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Torben Heick Jensen

@heick.bsky.social

RNA decay, RNA sorting, gene expression

10 Posts802 Follower1795 Folgt
Ulrich Hohmann@hohmannulrich.bsky.social · last mo.

Super cool to see the result of our collaborative work with @heick.bsky.social 's lab finally out! Shaped through many discussions with @abugai.bsky.social, @lorenzoana.bsky.social & @max2max.bsky.social, @juliusbrennecke.bsky.social & Clemens, trying to decipher LENG8's secrets!

Plaschka lab@plaschkalab.bsky.social · 2mo ago

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

Ulrich Hohmann@hohmannulrich.bsky.social · 11mo ago

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Molecular basis of polyadenylated RNA fate determination in the nucleus

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

biorxiv.org

Julius Brennecke@juliusbrennecke.bsky.social · 11mo ago

Dream collaboration with the groups of Torben Heick Jensen (@heick.bsky.social; @au.dk) and Clemens Plaschka (@impvienna.bsky.social). Building in part on the incredible work from Ulrich Hohmann on human mRNA export. www.biorxiv.org/content/10.1...

A molecular switch orchestrates the nuclear export of human messenger RNA

The nuclear export of messenger RNA (mRNA) is a key step in eukaryotic gene expression ([Köhler and Hurt, 2007][1]). Despite recent insights into the packaging of newly transcribed mRNAs into ribonucl...

biorxiv.org

Torben Heick Jensen@heick.bsky.social · last yr.

Final call for postdoc positions in Aarhus, Denmark. Sorting of gene expression and beyond. Please get in touch for further information or apply using this link: mbg.au.dk/en/news-and-...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

Torben Heick Jensen@heick.bsky.social · last yr.

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

Apoorva Baluapuri@baluapuri.bsky.social · last yr.

Thrilled to see my work with @adelmanlab.bsky.social on INT/dsRNA highlighted by @willgarland.bsky.social and @heick.bsky.social ! Thanks for beautifully capturing how nuclear RNA guardians prevent cellular chaos. The ripple effects of transcriptional dysregulation are indeed profound! #RNABiology

William Garland@willgarland.bsky.social · last yr.

We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social. Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.

Peter Andersen@germline.bsky.social · last yr.

📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University

mbg.au.dk

Josh Mendell@mendell-lab.bsky.social · 2y ago

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation! www.science.org/doi/10.1126/...

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

science.org