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@guyrutter1.bsky.social

13 Posts95 Follower47 Folgt
@guyrutter1.bsky.social · last yr.

Our new report with #YaChiHuang and #MarjanRupnik deploys high-speed multicellular imaging in pancreatic slices to reveal roles for both cell intrinsic and paracrine mechanisms in glucose inhibition of alpha cells - and the effects are sex-specific. #CRCHUM. www.biorxiv.org/content/10.1...

Pancreatic α-cells are functionally heterogeneous and sex-dependently regulated by neighboring endocrine cells

Glucose and paracrine regulation on α-cells, particularly with respect to sex differences, remains unclear. Hence, we imaged islets of GluCre:GCaMP6f^fl/fl mice in pancreatic slices, additionally loaded with a red Ca2+ dye, to precisely interrogate Ca2+ dynamics in α-cells and the adjacent β- and δ-cells. During a glucose ramp (1.8-10.8mM), α-cell Ca2+ oscillations were heterogeneous, antiphasic to β-cells, and inversely correlated with δ-cells. Selective inhibition of insulin receptor (InsR) and somatostatin receptor subtypes-2 and 3 (SSTR2/3) shifted the majority of α-cells to hyperactivity, delayed the decline of α-cell activity and onset of synchronized β-cell Ca2+ oscillations during the ramp. While female α-cells exhibited greater sensitivity to SSTR2/3 inhibition, male α-cells were more responsive to InsR blockade. Under complete SSTR2/3 and InsR antagonism, α-cells exhibited elevated Ca2+ oscillations but remained glucose-dependent. We conclude that intra-islet coordination fine-tunes α-cell glucose responses, with sex-specific paracrine signaling potentially shaping glucagon profiles in metabolic disease. ### Competing Interest Statement The authors have declared no competing interest.

biorxiv.org

@guyrutter1.bsky.social · last yr.

Delighted to be on the list of Fellows elected to the Academy of Medical Sciences today. Looking forward to playing a role in the Academy’s activities and in forging and reinforcing international partnerships.

Academy of Medical Sciences@acmedsci.bsky.social · last yr.

Congratulations to the 54 exceptional scientists who have been elected to the Academy Fellowship today in recognition of their remarkable contributions to biomedical and health sciences 🎉 👉 Discover more: ow.ly/Cf7K50VWSRi #HealthResearch #HealthInnovation #AcademyFellows

Academy President Prof Andrew Morris next to a quote that reads: "It is a privilege to welcome these 54 exceptional scientists to our Fellowship. Each new Fellow brings unique expertise and perspective to addressing the most significant health challenges facing society."
Daniel Drucker@danieljdrucker.bsky.social · last yr.

"Just some of the triumphs that have come from our robust biomedical research enterprise. NIDDK, as a reflection of work done across the entire NIH, is a prime example of government monies well spent" The 75th anniversary of #NIDDK #NIH diabetesjournals.org/care/article...

NIDDK at 75 Years of Age: Great Triumphs but Concerns for Its Longevity

Steven E. Kahn, Cheryl A.M. Anderson, John B. Buse, Elizabeth Selvin, David A. D’Alessio; NIDDK at 75 Years of Age: Great Triumphs but Concerns for Its Lon

diabetesjournals.org

Centre de recherche du CHUM@crchum.bsky.social · 2y ago

Pour souligner la Journée internationale des femmes et des filles de science, notre comité ÉDI vous invite à découvrir les parcours uniques de quatre femmes. Pour vous inscrire c’est par ici ➡️ bit.ly/4jgbnka Le grand public est invité à participer en ligne par le biais de la plateforme Zoom.

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@guyrutter1.bsky.social · 2y ago

First post! Our new report with #ShivanMisra and #DieterEgli on a recessive HNF1A variant as modelled in iPS beta cells. From force of nature #InesCherkaoui. medrxiv.org/cgi/content/...

Investigating the pathogenicity of the recessive HNF1A p.A251T variant in monogenic diabetes using iPSC-derived beta-like cells

Monogenic diabetes, formerly called Maturity-Onset Diabetes of the Young (MODY), involves single-gene mutations, typically with dominant inheritance, and has been associated with variants in 14 genes....

medrxiv.org