Cancer@natrevcancer.nature.com · last yr.🥳 Our 4th most downloaded article in 2024: Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues https://bit.ly/42Cvr... @rockefelleruniv.bsky.social @hhmi.bsky.social @natureportfolio.bsky.social #NRCtop10of2024
Congratulations to @jorgealmagro.bsky.social and @thefuchslab.bsky.social as well!! 🎊🎉🥳🥳 @rockefelleruniv.bsky.social @hhmi.bsky.social
Nature Reviews Cancer@natrevcancer.nature.com · last yr.🥳 Our 4th most downloaded article in 2024: Beyond genetics: driving cancer with the tumour microenvironment behind the wheel by @thefuchslab.bsky.social & colleagues https://bit.ly/42Cvr... @rockefelleruniv.bsky.social @hhmi.bsky.social @natureportfolio.bsky.social #NRCtop10of2024
New #Review! 🥳 @jorgealmagro.bsky.social, @thefuchslab.bsky.social et al. discuss the role of stem cell mechanics during developmental processes and what happens when the mechanics of the stem cell niche are disrupted in cancer. 👉 go.nature.com/3EsJzJx #StemCells #Mechanobiology #Cancer
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
go.nature.com
Very happy to see our review out in @natrevmcb.bsky.social! Here we discuss how stem cells exert forces to sculpt tissues in development and homeostasis, and how stem cell mechanics go awry upon malignant transformation. Read it here 👇 www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
nature.com
Our first 2025 paper! We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer. Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏 www.nature.com/articles/s41...
Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology
Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...
nature.com
Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!
Thrilled to announce that two Rockefeller scientists have been named @hhmi.bsky.social Hanna Gray Fellows! Congratulations to @paigearnold.bsky.social of the Marraffini lab and Jim Castellanos of @thefuchslab.bsky.social and Weill Cornell Medicine on their awards!
HHMI Names the 2024 Hanna Gray Fellows | HHMI
The cohort includes early career scientists working in research areas ranging from treatment-resistant cancers to how animals evolved to live on land. The HHMI Hanna H. Gray Fellows Program provides e...
hhmi.org
🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉 @natrevmcb.bsky.social ! Here is the SharedIt link for free access: rdcu.be/d5ppE
Circadian clock communication during homeostasis and ageing
Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...
rdcu.be
2024 was a year of exciting discoveries and scientific discussions! A thread 🪡 of this years’ publications from our lab 👇🏼
Getting our Bsky started with our yearly Holiday picture! 🌟 Happy Holidays from the Fuchs lab!
